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4th European CellAid-Symposium Cell Therapies for a Cure of Autoimmunity German Academy of Sciences Leopoldina March 18 - 20, 2009 , Kongresshotel Potsdam “Am Templiner See” Potsdam (near Berlin), Germany ¾ Chairs Gerd Burmester, Berlin, Germany Andreas Radbruch, Berlin, Germany ¾ Local Organising Committee, Berlin Wolfram Ebell Falk Hiepe Elke Luger Andreas Radbruch Andreas Thiel ¾ Support Leopoldina, EULAR, EFIS, DFG, DRFZ, Charité Becton-Dickinson, Miltenyi, Roche 1 Preliminary Scientific Program Wednesday, March 18, 2009 1.00 pm Arrival, registration, media transfer 2.00 pm Andreas Radbruch (or G-R Burmester) Opening remarks From Pathomechanisms to Cellular Targets Chair: NN 2:15 pm Christian Jorgensen, Nice genetic biomarkers for selected biotherapies in RA 2:45 pm Rick Holmdahl, Stockholm NN 3:15 pm Steffen Gay, Zürich Epigenetics in Rheumatic Diseases 3:45 pm Bruno Kyewski, Heidelberg How central is central tolerance? 4:15 pm Tobias Bopp Mechanisms of nTreg-mediated suppression 4:45 pm Marcel van den Brink, New York Off-the-shelf adoptive cell therapy with T cell precursors across MHC barriers 5:15 pm Matthias Edinger, Regensburg Adoptive Treg cell transfer in stem cell transplantation 5:45 pm Coffee brake B cells and Plasma Cells Chair: Günter Steiner, Wien 6:15 pm David Tarlinton, Melbourne Antagonising Pro-Survival Pathways to Modulate Immune Response 6:45 pm Simon Fillatreau, Berlin Activated B cells in immunity: the case for a regulatory role 7:15 pm Reinhard Voll, Erlangen NN 8.00 pm Dinner-Buffet 2 Thursday, March 19, 2009 Proinflammatory and regulatory T cells Chair: NN 9:00 am Francesco Annunziato, Florence Human IL-17-producing cells: origin and development 9:30 am Pierre Miossec, France IL-17 and Th17: contribution to arthritis chronicity 10.00 am Hyun-Dong Chang, Berlin The pro-inflammatory immunological memory 10:30 am Ken Smith, Cambridge A CD8 T cell transcription signature predicts prognosis in autoimmune disease 11:00 am Coffee break 11:30 am Alf Hamann, Berlin Stability and Epigenetic of Tregs 12:00 am Berent Prakken, Utrecht Regulatory T cells in autoimmunity: good guys, bad guys, or incompetent bystanders? 12:30 pm Hans Koenen, Nijmegen Human regulatory T cell expansion, antigenspecificity and plasticity; lessons learned from allo-antigens 13:00 pm Lunch MSC, NK-cells & other cells Chair: NN 14:00 pm Francesco Dazzi, London The challenge of mesenchymal stem cell therapy for autoimmune diseases 14:30 pm NN 15:00 NN 15:30 pm NN 16:00 pm Coffee brake 3 Lessons from Clinical Stem Cell Reconstitutions Chair: NN 16:30 pm Wietse Kuis, Utrecht The role of stemcell transplantation and mesenchymal stemcells in pediatric rheumatology 17:00 pm Ricardo Saccardi, Florence Haematopoietic stem cell transplantation in autoimmune diseases: The EBMT Experience 17:30 pm Renate Arnold, Berlin NN 18:00 pm NN 18:00 pm Jaap van Laa, UK Risks and benefits of stem cell transplants, lessons learned in systemic sclerosis Friday, March 20 2009 Novel Concepts of Cell-Based Therapies Chair: Andreas Thiel, Berlin 9.00 am Alexander Scheffold Self-limitation of proinflammatory T cells as therapeutic strategy 9:30 am Alan Tyndall, Basel Mesenchymal stem cells in autoimmune disease treatment 10:00 am Petra Reinke, Berlin Adoptive T cell therapy - chance and challenges 10:30 am Coffee brake 11:00 am Andreas Grützkau, Berlin To be on the safe side: Multiparametric immunophenotyping of peripheral blood cells for monitoring of cell-based therapies 11:30 am NN 12:00 am NN 12:30 pm Lunch 13:30 pm Arndt von Hoeveler 4