Download Curriculum Vitae

Curriculum Vitae
Name:
Address:
Born:
Married:
Children:
Nationality:
Education:
Lingeman, Hendrik
Bottelroosweide 3
3448 ZA Woerden
Tel.: 0348 481 238 / Fax.: 0348 481 028
E-mail: [email protected]
June 9, 1954 (male)
May 19, 1978 with Anne-Marie Birfelder
November 17, 1990 (Mariska Danielle)
Dutch
State University Utrecht, Subfaculty of Pharmacy
BA examination
Nov. 1975
MA examination
Apr. 1980
Final Analytical examination Nov. 1981
Start Ph.D. study
Dec. 1981
End Ph.D. study
Dec. 1985
Ph.D. examination
Mar. 1986
Present Position:
Since March 1, 1991 I am a senior staff member
(Associate Professor) of the:
Department of Analytical Chemistry
Faculty of Chemistry
Vrije Universiteit (Free University)
De Boelelaan 1083
1081 HV Amsterdam
The Netherlands
Tel.:
020 - 444 7539
Fax.:
020 - 444 7543
E-mail:
[email protected]
Former Positions:
From December 1, 1981 to December 1, 1985 I was a
Ph.D. student at the:
Department of Analytical Pharmacy
Pharmaceutical Laboratory
State University of Utrecht
Utrecht
The Netherlands
From December 1, 1985 to December 1, 1988 I was a
junior staff member (Post-Doc) of the:
Division of Analytical Chemistry
Center for Bio-Pharmaceutical Sciences
State University of Leiden
Leiden
The Netherlands
From December 1, 1988 to march 1, 1991 I was a staff
member (Assis-tant professor) of the:
Department of Analytical chemistry
Faculty of Chemistry
Vrije Universiteit
Amsterdam
The Netherlands
Research Activities at Utrecht University:
1972 (4 months): Development of a TLC method for
the determination of theophylline in plasma samples;
1978 (8 months): Development of a GC method for the
determination of nalidixic acid in plasma samples;
1980 (12 months): Stability and spectrofluorometric
research with respect to cytostatic drugs (e.g.,
mitomycin C, porfiromycin, 6-mercaptopurine);
1981 - 1985: Selective pre-column derivatization
methods for carboxylic acids (LC with fluorescence
detection and GC with nitrogen selective detection)
and LC analysis of basic compounds on non-modified
silica and aluminum in aqueous solvent mixtures
(Ph.D. Study).
Supervising Research Activities at Leiden University
Laser-induced fluorescence derivatization / detection
of peptides in biological fluids after LC separation;
Development of automated on-line (in combination
with LC) sample preparation procedures for the
determination of drugs in biological fluids;
Development of chromatographic bioanalytical
methods for cytostatic agents (mitomycin C, 5fluorouracil), endogenous peptides, interferons,
interleukins, catecholamines, isoxazolylpenicillins and
the application of these methods in pharmacological,
clinical and pharmacokinetic studies.
Supervising and Co-ordinating Research Activities at the Vrije Universiteit
-
-
-
-
-
-
-
-
Development of on-line systems combining GC
detectors with LC and SFC;
Development of post-column reaction / detection
systems based on post-column ion-pair formation and
fluorescence detection, including photochemical
reactions, for acidic compounds in biological and
environmental samples;
Development of automated on-line preconcentration
systems with LC and photodiode-array detection for
pesticides in tap, surface and waste water;
Development of automated on-line sample preparation
techniques (e.g., dialysis, immunoaffinity precolumns,
column switching, automated SPE, membraneextraction disks) for LC;
Development of diode laser-induced fluorescence
detection systems for LC and sensor devices;
Development of on-line monitoring systems for
fermentation processes based on ultrafiltration and LC;
Development of injection and detection systems in
CZE and bioseparations of collagen proteins and
protein fragments;
Development of chemiluminescence systems for the
determination of drugs in biological fluids;
Development of automated sample preparation
procedures for organic compounds in combination
with CZE;
Development of membrane-based extraction
procedures for the in-field sampling of organic
pollutants in (industrial) waste water;
Development of on-line fiels sampling, extraction and
analysis systems for the determination of
micropollutants in waste water.
Development of multidimensional separation systems
for peptides and protein in biological samples,
including bio-specific detection and on-line digestion
approaches.
Teaching Activities at Utrecht University:
Qualitative and quantitative analysis of inorganic
compounds;
Introduction in titrimetric determination methods
(acid-base, complexometric and redox titrations) and
polarimetric, refractive-index, and melting-point, etc.
measurements;
Spectrophotometric determination methods (UVvisible, fluorescence, IR, NMR, MS, AAS/AES).
Teaching Activities at Leiden University:
-
-
Development of bioanalytical strategies (e.g., sample
preparation procedures, chromatographic methods including automation and column-switching
techniques, derivatization procedures, detection
principles);
Spectrophotometric determination methods (see
above);
Electrochemistry (amperometry), chromatography (LC,
GC, TLC), immunoassays, modern luminescence
techniques
(e.g.,
bioluminescence,
Raman
spectroscopy,
laser-induced
fluorescence),
enantiomeric separations and electromigration
techniques (e.g., electrophoresis, electrofocussing,
isotachophoresis, CZE).
Teaching Activities at the Vrije Universiteit:
Development of bioanalytical strategies (see teaching
activities Leiden);
Practical
courses
in
chromatography and
environmental analysis;
Separation
sciences
(e.g.,
chromatography,
electrophoresis, reaction / detection, sample
preparation);
Electrochemical analysis;
Environmental analysis (e.g., chromatography, MS,
AAS/AES);
Environmental chemistry (e.g., risk assessment of
chemicals);
Field excursions (Dutch coastal waters) in
environmental chemistry.
Master courses on: Principles of Analytical Sciences,
Bio-Analytical Chemistry, Separations Sciences.
Specialized courses on: Pharmaceutical Chemistry,
Drug Stability, Immunochemistry, Communication
Skills.
Ph.D. Students:
Copromotor of:
C. de Ruiter, ‘Pre and post-column fluorescence
derivatization in LC: Ion-pair extraction, phasetransfer catalysis and photochemistry’, Vrije
Universiteit, Amsterdam, November 1989;
A. Farjam, ‘The use of immobilized antibodies for
selective on-line sample preparation in LC and GC,
Vrije Universiteit, Amsterdam, February 1991;
-
-
-
-
-
-
-
-
E.R. Brouwer, ‘On-line trace enrichment in LC for the
determination of organic micropollutants in surface
water’, Vrije Universiteit, Amsterdam, February 1994;
N.C. van de Merbel, ‘On-line membrane-based sample
preparation for LC’, Vrije Universiteit, Amsterdam,
December 1994;
B.N. Zegers, ‘The use of GC detectors in packedcapillary LC and SFC’, Vrije Universiteit, Amsterdam,
April 1995;
A.J.G. Mank, ‘Diode laser-based detection methods in
analytical chemistry’, Vrije Universiteit, Amsterdam,
September 1995;
J. Slobodnik, ‘Automation of hyphenated LC and GC
systems in environmental analysis, Vrije Universiteit,
Amsterdam, March 1996;
O.M.
Steijger,
‘Chemiluminescence
and
electrochemiluminescence: Generation, optimization
and application’, University of Utrecht, Utrecht, June
1998.
J.R. Veraart, ‘Automated pretreatment of biological
samples for capillary electrophoresis’, Vrije
Universiteit, Amsterdam, November 2000.
J.C.M. Waterval , ‘Strategies in the Bioanalysis of
Peptides and Proteins’, University of Utrecht, Utrecht,
November 2000.
Member of Examination Committee of:
W.M.G.M. van Loon, ‘Isolation and quantitative
pyrolysis-mass
spectrometry
of
dissolved
chlorolignosulphonic acids, University of Amsterdam,
Amsterdam, September 1992;
K. Wuchner, ‘Preparation et analyse de
micropollutants organiques dans de echantillons
environmentaux (Extraction par fluide supercritique:
Preconcentration et analyse en ligne LC)’, Institut
National Polytechnique, Toulouse, Frebruary 1994;
X. Huang, ‘Electrochemical detection in LC and CZE
using electrodes modified with electrocatalysts’,
University of Amsterdam, Amsterdam, September
1995;
E. Pocurull Aixalà, ‘Extractió en fase sòlida aplicada
al la determinció de compostos fenòlics’, Universitet
Rovira I Virgili, Tarragona, February 1996;
J.L.E. Reubsaet, ‘Chemical degradation of some
biologically active peptides’, University of Utrecht,
Utrecht, September 1996;
-
-
-
-
-
-
A. Tivesten, ‘Fluorogenic labelling of amino acids and
peptides in CZE’, Göteborg University, Göteborg,
March 1997;
M.A. Hoitink, ‘Stability of gonadorelin and related
compounds’, University of Utrecht, Utrecht, June
1998;
R. Zhu, ‘Post-column reaction detection in CZE’,
University of Amsterdam, Amsterdam, June 1998.
J. Norberg, ‘Non-porous Membrane Extractions in
Contempory Analysis’ University of Lund, Lund,
April 2000.
M. van Bruijnsvoort, University of Amsterdam,
Amsterdam, July 2001.
R. Stol, Amsterdam, September 2001.
M. Bouma, ‘Pharmaceutical development of the novel
metal-based anticancer agents NAMI-A and AP5280’,
Utrecht University, Utrecht, September 2002.
E.J. Lozano, ‘Desarrollo y Optimización de métodos
de separación y análisis de quinolonas en materiales
biológicos por electroforesis capilar, Universitat de
Barcelona, Barcelona, July 2003.
Jonathan Raven Eric Thabano, ‘Methodology
development for analysis and monitoring of water and
wastewater quality in Gaborone dam catchment area’,
University of Botswana, Gaborone, 2004.
International Activites / Contacts:
-
International Joint Research Projects:
Co-ordinator EC project ‘On-line sample-handling-GC
for the analysis of environmental samples’ (September
1994 - September 1998). Partners: Vrije Universiteit,
Amsterdam, The Netherlands and Rani Durgavati
University, Jabalpur, India;
Co-ordinator EC project ‘On-line field sampling and
monitoring in combination with automated
determination of micropollutants in industrial and
communal waste water’ (January 1998 - January
2001). Partners: Vrije Universiteit, Amsterdam, The
Netherlands; CSIC-CID, Barcelona, Spain; Ministry of
Transport, Public Works and Water Management,
Lelystad, The Netherlands; Aristotle University,
Thessaloniki, Greece; Technical University, Vienna,
Austria and Hyder Consulting Limited, Runcorn, UK.
-
(Inter)national Societies / Associations:
Member of the Royal Dutch Chemical Society
(KNCV);
-
-
-
-
Secretary of the Section ‘Pharmaceutical and
Biomedical Analysis (FABIAN)’ of the KNCV;
Advisor Training Dutch Society of Clinical
Pharmaceutical Technicians in Hospital Pharmacies
(NVK-FAZ);
Secretary of the Section ‘Separation Sciences (WGS)’
of the KNCV;
Member of the Chromatographic Society (UK);
Member of the Board of Trustees-at-large of the
International Association for Pharmaceutical and
Biomedical Analysis (USA);
Acting Secretary of the European Group of
Pharmaceutical and Biomedical Chemistry (EGPBC).
International Activities:
Member (1987, 1994) of the Scientific Committee of
the International Luminescence Symposium (Ghent,
Belgium);
Member of the Organizing Committee of the 18th and
20th International Symposium on Chromatography
(Amsterdam, September 1990; Bournemouth, June
1994);
Member of the Scientific Committee of the 6th and
10th International Symposium on Pharmaceutical and
Biomedical Analysis (St. Louis, May 1995;
Washington, May 1999) and co-chairman of the 8th
International Symposium on Pharmaceutical and
Biomedical Analysis (Orlando, May 1996);
Member of the Scientific Committee of the 1st, 2nd
and 3rd International Symposium and Short Course on
Separation Sciences (Bhopal, Jabalpur, Bhopal, India,
1996 - 1999);
Member of the Organizing and Co-ordinating
Committee of the 6th Symposium of Chemistry and
fate of Modern Pesticides (Amsterdam, June 1997);
Member of the Organizing Committee of Drug
Analysis’98 (Brussels, May 1998);
Member of the Organizing Committee of the 9th
International Meeting on Recent Developments in
Pharmaceutical Analysis (RDPA’01) (Lipari, June
2001).
Member of the Organizing and Scientific Committee
of International MM 2003 Symposium on the
Separation and Characterization of natural and
Synthetic Macromolecules (Amsterdam, February
2003).
-
Member of the Organizing Committee of the 8th
International Symposioum on drug Analysis, Namur,
May 2006.
-
Co-chairman of the Organizing and Scientific
Committee of the 1st International Symposium on
Micropollutants: Environmental Effects and Social
Implications (ISM’98) (Amsterdam, May 1998);
Co-chairman of the Organizing and Scientific
Committee of the 1st International Symposium on
Separations in the Biosciences (SBS’99) (Amsterdam,
March 1999);
Member of the Scientific Committee of the 23rd
International Symposium on High Performance Liquid
Phase Separations and Related Techniques (HPLC’99)
(Granada, June 1999) and co-chairman of the
Organizing and Scientific Committee of the 25th
International Symposium on High performance Liquid
Phase Separations and Related Techniques
(HPLC’2001) (Maastricht, June 2001);
Co-chairman of the Scientific Committee of the 8th
International Meeting on Recent Developments in
Pharmaceutical Analysis (RDPA’99) (Rome, June
1999).
Co-chiarman of “Introductory Course on Drug
Research”,
LACDR
Research
School,
Noordwijkerhout, August 2004, August 2005.
-
-
-
-
-
-
-
Treasurer of Organizing Committee of 4th International
Symposium on Separations in the BioSciences
(SBS’05), Utrecht, September 2005.
Member of Scientic Committee of Drug Analysis 2006.
Editor of Chromatographia;
Member of the Editorial Board of Current Analytical
Chemistry,
International
Journal
of
BioChromatography, Journal of Pharmaceutical and
Biomedical Analysis and LC.GC International;
Referee for: Analytica Chimica Acta, Analytical and
Bioanalytical Chemistry, Analyst, Chromatographia,
Clinical Chemistry and Laboratory Medicine, Current
Analytical Chemistry, European Journal of
Pharmaceutical Sciences, International Journal of BioChromatography,
International
Journal
of
Environmental and Analytical Chemistry, Journal of
American
Chemical
Society,
Journal
of
Chromatography A and B, Journal of Membrane
Science, Journal of Pharmaceutical and Biomedical
Analysis, LC.GC, International, Pharmaceutical
Research, Talanta and Trends in Analytical Chemistry.
Management activities:
At Utrecht University I was a member of the board of
the Division of Analytical Pharmacy and both at
Utrecht and Leiden University I was a member of
several Committees (e.g. teaching committee);
At the Vrije Universiteit I am a member of the board
of the Faculty of Chemistry and the board of the
Department of Analytical Chemistry, chairman of the
Teaching Committee Chemistry, Pharmacochemistry
and Environmental Sciences, chairman of the Teaching
Evaluation and Program Evaluation committees.
Awards:
In 1990 I received the ‘Jubilee medal’ of the Chromatographic
Society (UK).
SUMMARY CURRICULUM VITAE
Research Interest:
Development of automated procedures for the determination of all kinds of analytes in
biomedical, pharmaceutical, and environmental samples using sophisticated chromatographic and
electrophoretic separation techniques in combination with on-line sample preparation,
derivatization, and reaction-detection systems. The emphasis is on the development of new online sample preparation techniques (e.g., dialysis, immunoaffinity, solid-phase isolation, columnswitching, supercritical fluid extraction), automated pre-column derivatization techniques,
combined separation techniques (e.g., chromatography and electrophoresis), detection techniques
(e.g. laser-induced fluorescence), and post-column derivatization techniques.
Summary List of Publications
- (Co-) author of ca. 130 original scientific papers.
- (Co-)author of ca. 35 review papers.
- (Co-) author of ca. 20 book chapters.
- (Co-) editor of 3 books (including dissertation).
- (Co-) presentor of ca. 225 oral presentations (including workshops) at national and/or
international meetings, seminars and symposia.
- (Co-) author of ca. 150 posters at national and/or international meeting, seminars and
symposia.
- (Co-) authors of ca. 20 abstracts published in international scientific journals.
- (Co-) author of ca. 25 special publications in scientific journals like meeting reports and
book reviews.
- (Co-) author of ca. 55 research reports / proposals which are not published in regular
scientific journals.
- Supervisor of ca. 100 research colloquia.
Most important PUBLICATIONS
ORIGINAL PAPERS
001
H. Roseboom, R.H.A. Sorel, H. Lingeman, R. Bouwman, A Rapid Gas
Chromatographic Method for the Determination of Nalidixic Acid in Plasma, J.
Chromatogr., 163 (1979) 92-95.
002
W.J.M. Underberg, H. Lingeman, Aspects of the Chemical Stability of
Mitomycin and Porfiromycin in Acidic Solutions, J. Pharm. Sci., 72 (1983)
549-553.
003
H. Lingeman, A. Hulshoff, W.J.M. Underberg, F.B.J.M. Offermann, Rapid,
Sensitive and Specific Derivatization Methods with 9-(Hydroxymethyl)anthracene for the Fluorimetric Detection of Carboxylic Acids prior to
Reversed-Phase HPLC Separation, J. Chromatogr., 290 (1984) 215-222.
004
C.M.B. van den Beld, H. Lingeman, G.J. van Ringen, U.R. Tjaden, J. van der
Greef, Laser-Induced Fluorescence Detection in Liquid Chromatography after
Preliminary Derivatization of Carboxylic Acid and Primary Amino Groups,
Anal. Chim. Acta, 205 (1988) 15-27.
005
H. Irth, G.J. de Jong, H. Lingeman, U.A.Th. Brinkman, Liquid
Chromatographic Determination of Azidothymidine (AZT) in Human Plasma
Using On-line Dialysis and Preconcentration on a Silver(I)-loaded Stationary
Phase, Anal. Chim. Acta, 236 (1990) 165-172.
006
A. Farjam, A.E. Brugman, A. Soldaat, P. Timmerman, H. Lingeman, G.J. de
Jong, R.W. Frei, U.A.Th. Brinkman, Immuno Precolumn for Selective Sample
Pretreatment in Column Liquid Chromatography: Immunoselective Desorption,
Chromatographia, 31 (1991) 469-477.
007
N.C. van de Merbel, J.M. Teule, H. Lingeman, U.A.Th. Brinkman, Dialysis as
an On-Line Sample-Pretreatment Technique: Influence of Experimental
Variables Using Benzodiazepines as Model Compounds, J. Pharm. Biomed.
Anal., 10 (1992) 225-233.
008
J. Slobodnik, E.R. Brouwer, R.B. Geerdink, W.H. Mulder, H. Lingeman,
U.A.Th. Brinkman, Fully Automated On-Line Liquid Chromatographic
Separation System for Polar Pollutants in Various Types of Water, Anal. Chim.
Acta, 268 (1992) 55-65.
009
A.J.G. Mank, E.J. Molenaar, H. Lingeman, C. Gooijer, U.A.Th. Brinkman,
N.H. Velthorst, Visible Diode-Lasers Induced Fluorescence Detection in Liquid
Chromatography after Pre-Column Derivatization of Thiols, Anal. Chem., 65
(1993) 2197-2203.
010
N.C. van de Merbel, P. Zuur, M. Frijlink, J.J.M. Holthuis, H. Lingeman,
U.A.Th. Brinkman, Automated Monitoring of Amino acids during
Biotechnological Processes using On-Line Ultrafiltration and Column Liquid
Chromatography: Application to Fermentation Medium Improvement, Anal.
Chim. Acta, 303 (1995) 175-185.
011
J.R. Veraart, S.J. Kok, J.M. te Koppele, C. Gooijer, H. Lingeman, U.A.Th.
Brinkman and N.H. Velthorst, The Separation of two Collagen Crosslinkers
with Capillary Electrophoresis and Laser-Induced Fluorescence Diode-array
Detection, Biomedical Chromatography, 12 (1998) 226 - 231.
REVIEW PAPERS
001
H. Lingeman, W.J.M. underberg, A. Takadate, A. Hulshoff, Fluorescence
Detection in High Performance Liquid Chromatography, J. Liq. Chromatogr., 8
(1985) 789 - 874.
002
H. Lingeman, R.D. McDowall, U.A.Th. Brinkman, Guidelines for Bioanalysis
using Column Liquid Chromatography, Trends Anal. Chem., 10 (1991) 48.
003
A.J.G. Mank, H. Lingeman, C. Gooijer, Diode Laser Induced Fluorescence
Detection in Chromatography, Trends Anal. Chem., 11 (1992) 210.
004
N.C. van de Merbel, H. Lingeman, U.A.Th. Brinkman, Sampling and
Analytical Strategies in On-line Bioprocess Monitoring and Control, J.
Chromatogr. A, 725 (1996) 13 - 27.
005
H. Lingeman, S.J.F. Hoekstra, Particle-loaded Membranes for Sample
Concentration and/or Clean-up in Bioanalysis, J. Chromatogr. B, 689 (1997)
221 - 237.
006
H.A. Bardelmeijer, J.C.M. Waterval, H. Lingeman, R, van ‘t Hof, A. Bult,
W.J.M. Underberg, Pre- On- and Post-Column Derivatization in Capillary
Electrophoresis, Electrophoresis, 18 (1997) 2214 - 2227.
BOOK CHAPTERS
001
A. Hulshoff, H. Lingeman, Fluorescence Detection in Chromatography, in S.G.
Schulman (Ed.), Molecular Luminescence Spectroscopy: Methods and
Applications - Part I, Wiley, New York, 1985.
002
C.M.B. van den Beld, H. Lingeman, Laser-Based Detection in Liquid Chromatography with Emphasis on Laser-induced Fluorescence Detection in W.R.G.
Baeyens, D. De Keukeleire, K. Korkidis (Eds.), Luminescence Techniques in
Chemical and Biomedical Analysis, Dekker, New York, 1990.
003
H. Lingeman, C. Gooijer, N.H. Velthorst, U.A.Th. Brinkman, Chromatography
- Fluorescence / Luminescence Spectroscopy in A,M.C. Davies and C.S.
Creaser (Eds.), Analytical Applications of Spectroscopy II, Royal Society of
Chemistry, Cambridge, 1991.
004
C. de Ruiter, H. Lingeman, Analytical Applications of Phase-Transfer
Catalysis, in Y. Sasson, R. Neumann (Eds.), Handbook of Phase-Transfer
Catalysis, Blackie Academic & Professional, London, 405 - 423.
BOOKS
001
H. Lingeman, Selective Pre-Chromatographic Derivatization Methods for
Carboxylic Acids (high-performance liquid chromatography with fluorescence
detection and gas-liquid chromatography with nitrogen-phosphorous
detection), Thesis, Utrecht, April 1986.
002
H. Lingeman, W.J.M. Underberg (Eds.), Detection-Oriented Derivatization
Techniques in Liquid Chromatography, Dekker, New York, January 1990.