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CURRICULUM VITAE (Summary, april 2006) Vicente G. Villarrubia, M.D., PhD Education • Doctor in M edicine & Surgery (Spain); Specialty in Immunology (France); Specialty in Family & Community M edicine (Spain); M aster in Epidemiology & Public Health (Spain); • Extraordinary Prize of Doctor in M edicine (Spain). Actual Position • General Director & Chairman of the R&D and innovation Dpt., BIOAVEDA, S.L., Jaén, Spain; • Invited Professor of Immunology to several Spanish & SouthAmerican Universities. Professional background • Research fields: Inmunopathology of skin cancer (melanoma) & hepatic carcinoma; Links between innate and adaptive immunity; Inmunology of childhood and elderly; Immunity, infection, cancer & vaccines. • R&D of Immunomodulators (AM 3, EPL [Polypodium leucotomos extract], VRCTC310 [secreted Phospolipase A2]). 1 • R&D+i on products from Healthy Plants: Extra Virgin Olive Oil (oHo ) and others, in the fields of: o nutrition/inflammation o prevention and treatment of cancer, infections and metabolic illnesses with cardiovascular repercussion o sun protection. Merits & Honours Prize “Anticancer Research” (Greece); Prize Carlos M anero Pineda to Tumor Immunology (Spain); President of the “1st. Symp on AIDS related neoplasias”, Toledo (Spain); Chairman Int Symp on AIDS-related Neoplasias; Chairman World Congress on Inflammation: Italiy, Swizertland; Chairman Int Congr on Vitiligo, Siria; Invited Lecturer Int Cong on “Inmunology of the Elderly (ImAginE)”. Córdoba, (Spain); Prize to the best publication in Rev Esp de Geriatría y Gerontología. 2001; Honour M ember of the Andalucía Committe for Ecologic A griculture. S ome Publications: - Villarrubia VG, et al. New vaccines and the immune response. I. The immunologic memory. Humoral vs cellular response. M ed Clin (Barc) 1996; 107:146-54. - Villarrubia VG, et al. New vaccines and the immune response. II. The environment of the antigen presentation. Adjuvants as inducers of T-cell responses. M ed Clin (Barc) 1996; 107:185-96. - Villarrubia VG, et al. Immune alterations provoked by ultraviolet radiation. Its pathogenic relationship with photoaging and skin cancer (Spanish). Piel 1996; 11:46270. - Villarrubia VG, et al. The immunosenescent phenotype in mice and humans can be defined by alterations in the natural immunity. Reversal by immunomodulation with oral AM 3. Immunopharmacol & Immunotoxicol 1997;19:53-74. - Rayward J, Villarrubia VG, et al. An extract of the fern Polypodium leucotomos inhibits human peripheral blood mononuclear cells proliferation in vitro. Int J Immunopharmacol 1997; 19: 9-14. - Villarrubia VG. Inmunology of malignant melanoma (spanish). Dermatol & Cosmet 1996; 6: 49-53. 2 - González S , Pathak MA, Cuevas J, Villarrubia VG, Fitzpatrick TB. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatol Photoimmunol Photomed 1997; 13:50-60. - Costa LA, et al, and Villarrubia VG. Tumor regression of advanced carcinomas following intra-and/or peri-tumoral inoculation with VRCTC 310: preliminary report of two cases. Immunopharmacol & Immunotoxicol 1998; 20:15-25. - Costa LA, Miles H, Araujo CE, Villarrubia VG. A pilot comparative study withVRCTC-310 for the treatment of haevely pretreated advanced cancer patients. 17th Int Cancer Congress UICC 1998; 149:1-4. - Villarrubia VG, et al. Immune/inflammatory pathogeny of asthma. Therapeutic implications (Spanish). Allergol et Immunopathol 1999; 27:213-31. - Villarrubia VG, et al. Immunopathogeny of elderly: the deterioration of inat e immunity and its effects on specific immunity (spanish). Rev Esp Geriatr Gerontol 2000; 35:30-42. - Córdova A, Villarrubia VG, Prieto A, Alvarez-Mon M. AM 3 shows antiinflammatory activities in elite sportsmen. En: Proc 5th World Congress on Trauma, Shock, Inflammation and Sepsis. Edit. Eugen Faist. M onduzzi edit. Bologna, Italy 2000; pp: 295-9. - Gonzalez S , et al, and Villarrubia VG. An extract of the fern Polypodium leucotomos modulates Th1/Th2 cytokines balance in vitro and appears to exhibit antangiogenic activities in vivo: pathogenic relationships and therapeutic implications. Anticancer Res 2000; 20:1567-76. - Prieto A, Reyes E, Bernstein ED, Martínez B, Montserrat J, Izquierdo JL, Callol L, de Lucas P, Alvárez-S ala R, Alvárez-S ala JL, Villarrubia VG, Alvárez-Mon M. Defective natural killer and phagocytic activities in chronic obstructive pulmonary disease are restored by glicophosphopeptical (Inmunoferón). Am J Respir Crit Care M ed 2001; 163:1578-83. - Villarrubia VG, et al. Epidemiology and immunopathogeny of non-melanoma skin cancer. The initiating and promoting role of HPV (Spanish). Piel 2001; 16:428-38. - Villarrubia VG, et al. Human Papiloma Virus and ultraviolet radiation: “ les liasons dangereuses” for the skin (spanish). Piel 2001; 16:494-505. 3 - Villegas FR, Coca S , Villarrubia VG, et al. Prognostic significance of tumor infiltrating natural killer cells in patients with squamous cell lung cancer. Lung Cancer 2002; 35:23-8. - Perez-García R, Perez-Garcia A, Verbeleen D, Bernstein ED, Villarrubia VG, Alvarez-Mon M. AM 3 (Inmunoferon) as an adjuvant to hepatitis B vaccination in hemodialysis patients. Kidney Int 2002; 61:1845-52. - Villarrubia VG, Costa L, Díez R. Secreted A2 phospholipases (sPLA2) Friends or foes? Actors of the bacteria and the anti-HIV resistance? M ed Clin 2004; 123:749-57. - Reyes E, Jaén P, Heras ED, Eusebio ED, Carrión F, Cuevas J, González S , Villarrubia VG, et al. Systemic immunomodulatory effects of Polypodium leucotomos as an adjuvant to PUVA therapy in generalized vitiligo: A pilot study. Journal Dermatology Sciences 2006 Jan 16; [Epub ahead of print]. - Villarrubia VG. Health impact of maternal breastfeeding. Influence of extra virgin olive oil. (spanish). In: http://www.bioaveda.com/salud.html - Villarrubia VG, Gonzalez P, Torres Morales J. Oilenes* and pesticides: A furtive attack to the olive oil-related health? Implications in cancer. Asthma and the immunologic hygiene hypothesis (Spanish). In: http://www.bioaveda.com/salud.html Correspondence: Dr. Vicente G. Villarrubia Director Dpt. I+D+i BIOAVEDA, S.L C/ Sauce 28 Urb. Azahar 23006-Jaén (España) E-mail: [email protected] web: www.bioaveda.com 4