Download 1 riboflavin (rye-boe-flay-vin) - DavisPlus

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Interactions
Drug-Drug: Phenothiazines, tricyclic antidepressants, probenecid, and
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riboflavin (rye-boe-flay-vin)
chronic ingestion of alcohol increase riboflavin requirements.
vitamin B2
Classification
Therapeutic: vitamins
Pharmacologic: water soluble vitamins
Pregnancy Category A
Route/Dosage
Indications
● Assess patient for signs of vitamin B2 deficiency (dermatoses, stomatitis, ocular in-
Treatment of Deficiency
PO (Adults): 5– 10 mg/day.
NURSING IMPLICATIONS
Assessment
Treatment and prevention of riboflavin deficiency, which may be associated with
poor nutritional status or chronic debilitating illnesses.
Action
Active metabolites serve as coenzymes for metabolic reactions involving transfer of
hydrogen ions, including tissue respiration. Necessary for normal RBC function.
Therapeutic Effects: Replacement in or prevention of deficiency.
Pharmacokinetics
Absorption: Well absorbed from the upper GI tract by an active transport process.
Distribution: Widely distributed. Crosses the placenta and enters breast milk.
Metabolism and Excretion: Converted to flavin mononucleotide (FMN) and
flavin adenine dinucleotide (FAD), which are the active coenzymes. Amounts in excess of requirements are excreted unchanged by the kidneys.
Half-life: 66– 84 min.
TIME/ACTION PROFILE
ROUTE
ONSET
PEAK
DURATION
PO
unknown
unknown
unknown
Contraindications/Precautions
Contraindicated in: No known contraindications.
Use Cautiously in: No known precautions.
Adverse Reactions/Side Effects
GU: yellow discoloration of urine (large doses only).
⫽ Canadian drug name.
⫽ Genetic Implication.
flammation and irritation, photophobia, and cheilosis) prior to and periodically
throughout therapy.
● Lab Test Considerations: May cause false elevations in urobilinogen and urinary catecholamine measurements.
Potential Nursing Diagnoses
Imbalanced nutrition: less than body requirements (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)
Implementation
● Because of infrequency of single B-vitamin deficiencies, combinations are com-
monly administered.
Patient/Family Teaching
● Instruct patient to take as directed. If a dose is missed, it may be omitted, because
an extended period of time is required to become deficient in riboflavin.
● Encourage patient to comply with diet recommendations of health care profes-
sional. Explain that the best source of vitamins is a well-balanced diet with foods
from the four basic food groups. Foods high in riboflavin include dairy products;
enriched flour; nuts; meats; fish; and green, leafy vegetables; little is lost during
cooking.
● Patients self-medicating with vitamin supplements should be cautioned not to exceed RDA. The effectiveness of megadoses for treatment of various medical conditions is unproved and may cause side effects.
● Advise patient to avoid alcoholic beverages; alcohol impairs the absorption of riboflavin.
CAPITALS indicate life-threatening, underlines indicate most frequent.
Strikethrough ⫽ Discontinued.
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● Explain to patient that a medically insignificant increase in yellow coloration of
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urine may occur.
● Emphasize the importance of follow-up exams to evaluate progress.
Evaluation/Desired Outcomes
● Prevention of or decrease in the symptoms of riboflavin deficiency.
Why was this drug prescribed for your patient?
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