Download Eicosanoids as pro- and anti- inflammatory mediators (Block

08 B 1 - Eicosanoids as pro- and anti- inflammatory
mediators (Block seminar)
Date and Time: 12.-13.10.2011, 09.00 - 10.30
Location: Seminar room, Oudenarder Str. 16, 13347 Berlin
Lecturer: Prof. Hartmut Kühn (Charité, Institute of Biochemistry)
Description: Eicosanoids are potent pro- and anti-inflammatory mediators, which are
produced by cells of the adaptive and non-adaptive immune systems but also by somatic cells
of vertebrates. This seminar is intended to give an overview on biosynthesis and biological
implications of eicosanoids in response to stimulation of immune cells. After introducing
eicosanoids as pleiotropic lipid mediators their biosynthetic routes will be characterized and
target enzymes (COX,1, COX2, 5-LOX, 15-LOX) for pharmacological interventions will be
described with respect to the protein-chemical and enzymatic properties. A systematic
classification scheme of pro- and anti-inflammatory eicosanoids will be given and biologically
important eicosanoid receptors will be introduced. Finally, the seminar will cover the
pleiotropic effects of different classes of eicosanoid during the pathogenesis of inflammation
and will address the pros and conts of frequently employed anti-inflammatory drugs
interfering with eicosanoid biosynthesis.
Participants: Maximum 25