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Transcript
24.8 Fates of the Carbon Atoms from Amino Acids Carbon atoms from degraded amino acids are converted to the intermediates of the citric acid cycle or other pathways. Learning Goal Describe where carbon atoms from amino acids enter the citric acid cycle or other pathways. General, Organic, and Biological Chemistry: Structures of Life, 5/e Karen C. Timberlake © 2016 Pearson Education, Inc. Carbon Atoms from Amino Acids We can classify the amino acids according to the number of carbon atoms. • Amino acids that provide three-carbon compounds are converted to pyruvate. • Amino acids with four carbon atoms are converted to oxaloacetate. • Five-carbon amino acids provide α-ketoglutarate. Some amino acids are listed twice because they can enter different pathways to form citric acid cycle intermediates. General, Organic, and Biological Chemistry: Structures of Life, 5/e Karen C. Timberlake © 2016 Pearson Education, Inc. Amino Acid Pathways to Citric Acid Intermediates General, Organic, and Biological Chemistry: Structures of Life, 5/e Karen C. Timberlake © 2016 Pearson Education, Inc. Glucogenic and Ketogenic Amino Acids Amino acids are classified as • glucogenic if they generate pyruvate, α-ketoglutarate, succinyl-CoA, fumarate, or oxaloacete, which can be used to synthesize glucose. • ketogenic if they generate acetoacetyl-CoA or acetyl-CoA, which can form ketone bodies or fatty acids. General, Organic, and Biological Chemistry: Structures of Life, 5/e Karen C. Timberlake © 2016 Pearson Education, Inc. Study Check Match each of the following citric acid intermediates with the amino acid that provides its carbon skeleton: 1) pyruvate 2) fumarate 3) α-ketoglutarate A. cysteine B. glutamine C. aspartate D. serine General, Organic, and Biological Chemistry: Structures of Life, 5/e Karen C. Timberlake © 2016 Pearson Education, Inc. Solution Match each of the following citric acid intermediates with the amino acid that provides its carbon skeleton: 1) pyruvate 2) fumarate 3) α-ketoglutarate A. cysteine 1) Pyruvate B. glutamine 3) α-ketoglutarate C. aspartate 2) Fumarate D. serine 1) pyruvate General, Organic, and Biological Chemistry: Structures of Life, 5/e Karen C. Timberlake © 2016 Pearson Education, Inc.
