Download Chocolate coats in Pomeranians

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project

Document related concepts

Biology and consumer behaviour wikipedia , lookup

Epigenetics of human development wikipedia , lookup

Gene therapy of the human retina wikipedia , lookup

Saethre–Chotzen syndrome wikipedia , lookup

Genetic engineering wikipedia , lookup

RNA-Seq wikipedia , lookup

Point mutation wikipedia , lookup

Vectors in gene therapy wikipedia , lookup

Genome evolution wikipedia , lookup

History of genetic engineering wikipedia , lookup

Gene therapy wikipedia , lookup

Copy-number variation wikipedia , lookup

Nutriepigenomics wikipedia , lookup

Gene desert wikipedia , lookup

Gene wikipedia , lookup

Gene nomenclature wikipedia , lookup

Helitron (biology) wikipedia , lookup

Therapeutic gene modulation wikipedia , lookup

Gene expression programming wikipedia , lookup

Genome (book) wikipedia , lookup

Site-specific recombinase technology wikipedia , lookup

Gene expression profiling wikipedia , lookup

Artificial gene synthesis wikipedia , lookup

Microevolution wikipedia , lookup

Designer baby wikipedia , lookup

Transcript
Chocolate coats in Pomeranians:
Many people think of chocolate as a ‘dilution’ gene and therefore equate problems such as CDA –
‘Colour Dilution Alopecia’, and general fading to the chocolate gene. Dilution isn’t an accurate
explanation of the chocolate gene.
A chocolate coat is the result of a dog carrying two copies of the ‘B’ gene recessive – (b/b). Black and
chocolate are eumelanin and while eumelanin is being made it is first chocolate and then a reaction
occurs to make it black. In the ‘b’ defect, the last step doesn’t occur so instead of becoming black the
eumelanin stays chocolate coloured. So rather than diluting colour, the process is actually an
incomplete transfer of pigment resulting in a chocolate coat. If full pigment was transferred the coat
would be black. This is very different than dilution. A (B/b) dog is black but carries chocolate. Carrying
one copy of ‘b’ does not dilute or wash out a black nose and/or coat. A dog who is (B/B) is no more black
than a (B/b) dog. Only one copy of the pair is expressed. The other is hidden but can be passed to
offspring.
The “D” gene is the dilution gene which brings a black coat down to blue and a Chocolate coat to
Beaver/Isabella/Lavender (the actual colour names differ among the breeds and the breeders). In blue,
the black pigment is made but doesn’t get transferred properly to the nose and hair. The same is true
for Beaver/Isabella/Lavender as the chocolate pigment is made but it doesn’t get transferred properly to
the nose and hair. It sort of clogs up the pigment-producing cells and causes problems.
Page 1 of 2
© 2013 R. Rose, TinyBear Pomeranians
www.tinybearpoms.com
Independent of colour and pattern genes, which also affect the coat’s phenotype, are genes that
‘intensify colour’ and ‘modify pattern size’. There is no test to identify these genes at this point.
There are different types of the ‘B’ recessive gene. Per Dr. Sheila Schmutz, there are actually 3 common
mutations (bS,bd, bc) and perhaps additional rare ones that occur in this gene which result in various
shades of brown instead of black eumelanin production. Most of the DNA testing companies simply
report all the alleles as ‘b’.
So not all Chocolate is the same therefore breeding chocolate to chocolate can result in varying shades.
There are no known health concerns or defects associated with chocolate to chocolate breeding. What
may happen is too close inbreeding resulting in genetic defects because of the limited number of
chocolate dogs available for breeding, in some breeds.
So an exact shade or intensity of chocolate is dependent on multiple genes. Finding the right dogs to
bring about your preferred intensity is the job and that could come from other coloured dogs who carry
one copy of the ‘B’ recessive – (b), or it could just as easily come from another chocolate dog.
Until every gene in a dog can be identified by testing, we will have to continue test breedings and some
‘coin flipping’ in an attempt to get exactly what we
Page 2 of 2
© 2013 R. Rose, TinyBear Pomeranians
www.tinybearpoms.com