Download Microbiology 204 - UCSF Immunology Program

Microbiology 204
Antigen Presentation and MHC Molecules
Art Weiss ([email protected])
October 14, 2015
* required reading
Reading List
Some recent important publications
Saric T et al. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims
precursors to MHC class I-associated peptides. Nat Immunol 3:1169-1176, 2002.
Stoll S et al. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes.
Science 296:1873-6, 2002.
Rehm A et al. Human cytomegalovirus gene products US2 and US11 differ in their
ability to attack major histocompatibility class I heavy chains in dendritic cells. J Virol
76:5043-50, 2002.
Lilley BN, and Ploegh HL. A membrane protein required for dislocation of
misfolded proteins in the ER. Nature 429:834-840, 2004.
Lazarski CA et al. The kinetic stability of MHC class II:peptide complexes is a key
parameter that dictates immunodominance. Immunity 23:29-40, 2005
Shin J-S et al. Surface expression of MHC class II in dendritic cells is controlled by
regulated ubiquitination. Nature 244:115-118, 2006.
Fallang L-E, et al. Differences in the risk of celiac disease associated with HLADQ2.5 or HLADQ2.2 are related to sustained gluten antigen presentation. Nature
Immunol, 10:1096-1102, 2009.
*Illing, P.T., et al. Immune self-reactivity triggered by drug-modified HLApeptide repertoire. Nature. 486:554-558.
*Kincaid, E., et al. Mice completely lacking immunoproteasomes show major
changes in antigen presentation. Nat. Immunol. 13:129-135, 2012.
Beisner, DR, et al., The intramembrane protease Sppl2a is required for B cell and
DC development and survival via cleavage of the invariant chain. J. Exp. Med. 210:2330, 2013.
Useful review articles
Antigen processing and presentation:
A series of reviews on Antigen Processing and Presentation was the focus of an
entire volume of Immunological Reviews: Volume 207, 2005.
In addition, the following are useful:
Itano AA and Jenkins MK. Antigen presentation to naïve CD4 T cells in the lymph
node. Nature Immunol. 4:733-739, 2003.
Porcelli SA, and RL Modlin. The CD1 system: antigen-presenting molecules for T
cell recognition of lipids and glycolipids. Annu. Rev of Immunol 17:297–329, 1999.
Boes M, and Ploegh, HL. Translating cell biology in vitro to immunity in vivo.
Nature 430:264-271, 2004.
Trombetta A and I Mellman. Cell biology of antigen processing in vitro and in vivo.
Annu. Rev. Immunol. 23:975-1028, 2005
Vyasm JM, Van der Veen AG, and Ploegh, HL. The known unknowns of antigen
processing and presentation. Nature Rev. Immunol. 8:607-618, 2008.
Zajonc DM, and Kronenberg M. Carbohydrate specificity of the recognition of
diverse glycolipids by natural killer T cells. Immunol. Rev. 230:188-200, 2009.
Joffre OP, Segura E, Savina A, and Amigorena S. Cross presentation by dendritic
cells. Nature Rev. Immunol. 12:557-569.
Basler, M, Kirk, CJ, and Groettrup, M. The immunoproteasome in antigen
processing and other immunologic functions. Curr. Opin. Immunol. 25:74-80, 2013.
*Blum, JS, Wearsch, PA, and Cresswell, P. Pathways of antigen presentation.
Annu. Rev. Immunol. 31:443-473, 2013.
Mellins, ED, and Stern LJ. HLA-DM and HLA-DO, key regulators of MHC-II
processing and presentation. Curr. Opin. Immunol. 26:115-122. 2014.
Roche PA, and Furuta K. The ins and outs of MHC class II-mediated antigen
processing and presentation. Nature Rev. Immunol. 15:203-216. 2015.
MHC:
Alfonso C and L Karlsson. Nonclassical MHC class II molecules. Annu Rev of
Immunol 18:113-142, 2000.
Klein J and A Sato. The HLA system. New Eng J Med 343:702-709 and 782-786,
2000.
Madden DR. The three dimensional structure of peptide-MHC complexes. Annu Rev
of Immunology 13:587–622, 1995.
Parham P, and T Ohta. Population biology of antigen presentation by class I MHC
molecules. Science 272:67–74, 1996.