Download Activated B Complex

Activated B Complex
B Vitamins in Activated Forms
A comprehensive B-complex formula providing active
forms of B vitamins for optimal utilization.
Offering Pyridoxal-5-Phosphate, Riboflavin 5-Phosphate and Folinic
Acid, as well as Inositol, Choline and the remaining B vitamins,
Pure Innovation Activated B Complex is designed to help support
overall well-being, especially during times of stress when nutrient
need may be increased.
Indications:
For practitioner dispensing only
Aids, assists or helps in
the maintenance of general well-being
of stress
Beneficial during times
Source of vitamin B12. Can assist in maintaining
normal blood. Blood tonic
For the symptomatic relief of pre-
menstrual tension/syndrome
Relief of menstrual symptoms
May help to support normal, healthy homocysteine levels
Pack Size: 60 capsules
Recommended Dose:
Take one capsule daily with
food, or as directed by your
healthcare practitioner.
in healthy individuals
health
May help to support cardiovascular
May help to support cognitive function
support the brain and nervous system
May help to
May help to support
methylation pathways
Excipients:
Glycine, leucine, colloidal anhydrous silica, vegetable capsule
Warnings:
If symptoms persist, consult your healthcare practitioner.
Each capsule contains:
Thiamine hydrochloride
equiv. Thiamine
50mg
40mg
Riboflavin 5-Phosphate
20mg
Nicotinamide
80mg
Nicotinic acid
20mg
Pyridoxal-5-Phosphate
equiv. Pyridoxine
Pyridoxine hydrochloride
equiv. Pyridoxine
Calcium Pantothenate
equiv. Pantothenic Acid
Innovative Research
Purest Ingredients
10mg
Choline bitartrate
100mg
6.8mg
Inositol
100mg
20mg
Biotin
500μg
16.5mg
Cyanocobalamin
500μg
164mg
Calcium Folinate
500μg
150mg
equiv. Folinic Acid
Optimised Absorption
Nutritional supplements should not replace a balanced diet
This information is for healthcare professionals only
Call 1800 625 934 / visit www.bioconcepts.com.au
384μg
Hypoallergenic
Technical Information
Biologically active forms of vitamin B6 (Pyridoxal-5-Phosphate),
Folic Acid (Folinic Acid) and vitamin B2 (Riboflavin 5-Phosphate),
can bypass the enzymatic processes in the body that lead to
the active nutrient forms, and may therefore produce more
significant results. Research has identified genetic differences in
the activity of certain biologic enzymes, with some individuals
exhibiting the potential inability to endogenously activate, and
therefore utilize, non-active forms of B vitamins.
Folinic Acid bypasses the deconjugation and reduction steps
required for Folic Acid use in the body. Folinic Acid has been
deemed to be a more metabolically active form of Folate, and is
capable of boosting levels of the coenzyme forms of the vitamin
in circumstances where Folic Acid has little to no effect. It has
been suggested that Folinic Acid is more readily transported
through the blood-brain-barrier into the central nervous system,
and has a longer half life in the body than Folic Acid.
The active form of vitamin B6 – Pyridoxal-5-Phosphate – is a
cofactor for the activity of a number of enzymes involved in
metabolism. Riboflavin 5-Phosphate is the active form of vitamin
B2, which is an essential component of the electron transport
chain, energy production and metabolism in the body.
Fats/lipids
Fatty acids
outer mitochondrial
membrane
Carbohydrates
3 Carbon Pyruvate
Protein
Amino acids
B3, B2, Biotin
B5
inner mitochondrial
membrane
Citrate
Oxaloacetate
B3
The Citric
Acid Cycle
L-Malate
Isocitrate
B3
d-Ketoglutarate
B1, B2, B3, B5
Fumarate
B2
Succinate
Succinyl CoA
Beneficial During Times of Stress
During periods of intense stress, there is an increased requirement
for the water-soluble B vitamins. This demand may be intensified
by reduced digestive function and absorption, due to reduced
parasympathetic nervous system activity. B vitamins support
the body’s response to stress by supporting the respective body
systems and overall nutrient status. Research has identified
genetic differences in the activity of certain enzymes, with
some individuals exhibiting the potential inability to intrinsically
activate and utilize non-active forms of B vitamins.(16)
Aids, Assists or Helps in the Maintenance of General
Well-Being
As exercise, illness and stress tax metabolic pathways that depend
on B vitamins, such as Thiamine, Riboflavin and Pyridoxine, the
requirements for these vitamins may be increased in stressed,
active, or recovering individuals.(1)
When viewing the Citric Acid Cycle (Figure 1), it is evident how
vital the B group vitamins are as cofactors for the function of
this pathway. If the body is deficient in any of these integral
nutrients due to poor supply, reduced absorption or increased
demand, it is clear how energy production and well-being may
be compromised.
Thiamine serves as a cofactor for several enzymes involved in
carbohydrate catabolism, including pyruvate dehydrogenase,
transketolase, alpha-ketoglutarate, as well as amino acid
catabolism.(7)
Two fundamental co-enzymes of the Citric Acid Cycle – flavinadenine dinucleotide (FAD) and flavin mononucleotide (FMN)
(Riboflavin 5-Phosphate) – are both important for the body’s
production of adenosine triphosphate and rely upon vitamin B2
as a cofactor.(8) The activated form of B2 bypasses a biochemical
step and may offer more efficient support of energy production.
Niacin is involved in numerous biological functions and
is a precursor for the coenzymes nicotinamide adenine
dinucleotide (NAD+) and nicotinamide adenine dinucleotide
hydrogen (NADH), which are involved in a number of metabolic
functions.(9)
Vitamin B5 (Pantothenic Acid) is required for coenzyme A
synthesis – an important component of energy storage and
release. In conjunction with Thiamine, Riboflavin and Niacin,
vitamin B5 is involved in the oxidative decarboxylation of
pyruvate and alpha-ketoglutarate in the Citric Acid Cycle.(8)
References available on request
This information is for healthcare professionals only
Call 1800 625 934 / visit www.bioconcepts.com.au
5320911
Figure 1: The Citric Acid Cycle