* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Albert Libchaber Detlev W. Bronk Professor The Rockefeller
Epigenetics of human development wikipedia , lookup
Deoxyribozyme wikipedia , lookup
Gene therapy of the human retina wikipedia , lookup
Nicotinic acid adenine dinucleotide phosphate wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Nucleic acid tertiary structure wikipedia , lookup
Nucleic acid analogue wikipedia , lookup
RNA silencing wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Primary transcript wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Transfer RNA wikipedia , lookup
Point mutation wikipedia , lookup
History of RNA biology wikipedia , lookup
Epitranscriptome wikipedia , lookup
Non-coding RNA wikipedia , lookup
Mir-92 microRNA precursor family wikipedia , lookup
Albert Libchaber Detlev W. Bronk Professor The Rockefeller University “Physical Aspects of the Origin of Life Problem” Abstract: In the fascinating puzzle of the origin of life, two main phenomena distinguish biology from non-equilibrium thermodynamic processes: the presence of a code and the ability of machines to self-reproduce. - In the RNA world of the early soup we are studying how a genetic code could originate, building an RNA ribozyme that can charge an amino acid without enzymes, a primitive tRNA. We also show that the initial code could have started with four amino acids only: valine (GUC), alanine (GCC), glycine (GGC), aspartate (GAC). - Encapsulation of cells in a membrane is another step in this puzzle. Building an artificial cell based on gene expression inside vesicles reveal the physical constraints to overcome: energy exchange, osmotic pressure, sources and sinks for protein production. This cell can sustain protein production for about one week. Self-reproduction will be the next step.