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Essentials of Human Anatomy & Physiology
Elaine N. Marieb
Seventh Edition
Chapter 9
The Nervous System
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Functions of the Nervous System
• Maintain homeostasis with electrical signals
• Provide for sensation
• Provide for higher mental functions and
emotions
• Activate muscles and glands
Roles of the Nervous System
1. Sensory input – gathering information
 To monitor changes occurring inside and
outside the body (changes = stimuli)
2. Integration –
 to process and interpret sensory input
and decide if action is needed.
3. Motor output
 A response to integrated stimuli
 The response activates muscles or glands
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Slide 7.1a
Structural Classification of the
Nervous System
 Central nervous system (CNS)
 Brain & spinal cord
 Dorsal cavity
 Command center
 Takes in info & give instruction
 Peripheral nervous system (PNS)
 Nerves outside the brain and spinal cord
 Communication lines
Slide 7.2
Functional Classification of the
Peripheral Nervous System
 Sensory (afferent) division
 Nerve fibers that carry information to the
central nervous system
Figure 7.1
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Slide 7.3a
Functional Classification of the
Peripheral Nervous System
 Motor (efferent) division
 Nerve fibers that carry impulses away from
the central nervous system
Figure 7.1
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Slide 7.3b
Functional Classification of the
Peripheral Nervous System
 Motor (efferent) division
 Two subdivisions
 Somatic nervous system = voluntary
 Autonomic nervous system = involuntary
Figure 7.1
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Slide 7.3c
Organization of the Nervous
System
Figure 7.2
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Slide 7.4
Neuroglia vs. Neurons
•
•
•
•
Neuroglia divide.
Neurons do not.
Most brain tumors are “gliomas.”
Most brain tumors involve the neuroglia
cells, not the neurons.
• Consider the role of cell division in
cancer!
Support Cells of the PNS
 Schwann cells
 Form myelin sheath in the peripheral
nervous system
Figure 7.3e
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Slide 7.7b
Nervous Tissue: Neurons
 Neurons = nerve cells
 Cells specialized to transmit messages
 Major regions of neurons
 Cell body – nucleus and metabolic center
of the cell
 Processes – fibers that extend from the
cell body (dendrites and axons)
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Slide 7.8
Neuron Anatomy
 Cell body
 Nucleus
 Large
nucleolus
Figure 7.4a
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Slide 7.9b
Neuron Anatomy
 Extensions
outside the cell
body
 Dendrites –
conduct
impulses toward
the cell body
 Axons – conduct
impulses away
from the cell
body (only 1!)
Figure 7.4a
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Slide 7.10
Axons and Nerve Impulses
 Axons end in axonal terminals
 Axonal terminals contain vesicles with
neurotransmitters
 Axonal terminals are separated from the
next neuron by a gap
 Synaptic cleft – gap between adjacent
neurons
 Synapse – junction between nerves
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Slide 7.11
Nerve Fiber Coverings
 Schwann cells –
produce myelin
sheaths in jelly-roll
like fashion
 Nodes of Ranvier –
gaps in myelin
sheath along the
axon
Figure 7.5
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Slide 7.12
Application
• In Multiple Scleroses the myelin sheath is
destroyed.
• The myelin sheath hardens to a tissue called
the scleroses.
• This is considered an autoimmune disease.
• Why does MS appear to affect the muscles?
Neuron Cell Body Location
 Most are found in the central nervous
system
 Gray matter – cell bodies and unmylenated
fibers
 Nuclei – clusters of cell bodies within the
white matter of the central nervous system
 Ganglia – collections of cell bodies
outside the central nervous system
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Slide 7.13
Classification of Neurons (based
on fxn.
 Sensory (afferent) neurons
 Carry impulses from the sensory receptors
Motor (efferent) neurons
 Carry impulses from the central nervous
system to muscles and glands
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Slide
Functional Classification of
Neurons
 Interneurons (association neurons)
 Found in neural pathways in the central
nervous system
 Connect sensory and motor neurons
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Slide
Neuron Classification
Figure 7.6
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Slide 7.15
How Neurons Function
(Physiology)
 Irritability – ability to respond to stimuli
 Conductivity – ability to transmit an
impulse
 The plasma membrane at rest is
polarized
 Fewer positive ions are inside the cell than
outside the cell
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Slide 7.17
Starting a Nerve Impulse
 Depolarization – a
stimulus depolarizes the
neuron’s membrane
 A depolarized
membrane allows
sodium (Na+) to flow
inside the membrane
 The exchange of ions
initiates an action
potential in the neuron
Figure 7.9a–c
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Slide 7.18
The Action Potential
 If the action potential (nerve impulse)
starts, it is propagated over the entire
axon
 Potassium ions rush out of the neuron
after sodium ions rush in, which
repolarizes the membrane
 The sodium-potassium pump restores
the original configuration
 This action requires ATP
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Slide 7.19
Nerve Impulse Propagation
 The impulse
continues to move
toward the cell body
 Impulses travel
faster when fibers
have a myelin
sheath
Figure 7.9c–e
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Slide 7.20
All-or-None Response
• Greater intensity of the stimulation does not
produce a stronger impulse but rather more
impulses are sent
• Remember this from the muscular system??
Continuation of the Nerve Impulse
btwn. Neurons (Conductivity)
 Impulses are able to cross the synapse
to another nerve (electrochemical
event)
 Neurotransmitter is released from a nerve’s
axon terminal
 The dendrite of the next neuron has
receptors that are stimulated by the
neurotransmitter
 An action potential is started in the dendrite
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Slide 7.21
How Neurons Communicate at
Synapses
Figure 7.10
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Slide 7.22
Ways to slow conduction
•
•
•
•
•
Alcohol
Sedatives
Anesthetics
Cold
Continuous pressure
The Reflex Arc
 Reflex – rapid, predictable, and
involuntary responses to stimuli
 Reflex arc – direct route from a sensory
neuron, to an interneuron, to an effector
Figure 7.11a
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Slide 7.23
Simple Reflex Arc
Figure 7.11b, c
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Slide 7.24
• The knee-jerk reflex is an example of a 2neuron reflex arc (sensory receptor, afferent
neuron, efferent neuron, efferent organ)
• What would be the componeets of a 3neuron reflex arc?
Types of Reflexes and Regulation
 Autonomic reflexes
Smooth muscle regulation
Heart and blood pressure regulation
Regulation of glands
Digestive system regulation
 Somatic reflexes
Activation of skeletal muscles
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Slide 7.25
Central Nervous System (CNS)
 CNS develops from the embryonic
neural tube
 The neural tube becomes the brain and
spinal cord
 The opening of the neural tube becomes
the ventricles
 Four chambers within the brain
 Filled with cerebrospinal fluid
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Slide 7.26
Regions of the Brain
 Cerebral
hemispheres
 Diencephalon
 Brain stem
 Cerebellum
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Figure 7.12
Slide 7.27
Cerebral Hemispheres (Cerebrum)
 Paired (lf & rt)
superior parts of
the brain=
hemispheres
 Include more
than half of the
brain mass
 Largest & most
complex area of
the brain
Figure 7.13a
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Slide
Cerebral Hemispheres (Cerebrum)
 The surface
is made of
ridges (gyri)
and grooves
(sulci)
Figure 7.13a
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Slide
Lobes of the Cerebrum
 Fissures (deep grooves) divide the
cerebrum into lobes
 Longitudinal fissure – separates
hemispheres
 Lobes of the cerebrum
 Frontal lobe
 Parietal lobe
 Occipital lobe
 Temporal lobe
Slide
Lobes of the Cerebrum
Figure 7.15a
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Slide
Lobes of the brain
 Frontal Lobe
Primary motor area – sends impulses
to skeletal muscles
Broca’s area – involved in our ability
to speak
Intellectual and psychic functions
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Slide 7.30
Sensory and Motor Areas of the
Cerebral Cortex
Figure 7.14
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Slide 7.31
 Temporal Lobe
 Gustatory, auditory, olfactory area
 Occipital Lobe
 Visual areas
 Parietal Lobe
 Sensations; pain; hot & cold; touch; speech
& reading
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Slide
Specialized Area of the Cerebrum
 Interpretation areas of the cerebrum
 Speech/language region
 Language comprehension region
 General interpretation area
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Slide
Specialized Area of the Cerebrum
Figure 7.13c
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Slide
Layers of the Cerebrum
 Gray matter
 Outer layer
 Composed
mostly of neuron
cell bodies
 Initiates
thoughts &
voluntary actions
Figure 7.13a
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Slide
Layers of the Cerebrum
 White matter
 Fiber tracts
inside the gray
matter
 Example:
corpus callosum
connects
hemispheres
Figure 7.13a
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Slide
Diencephalon
 Sits on top of the brain stem
 Enclosed by the cerebral heispheres
 Made of three parts
 Thalamus
 Hypothalamus
 Epithalamus
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Slide
Thalamus
 The relay station for sensory impulses
 Transfers impulses to the correct part of
the cortex for localization and
interpretation
 Ability to concentrate
 Degree of wakefulness
 Pleasantness & unpleasantness
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Slide 7.35
Hypothalamus
 Helps regulate body temperature
 Controls water balance
 Regulates metabolism
 Appetite and thirst
 An important part of the limbic system
(emotions)
 The pituitary gland is attached to the
hypothalamus
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Slide
Epithalamus
 Houses the pineal body (an endocrine
gland) – sexual maturity and growth
 Includes the choroid plexus – forms
cerebrospinal fluid
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Slide 7.37
Brain Stem
 Attaches to the spinal cord
 Parts of the brain stem
 Midbrain
 Pons
 Medulla oblongata
 Size your thumb (~ 3 inches)
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Slide
Midbrain
 Mostly composed of tracts of nerve
fibers
 Reflex centers for vision and hearing
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Slide 7.39
Pons
 The bulging center part of the brain
stem
 Mostly composed of fiber tracts
 Includes nuclei involved in the control of
breathing
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Slide 7.40
Medulla Oblongata
 The lowest part of the brain stem
 Merges into the spinal cord
 Contains important control centers
 Heart rate control
 Blood pressure regulation
 Breathing
 Swallowing
 Vomiting
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Slide 7.41
Cerebellum
 Two hemispheres with convoluted
surfaces
 Functions in balance and coordination
 Provides involuntary coordination of
body movements
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Slide
Cerebellum
Figure 7.15a
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Slide
Protection of the Central Nervous
System
 Scalp and skin
 Skull and vertebral column
 Meninges
Figure 7.16a
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Slide
Protection of the Central Nervous
System
 Cerebrospinal fluid
 Blood brain barrier
Figure 7.16a
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Slide
Meninges
 Dura mater
 Double-layered external covering
 Periosteum – attached to surface of the
skull
 Meningeal layer – outer covering of the
brain
Folds inward in several areas
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Slide
Meninges
 Arachnoid layer
 Middle layer
 Web-like
 Pia mater
 Internal layer
 Clings to the surface of the brain
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Slide
Cerebrospinal Fluid
 Similar to blood plasma composition
 Forms a watery cushion to protect the
brain
 Circulated in arachnoid space,
ventricles, and central canal of the
spinal cord
 Changes in composition help diagnose
disorders
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Slide 7.46
Nervous System disorders
• Meningitis – inflammation of the meninges;
serious threat to the brain b/c of bacterial or
viral types may spread into central nervous
tissue
• Encephalitis – inflammation of the brain
• Hydrocephalus – “water on the brain;” CSF
cannot drain and pressure is exerted on the
brain
Blood Brain Barrier
 Includes the least permeable capillaries
of the body
 Excludes many potentially harmful
substances
 Useless against some substances
 Fats and fat soluble molecules
 Respiratory gases
 Alcohol
 Nicotine
 Anesthesia
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Slide 7.48
Traumatic Brain Injuries (TBI)
 Concussion
 Slight or mild brain injury
 Bleeding & tearing of nerve fibers happened
 Recovery likely with some memory loss
 Contusion
 A more severe TBI
 Nervous tissue destruction occurs
 Nervous tissue does not regenerate
 Cerebral edema
 Swelling from the inflammatory response
 May compress and kill brain tissue
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Slide 7.49
Cerebrovascular Accident (CVA)
 Commonly called a stroke
 The result of a ruptured blood vessel
supplying a region of the brain
 Brain tissue supplied with oxygen from
that blood source dies
 Loss of some functions or death may
result
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Slide 7.50
Alzheimer’s Disease
 Progressive degenerative brain disease
 Mostly seen in the elderly, but may
begin in middle age
 Structural changes in the brain include
abnormal protein deposits and twisted
fibers within neurons
 Victims experience memory loss,
irritability, confusion and ultimately,
hallucinations and death
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Slide 7.51
Spinal Cord
 Extends from medulla
oblongata to T12 region
 31 pairs of nerves
 Fxn is to conduct nerve
impulses& serve for
spinal reflex centers
 Spinal tap – withdrawal
of CSF (2-3 ml);
decreases pressure
and can diagnose
problems
Peripheral Nervous System
 Nerves and ganglia outside the central
nervous system
 Nerve = bundle of neuron fibers
 Neuron fibers are bundled by
connective tissue
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Slide 7.55
Classification of Nerves (PNS)
 Mixed nerves – both sensory and motor
fibers
 Afferent (sensory) nerves – carry
impulses toward the CNS
 Efferent (motor) nerves – carry impulses
away from the CNS
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Slide 7.57
PNS Structure
1. Sensory (afferent) division – nerve fibers
that convey impulses to the CNS from
sensory receptors
a. Somatic sensory fibers – impulses from skin,
skeletal muscles, and joints
b. Visceral sensory fibers – impulses from
visceral organs
PNS structure (cont.)
2. Motor (efferent) division – caries impulses
from the CNS to organs, muscles and
glands; causes a response
a. (somatic ( voluntary) nervous system – allows
voluntary contraction of skeletal muscles
b. Autonomic ( involuntary ) nervous system –
regulates involuntary actions, such as glands,
cardiac, and muscles
Autonomic Nervous System
 The involuntary branch of the nervous
system
 Consists of only motor nerves
 Divided into two divisions
 Sympathetic division
 Parasympathetic division
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Slide 7.67
Comparison of Somatic and
Autonomic Nervous Systems
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Figure 7.24
Slide 7.69
Anatomy of the Autonomic Nervous
System
Figure 7.25
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Slide 7.73
Autonomic Functioning
 Sympathetic – “fight-or-flight”
 Response to unusual stimulus
 Takes over to increase activities
 Remember as the “E” division = exercise,
excitement, emergency, and
embarrassment
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Slide
Autonomic Functioning
 Parasympathetic – housekeeping
activities
 Conserves energy
 Maintains daily necessary body functions
 Remember as the “D” division - digestion,
defecation, and diuresis
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Slide
Development Aspects of the
Nervous System
 The nervous system is formed during
the first month of embryonic
development
 Any maternal infection can have
extremely harmful effects
 The hypothalamus is one of the last
areas of the brain to develop
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Slide
Development Aspects of the
Nervous System
 No more neurons are formed after birth,
but growth and maturation continues for
several years (new evidence!)
 The brain reaches maximum weight as
a young adult
 However, we can always grow
dendrites!
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Slide
Nervous System Disorders
1. Cerebral palsy – neuromuscular disability
where voluntary muscles are poorly controlled;
causes by a temporary lack of oxygen to motor
areas of the brain during delivery
2. Spina bifada – results when vertebrae from
incompletely; part of the spinal cord is
functionless
3. Parkinson’s disease – disorder in the ganglia
characterized by shaking
Nervous System Disorders
4. Orthostatic hypertension – type of low blood
pressure resulting from changes in body position
(sympathetic)
5. Brain shrinkage – common but sped up in
boxers and alcoholics (both groups exhibit signs
of dementia unrelated to aging)
6. Epilepsy – characterized by seizures – caused
by sudden bursts of irregular electrical activity
in the brain