Download Tranquility™ Formula

TECHNICAL DATA SHEET
G! Tranquility™ Formula
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Life in the 21st century is stressful. We are constantly dealing with situations
that result in stress, anxiety and a general feeling of unsettledness. Fear and
anxiety go hand in hand. Disabling physical, emotional and mental symptoms
rate of prescriptions written for anti-anxiety drugs has more than doubled in
the past decade. Anti-anxiety medications, anti-depressants and tranquilizers
account for one fourth of all prescriptions written in the U.S. each year.
Tranquility™ formula contains key ingredients that restores and optimizes
neurotransmitter function. Phenibut (4-amino-3-phenylbutyric acid) is a
derivative of the neurotransmitter GABA and crosses the blood-brain barrier.
Taurine acts as an inhibitory neurotransmitter and closely resembles the
structure and metabolism of the other inhibitory neurotransmitters, GABA
and glycine. Correcting the cause of the problem, neurotransmitter dysfunction,
helps restore the delicate brain chemistry balance. Additionally, we added B6,
B12 and folinic acid to supply essential nutrients that help improve and stabilize
serotonin levels and neurotransmission.
S u p p l e m e n t
Serving size: 1 capsule
F a c t s
Phenibut (4-amino-3-phenylbutyric acid)
Servings per container: 90
Amount per serving
Vitamin B6 (as Pyridoxine HCl)
Vitamin B6 (as Pyridoxal-5-Phosphate)
Vitamin B12 (as Methylcobalamin)
%DV
2 mg
100%
0.5 mg
25%
3846%
Folinic Acid (5-formyl tetrahydrofolate)
100 mcg
100 mcg
Phenibut (4-amino-3-phenylbutyric acid)
264 mg
*
L-Taurine (free form)
211 mg
*
Percent Daily Values are based on a 2,000 calorie diet.
* Daily Value not established.
Other ingredients: Vegetarian capsules
INGREDIENTS:
25%
clinically since the 1960’s for anxiety, sleep disorders, posttraumatic stress disorders, stuttering and the treatment of
other neuroses. The addition of the phenyl ring to GABA
allows the compound to more easily cross the blood-brain
agonist at GABA (B) receptors, although it does have some
established role of GABA (B) receptors is inhibition of the
release of some neurotransmitters, and it may also serve as
a negative feedback mechanism for GABA release (3).
Phenibut also increases dopamine levels, and has been
postulated that the structural similarity to beta-
that include neuroprotection by increasing resistance to the
production in the brain (5). Phenibut also protects
dopaminergic neurons, and improved the condition of patients
being treated with anti-parkinsonic drugs (6).
L-Taurine
Taurine is a conditionally essential amino sulfonic acid present
cannot maintain adequate levels of taurine and supplementa-
These statements have not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure or prevent any disease.
tion becomes necessary (7).Taurine is important in metabolism,
especially in the brain. It is essential for newborns, as they cannot
yet make it. Adults can produce taurine from cysteine with the
additional help of pyridoxine (B6). Taurine functions in electrically
active tissues such as the brain and heart and stabilizes cell
membranes. Taurine is an inhibitory neurotransmitter, and its
main use has been to help treat epilepsy and other excitable
brain states (8). Neurotransmitter transport systems have a
common structure of 12 presumed transmembrane helices and
include carriers for GABA, noradrenaline/adrenaline, dopamine,
serotonin, proline, glycine, betaine and taurine.
longer and the majority is converted to the active coenzyme.
In this form, folinic acid can be directly uptaken by the bloodbrain barrier that ordinarily remains impermeable to dietary
treating mental disorders (12).
Vitamin B6 (Pyridoxine/ Pyridoxal-5-Phosphate)
Pyridoxine is required for amino acid metabolism. In the body,
pyridoxine is converted to coenzymes pyridoxal phosphate
and pyridoxamine phosphate, in a wide variety of metabolic
reactions. These reactions include transamination of amino
acids, conversion of tryptophan to niacin, synthesis of GABA
in the central nervous system, metabolism of serotonin,
norepinephrine and dopamine, metabolism of polyunsaturated
fatty acids and phospholipids, and the synthesis of the heme
group of hemoglobin (9). We use both forms of B6 to insure
absorption is achieved, as a number of people cannot convert
pyridoxine into the biologically active form of pyridoxal-5phosphate.
Vitamin B12 (Methylcobalamin)
Methylcobalamin is the biologically active form of B12. Vitamin
B12 is a naturally occurring B complex vitamin that is formed
by microorganisms. Research indicates that low levels of B12
contribute to poor mood and feelings related to anxiety and
depression. Levels of neurotransmitters in the brain of B12
controls (10).
Folinic Acid (5-formyl tetrahydrofolate)
Folinic acid also known as 5-formyl tetrahydofolate, is one
active form in a group of vitamins known as folates. In the
body folinic acid may be converted into any of the other
active forms of folate. Folinic acid raises the tetrahydrobiopterin
(BH4) levels, which is a critical cofactor for the manufacture of
all mood-regulating neurotransmitters (11). Unlike regular
folic acid supplements following an oral dose, up to 92% of
folinic acid is absorbed from the gut. It remains in the body
Patients: Consult with your healthcare professional
for the proper dosage and use of this formula.
For more information about this and other Condition
Specific Formulas® please visit our website at:
www.mpn8.com
Portland, OR 97225
REFERENCES:
1. CNS Drug Rev. 2001 Winter;7(4):471-61
2. Pavlov J Biol Sci. 1986 Oct-Dec;21(4):129-40
3. Am J Physiol Gastrointest Liver Physiol. 2001Aug;281(2):G311-5
4. Pharmacol Toxicol. 1990 Jan;66(1) 41-4
5. Eksp Klin Farmakol.1994 Mar-Apr;57(2):13-6
6. Zh Nevropatol Psikhiatr Im S S Korsakova.1986;86(8):1146-8
7. Ann Med 1999;31:318-2
8. Adv Pediatr 1985;32:1-42
9. McKevoy GK, ed AHFS Drug information Bethesda,MD:1998
10. Int J Vitam Nutr Res. 1977;47(2):119-2
11. Godfrey PS Toone BK, Carney NW et al. Lancet 1990;336:392-395
12. Folates: Supplemental Forms and Therapeutic Applications by Gregory S. Kelly ND