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CNCR Mouse Behavior Course In vivo phenotyping of mutant rodents: integrating neural activity, heart rate and behavior Course Organizers Tommy Pattij, Ph.D., Vrije Universiteit Medical Center ([email protected]) Antonius B. Mulder, Ph.D., Vrije Universiteit Medical Center ([email protected]) Matthijs Verhage, Ph.D., Vrije Universiteit Amsterdam ([email protected]) Oliver Stiedl, Ph.D., Vrije Universiteit Amsterdam ([email protected]) Location Institute for Neurosciences (INW) and Center for Neurogenomics and Cognitive Research (CNCR) Faculty of Earth and Life Sciences (FALW), Vrije Universiteit Amsterdam De Boelelaan 1085, 1081 HV Amsterdam, Netherlands Date: September 10-18, 2007 Course limit: 18 participants Application deadline: August 1, 2007 Attendance fee: 250 Euro (academic rate) Course Web Site: www.cncr.nl/MBCourse.pdf Course sponsors • EU Synapse • ONWA • NIN - Netherlands Institute for Brain Research • Vrije Universiteit Amsterdam / FALW Education • CNCR CNCR Mouse Behavior Course • In vivo phenotyping of mutant rodents • Sept. 10-18, 2007 2 Objectives This course is a combined lecture and practical course on the behavioral characterization of rodents including genetically modified mice. We intend to teach principles of behavioral analysis of phenotypes useful for PhD students working in the field of (behavioral) neuroscience who are interested in an integral approach to phenotyping of rodents extending to neural and autonomic responses. More specifically, our aim is to • outline conceptual issues in behavioral neuroscience focusing on a combination of autonomic electrophysiological and neurochemical methods • outline methodological issues to be considered when designing behavior experiments; • provide hands-on experience on electrophysiological and autonomic recording techniques in combination with behavior methods. Scientific relevance of these techniques Behavior techniques are essential to analyze the phenotype of rodents including mutant mice with regard to psychopathology models. Behavioral methods need to be complemented by electrophysiological and autonomic techniques for an improved understanding of underlying mechanisms. The importance of the use of a broader method spectrum and experimental limitations will be discussed in the course. Behavior experiments provide unique information about the role of genes in sensorimotor function, perception, attention, anxiety, learning and memory, and other aspects of higher cognitive functioning. Inducible and region-specific genetic techniques permit to ask more specific questions and are becoming increasingly important. But these new techniques also impose additional constraints on behavior experiments, for example with respect to genetic background or time schedule. Thus, having profound expertise when testing the behavior of genetically modified mice is more important than ever. Course structure The detailed timetable of the course is attached below. • Morning: two 45 min lectures on conceptual and methodological issues followed by a discussion with the lecturer. • Noon: Extended joint lunch with an informal discussion with the morning lecturers of that day. An opportunity to ask detailed questions and start debates about the value of various techniques with the lecturers. • Afternoon: practical work in groups of 3 students attending practical demonstrations and performing experiments themselves. Practicals Planned themes include an exposure to various tests and techniques used under in vivo conditions in freely moving mice. Behavior tests: anxiety tests , spatial learning and operant and classical conditioning (including fear conditioning, passive avoidance learning) Autonomic measurements: introduction to heart rate measurements and data analysis Electrophysiological recordings: tetrode recordings, telemetric single unit recordings. A separate practical course timetable is in preparation Surgical techniques: ECG transmitter implantation, cannula placement for central injections in mice, electrode implantation for electrophysiological recording Course staff In addition to the course organizers, internationally renowned experts ensure a high standard of the course. The following renowned scientists have been invited and have already agreed to participate in the course: CNCR Mouse Behavior Course • In vivo phenotyping of mutant rodents • Sept. 10-18, 2007 3 Bauke Buwalda - University Groningen, Netherlands John Cryan - University Cork, Ireland Jeff Dalley - University Cambridge, United Kingdom Matthijs Feenstra - Netherlands Institute for Neuroscience, Amsterdam, Netherlands Cornelius Gross - EMBL Monterotondo, Italy Michael Hasselmo - Boston University, USA Stephan von Hörsten, University Erlangen-Nuremberg, Germany Martien Kas - University Utrecht, Netherlands Hans-Peter Lipp - University Zurich, Switzerland Sven Ove Ögren - Karolinska Institutet, Stockholm, Sweden Paul Philipps - University Washington, Seattle, USA Andrea Sgoifo - University Parma, Italy Sabine Spijker - Vrije Universiteit Amsterdam, Netherlands Berry Spruijt - University Utrecht, Netherlands In addition to the course organizers, excellent technicians will support the demonstrations and help supervising the day-to-day practical work. To whom the course is aimed and how to apply The course is intended for advanced graduate students and early postdoctoral students in molecular neurobiology, neuroscience, physiology, behavioral pharmacology and experimental psychology. A maximum of 18 participants will be selected. The selection will be based on academic excellence and evidence for genuine interest and motivation. To apply, applicants should fill in the attached application form. It should be printed out and returned together with the requested additional information and material by regular mail as fax or as an email attachement (preferably as a pdf-file) to the Course Office address provided on the form. On request a limited number of student accommodations can be provided at additional costs (Euro 250). Course fee is 250 Euro (academic rate). The bank connection will be provided to selected participants and the subject “CNCR Mouse Behavior Course 2007”after approval of participation by the organizers. CNCR Mouse Behavior Course • In vivo phenotyping of mutant rodents • Sept. 10-18, 2007 CNCR Mouse Behavior Course, Vrije Universiteit Amsterdam, The Netherlands September 10-18, 2007 Application Form - PLEASE PRINT CLEARLY Name Date of birth Address (affiliation) Telephone FAX E-mail Current position Behavior experience (Permits: e.g. art. 9) Research interests (max. 50 words) Signature 4 CNCR Mouse Behavior Course • In vivo phenotyping of mutant rodents • Sept. 10-18, 2007 Reason for application (max. 100 words) Please print and return the completed form with the following enclosures: • Curriculum vitae and list of publications • One publication illustrating the currently used methods and research interests (if available) • A letter of recommendation from the supervisor, head of laboratory, or head of department Please submit the application forms and enclosures to the following address: CNCR Mouse Behavior Course 2007 Els Borghols (email: [email protected], Tel. +31 (0)20 59 86925, Fax: +31 (0)20 59 86926) Department of Functional Genomics Institute of Neurosciences, FALW, Vrije Universiteit Amsterdam De Boelelaan 1085, 1081 HV Amsterdam The Netherlands 5