Download Vicente G. Villarrubia, MD, PhD

CURRICULUM VITAE
(Summary, april 2006)
Vicente G. Villarrubia, M.D., PhD
Education
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Doctor in M edicine & Surgery (Spain); Specialty in Immunology (France); Specialty
in Family & Community M edicine (Spain); M aster in Epidemiology & Public Health
(Spain);
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Extraordinary Prize of Doctor in M edicine (Spain).
Actual Position
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General Director & Chairman of the R&D and innovation Dpt., BIOAVEDA, S.L.,
Jaén, Spain;
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Invited Professor of Immunology to several Spanish & SouthAmerican Universities.
Professional background
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Research fields: Inmunopathology of skin cancer (melanoma) & hepatic carcinoma;
Links between innate and adaptive immunity; Inmunology of childhood and elderly;
Immunity, infection, cancer & vaccines.
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R&D of Immunomodulators (AM 3, EPL [Polypodium leucotomos extract], VRCTC310 [secreted Phospolipase A2]).
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R&D+i on products from Healthy Plants: Extra Virgin Olive Oil (oHo ) and others, in
the fields of:
o
nutrition/inflammation
o prevention and treatment of cancer, infections and metabolic illnesses with
cardiovascular repercussion
o sun protection.
Merits & Honours
Prize “Anticancer Research” (Greece); Prize Carlos M anero Pineda to Tumor Immunology
(Spain); President of the “1st. Symp on AIDS related neoplasias”, Toledo (Spain);
Chairman Int Symp on AIDS-related Neoplasias; Chairman
World
Congress
on
Inflammation: Italiy, Swizertland; Chairman Int Congr on Vitiligo, Siria; Invited
Lecturer Int Cong on “Inmunology of the Elderly (ImAginE)”. Córdoba, (Spain);
Prize to the best publication in Rev Esp de Geriatría y Gerontología. 2001; Honour
M ember of the Andalucía Committe for Ecologic A griculture.
S ome Publications:
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Villarrubia VG, et al. New vaccines and the immune response. I. The immunologic
memory. Humoral vs cellular response. M ed Clin (Barc) 1996; 107:146-54.
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Villarrubia VG, et al. New vaccines and the immune response. II. The environment
of the antigen presentation. Adjuvants as inducers of T-cell responses. M ed Clin
(Barc) 1996; 107:185-96.
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Villarrubia VG, et al. Immune alterations provoked by ultraviolet radiation. Its
pathogenic relationship with photoaging and skin cancer (Spanish). Piel 1996; 11:46270.
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Villarrubia VG, et al. The immunosenescent phenotype in mice and humans can be
defined by alterations in the natural immunity. Reversal by immunomodulation with
oral AM 3. Immunopharmacol & Immunotoxicol 1997;19:53-74.
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Rayward J, Villarrubia VG, et al. An extract of the fern Polypodium leucotomos
inhibits human peripheral blood mononuclear cells proliferation in vitro. Int J
Immunopharmacol 1997; 19: 9-14.
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Villarrubia VG. Inmunology of malignant melanoma (spanish). Dermatol & Cosmet
1996; 6: 49-53.
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González S , Pathak MA, Cuevas J, Villarrubia VG, Fitzpatrick TB. Topical or
oral administration with an extract of Polypodium leucotomos prevents acute sunburn
and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in
human skin. Photodermatol Photoimmunol Photomed 1997; 13:50-60.
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Costa LA, et al, and Villarrubia VG. Tumor regression of advanced carcinomas
following intra-and/or peri-tumoral inoculation with VRCTC 310: preliminary report
of two cases. Immunopharmacol & Immunotoxicol 1998; 20:15-25.
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Costa LA, Miles H, Araujo CE, Villarrubia VG. A pilot comparative study
withVRCTC-310 for the treatment of haevely pretreated advanced cancer patients.
17th Int Cancer Congress UICC 1998; 149:1-4.
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Villarrubia VG, et al. Immune/inflammatory pathogeny of asthma. Therapeutic
implications (Spanish). Allergol et Immunopathol 1999; 27:213-31.
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Villarrubia VG, et al. Immunopathogeny of elderly: the deterioration of inat e
immunity and its effects on specific immunity (spanish). Rev Esp Geriatr Gerontol
2000; 35:30-42.
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Córdova
A,
Villarrubia VG, Prieto A,
Alvarez-Mon M. AM 3 shows
antiinflammatory activities in elite sportsmen. En: Proc 5th World Congress on
Trauma, Shock, Inflammation and Sepsis. Edit. Eugen Faist. M onduzzi edit. Bologna,
Italy 2000; pp: 295-9.
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Gonzalez S , et al, and Villarrubia VG. An extract of the fern Polypodium
leucotomos modulates Th1/Th2 cytokines balance in vitro and appears to exhibit antangiogenic activities in vivo: pathogenic relationships and therapeutic implications.
Anticancer Res 2000; 20:1567-76.
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Prieto A, Reyes E, Bernstein ED, Martínez B, Montserrat J, Izquierdo JL, Callol
L, de Lucas P, Alvárez-S ala R, Alvárez-S ala JL, Villarrubia VG, Alvárez-Mon
M. Defective natural killer and phagocytic activities in chronic obstructive pulmonary
disease are restored by glicophosphopeptical (Inmunoferón). Am J Respir Crit Care
M ed 2001; 163:1578-83.
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Villarrubia VG, et al. Epidemiology and immunopathogeny of non-melanoma skin
cancer. The initiating and promoting role of HPV (Spanish). Piel 2001; 16:428-38.
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Villarrubia VG, et al. Human Papiloma Virus and ultraviolet radiation: “ les liasons
dangereuses” for the skin (spanish). Piel 2001; 16:494-505.
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Villegas FR, Coca S , Villarrubia VG, et al. Prognostic significance of tumor
infiltrating natural killer cells in patients with squamous cell lung cancer. Lung Cancer
2002; 35:23-8.
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Perez-García R, Perez-Garcia A, Verbeleen D, Bernstein ED, Villarrubia VG,
Alvarez-Mon M. AM 3 (Inmunoferon) as an adjuvant to hepatitis B vaccination in
hemodialysis patients. Kidney Int 2002; 61:1845-52.
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Villarrubia VG, Costa L, Díez R. Secreted A2 phospholipases (sPLA2) Friends or
foes? Actors of the bacteria and the anti-HIV resistance? M ed Clin 2004; 123:749-57.
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Reyes E, Jaén P, Heras ED, Eusebio ED, Carrión F, Cuevas J, González S ,
Villarrubia VG, et al. Systemic immunomodulatory effects of Polypodium
leucotomos as an adjuvant to PUVA therapy in generalized vitiligo: A pilot study.
Journal Dermatology Sciences 2006 Jan 16; [Epub ahead of print].
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Villarrubia VG. Health impact of maternal breastfeeding. Influence of extra virgin
olive oil. (spanish). In: http://www.bioaveda.com/salud.html
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Villarrubia VG, Gonzalez P, Torres Morales J. Oilenes* and pesticides: A furtive
attack to the olive oil-related health? Implications in cancer. Asthma and the
immunologic hygiene hypothesis (Spanish). In: http://www.bioaveda.com/salud.html
Correspondence:
Dr. Vicente G. Villarrubia
Director Dpt. I+D+i
BIOAVEDA, S.L
C/ Sauce 28
Urb. Azahar
23006-Jaén (España)
E-mail: [email protected]
web: www.bioaveda.com
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