Download Profile Adrian Hayday

Profile Adrian Hayday
Brief CV-Adrian Hayday
Brief CV: A graduate of Queen's College Cambridge, Professor Hayday
obtained a PhD in Tumour Virology in 1978 and undertook post-doctoral
training at MIT. In 1998, after 13 years on the faculty of the
Departments of Biology and Immunobiology at Yale University, he returned
to Guy’s Hospital London, to the Kay Glendinning Professor & Chair in the
Department of Immunobiology at King's College. He has published over 150
papers, and among other things, contributed to the cloning of the T-cell
receptor (TCR), in particular the unanticipated TCR-gamma chain genes.
Together with Professor Robert Tigelaar (Yale) and other long-standing
collaborators, Professor Hayday has succeeded in identifying critical roles
for gamma-delta T cells in resistance to solid tumours, and in
immunoregulation, particularly within tissues. In 1997, he received the
William Clyde DeVane Medal, Yale College's highest honour for teaching
and scholarship, and he was elected a fellow of the Academy of Medical
Sciences in 2002. He advises several scientific bodies, including the
Wellcome Trust where he chairs the funding committee in Basic Immunology
and Infectious Diseases, and sits on the Strategy Committee.
Main Line of Research
The development and function of tissue immunosurveillance
Adrian Hayday's research focuses on how the immune system interacts with
cells in tissues, both at the afferent stage (when tissues are first infected or
disrupted), and at the effector stage (when the systemic cells infiltrate a
tissue). His team studies intraepithelial T cells that collectively compose one of
the largest, yet least well understood, T cell compartments in the body. Among
these, cells expressing gd T cell receptors (TCRs) are not restricted to MHC
(by contrast to conventional T cells), and respond rapidly and oligoclonally
during primary immune responses, contributing to afferent events and also
regulating subsequent effector infiltrates. Dr Hayday has proposed that these
cells are prototypic of a broad range of “unconventional T cells” that
constitutively associate with tissues and that are particularly relevant to
immunosurveillance and inflammatory diseases. Current studies use transgenic
mice to examine how such cells respond to specific molecular hallmarks of
tissue dysregulation. These run in parallel with studies that have identified
novel molecules expressed by thymic stroma, and molecules expressed by other
thymocytes, that collectively dictate that a T cell progenitor will differentiate
into a tissue-associated, unconventional T cell. In addition, Dr Hayday and
collaborators are exploiting their knowledge of gamma delta T cells in clinical
trials for immunotherapy of solid tumours.
Publications-Last 3 years – Adrian Hayday
Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire
by a thymic stromal determinant. Lewis JM, Girardi M, Roberts SJ, Barbee SD,
Hayday AC, Tigelaar RE. Nat Immunol. 2006 Aug;7(8):843-50. Epub 2006 Jul 9.
1.
Environmentally responsive and reversible regulation of epidermal barrier
function by gammadelta T cells. Girardi M, Lewis JM, Filler RB, Hayday AC,
Tigelaar RE. J Invest Dermatol. 2006 Apr;126(4):808-14.
2.
Orchestrated leak provokes a thymus reassessment. Hayday A, Nat
Immunol. 2006 Jan;7(1):9-11.
3.
Sustained localized expression of ligand for the activating NKG2D
receptor impairs natural cytotoxicity in vivo and reduces tumor
immunosurveillance. Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM,
Tigelaar RE, Girardi M, Hayday AC. Nat Immunol. 2005 Sep;6(9):928-37. Epub
2005 Aug 14.
4.
The integration of conventional and unconventional T cells that
characterizes cell-mediated responses. Pennington DJ, Vermijlen D, Wise EL,
Clarke SL, Tigelaar RE, Hayday AC. Adv Immunol. 2005;87:27-59. Review.
5.
Immunosurveillance by gammadelta T cells: focus on the murine system.
Chem Immunol Allergy. 2005;86:136-50. Review. Girardi M, Hayday AC.
6.
Gammadelta T cell development--having the strength to get there.
Pennington DJ, Silva-Santos B, Hayday AC. Curr Opin Immunol. 2005
Apr;17(2):108-15. Review.
7.
Lymphotoxin-mediated regulation of gammadelta cell differentiation by
alphabeta T cell progenitors. Silva-Santos B, Pennington DJ, Hayday AC.
Science. 2005 Feb 11;307(5711):925-8. Epub 2004 Dec 9.
9.
A comparative analysis of RNA targeting strategies in the thymosin beta
4 gene. Gibbons DL, Shashikant C, Hayday AC. J Mol Biol. 2004 Sep
24;342(4):1069-76.
8.
Integrated immune responses to infection -cross-talk between human
gammadelta T cells and dendritic cells. Eberl M, Jomaa H, Hayday AC.
Immunology. 2004 Jul;112(3):364-8. No abstract available.
10.
Characterizing the protective component of the alphabeta T cell
response to transplantable squamous cell carcinoma. Girardi M, Oppenheim D,
Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC. J Invest Dermatol.
2004 Mar;122(3):699-706.
11.