Download Monday, June 1 Registration 15:00 – Keynote Lecture 17:00 – 18:20

Monday, June 1
Registration
15:00 –
Keynote Lecture
17:00 – 18:20
THE IMPORTANCE OF TCR AFFINITY IN SELECTION AND RESPONSE
Michael Bevan
Tuesday, June 2
Session 1: Thymic microenvironments (1)
08:30 – 10:30
PHYLOGENETIC AND ONTOGENETIC ASPECTS OF THYMUS DEVELOPMENT
Thomas Boehm
TROPICAL ISLANDS AND STARRY NIGHTS: DEVELOPING A BIOGEOGRAPHY OF
THE THYMUS
Nancy Manley
CHARACTERIZATION OF FOXN1-POSITIVE CELLS IN THE POSTNATAL MOUSE
THYMUS
Manami Itoi
REGULATION OF THYMIC EPITHELIAL CELL DEVELOPMENT
Graham Anderson
DICER IS REQUIRED FOR THE POSTNATAL MAINTENANCE OF THE THYMIC
EPITHELIAL MICRO-ENVIRONMENT
Georg Holländer
DISRUPTING STEADY-STATE POSTNATAL MEDULLARY EPITHELIUM BY
CONDITIONAL KNOCKOUT OF FOXN1 GENE TRIGGERS THYMIC INVOLUTION
Dong-Ming Su
THE ROLE OF HOXA3 DURING THE EARLY THYMUS ORGANOGENESIS
Kyoko Masuda
10:30 – 11:00
Coffee Break
Tuesday, June 2
Session 2: Lymphoid progenitors and lineage commitment (1)
11:00 – 12:40
RETENTION AND TERMINATION OF MYELOID POTENTIAL IN T CELL
PROGENITORS
Hiroshi Kawamoto
PROGENITORS WITH LYMPHOID AND MYELOID POTENTIAL SETTLE THE ADULT
MOUSE THYMUS
Avinash Bhandoola
INTERLEUKIN 7 RECEPTOR-DRIVEN FATE MAPPING OF LYMPHOID PATHWAYS
Hans-Reimer Rodewald
NEW PERSPECTIVES ON THE T-LINEAGE COMMITMENT MECHANISM
Ellen Rothenberg
DEVELOPMENTAL POTENTIAL OF THE EARLIEST THYMIC MIGRANTS
Natalie Roberts
THYMIC PROGENITOR HOMING AND LYMPHOCYTE HOMEOSTASIS ARE LINKED
VIA S1P CONTROLLED EXPRESSION OF THYMIC P-SELECTIN/CCL25
Klaus Gossens
Tuesday, June 2
Session 3: Lymphoid progenitors and lineage commitment (2)
14:20 – 16:00
NOTCH SIGNALING AND PRE-T CELL SURVIVAL AT THE β-SELECTION
CHECKPOINT
Juan Carlos Zúñiga-Pflücker
PRE-TCR
SIGNALING
INACTIVATES
NOTCH1
TRANSCRIPTION
ANTAGONIZING E2A SIGNALING AT THE β-SELECTION CHECKPOINT
Warren Pear
BY
NOTCH AND LYMPHOCYTE DEVELOPMENT
Freddy Radtke
WHAT GOES UP MUST COME DOWN: THE CONSEQUENCES OF NOT TURNING
DOWN PRE-TCR INDUCED BETA-CATENIN
Jyoti Sen
INDUCTION OF T CELL DEVELOPMENT BY THE IMMOBILIZED NOTCH LIGAND
IN THE ABSENCE OF STROMAL CELLS
Tomokatsu Ikawa
CHARGED RESIDUES
b-SELECTION IN VIVO
Sho Yamasaki
IN
PRE-TCRa
ARE
CRITICAL FOR
AUTONOMOUS
ZEBRAFISH MODELS OF HEREDITARY T CELL LEUKEMIA PREDISPOSITION
Nikolaus Trede
16:00 – 16:30
Coffee Break
Tuesday, June 2
Session 4: Recognition and activation
16:30 – 18:30
CONTROL OF T CELL RECEPTOR EXPRESSION AND SIGNALLING OUTPUT ON
PRE-SELECTION CD4+CD8+ THYMOCYTES
Bernard Malissen
DYNAMIC ASSEMBLY OF SIGNALING COMPLEX FOR POSITIVE AND NEGATIVE
COSTIMULATION OF T CELL ACTIVATION
Takashi Saito
STIMULATION OF T CELL SUBSETS WITH CYTOKINE/ANTIBODY COMPLEXES
Jonathan Sprent
TCR SIGNALS MEDIATED BY THE SRC-FAMILY KINASES LCK AND FYN, AND
THEIR ROLE IN THE DIFFERENTIATION OF T CELLS
Rose Zamoyska
DOWN-REGULATION OF RUNX1 EXPRESSION BY TCR SIGNAL IS MEDIATED IN
AN AUTO-REGULATORY MECHANISM AND IS NECESSARY FOR MAXIMAL
INTERLEUKIN-2 PRODUCTION
Masanobu Satake
EPIDERMAL gdT CELLS SENSE CELLULAR DYSREGULATION AND INNATE
IMMUNE RESPONSES
Eri Shimura
GADS DELETION CONVERTS THE ab T-CELL LYMPHOPROLIFERATIVE DISORDER
AFFLICTING LATY136F MICE INTO A LYMPHO-PROLIFERATIVE DISORDER
INVOLVING γδ T-CELLS.
Hervé Luche
TEMPORAL REGULATION OF THYMIC DEVELOPMENT ALLOWS SELECTION OF
CD4 AND CD8 REPERTOIRES AT DIFFERENT SIGNALLING THRESHOLDS
Charles Sinclair
18:30 – 20:30
Poster Session
Wednesday, June 3
Session 5: Repertoire selection
08:30 – 10:20
HOW DOES THE TCR READ LIGAND AFFINITY?
Ed Palmer
FUNCTIONAL ADAPTATION OF THYMIC STROMAL CELLS FOR T CELL
REPERTOIRE SELECTION
Ludger Klein
POSITIVE SELECTION BY THYMOPROTEASOME-EXPRESSING THYMIC
EPITHELIAL CELLS SHAPES IMMUNOCOMPETENT REPERTOIRE OF CD8 T CELLS
Yousuke Takahama
INTRATHYMIC REGULATION OF GAMMA DELTA T CELL REPERTOIRE AND
FUNCTION
Adrian Hayday
BASIS FOR SELECTION OF MHC-INDEPENDENT ab T CELLS IN THE THYMUS
François Van Laethem
CENTRAL TOLERANCE INDUCTION BY ADOPTIVE TRANSFER OF DONOR
DENDRITIC CELLS
Hidehiro Kishimoto
THE EFFECT OF OVEREXPRESSION OF AN “IMMUNOPROTEASOME” SUBUNIT
BETA5I IN CORTEICAL THYMIC EPITHELIAL CELLS
Yan Xing
10:30 – 11:00
Coffee Break
Wednesday, June 3
Session 6: Thymocyte differentiation
10:50 – 12:40
CD4 CORECEPTOR PROTEINS PROMOTE HELPER OR CYTOTOXIC LINEAGE
FATES DEPENDING ONLY AND ENTIRELY ON THE CORECEPTOR GENE
ENCODING THEM
Alfred Singer
TRANSCRIPTIONAL CONTROL OF CD4/CD8 LINEAGE CHOICE
Ichiro Taniuchi
A NOTCH FEEDBACK LOOP PROMOTES CD8 LINEAGE DIFFERENTIATION IN THE
ABSENCE OF ZAP-70
Naomi Taylor
THE ZINC FINGER TRANSCRIPTION FACTOR Thpok REPRESSES CD8-LINEAGE
GENE EXPRESSION IN PERIPHERAL CD4+ T CELLS
Rémy Bosselut
EVIDENCE FOR THE COUPLING OF DNA REPLICATION CONTROL AND LINEAGE
CHOICE INTO CD4/8 THYMOCYTES
Takehito Sato
FOXP1 IS AN ESSENTIAL TRANSCRIPTIONAL REGULATOR FOR THE
GENERATION OF QUIESCENT T CELLS DURING THYMOCYTE DEVELOPMENT
Hui Hu
S1P1 IS SUFFICIENT TO ACCOUNT FOR THE ACQUISITION OF EGRESS
COMPETENCE BY SINGLE-POSITIVE THYMOCYTES
Marcus Zachariah
14:00 – 15:00
Poster Session
Wednesday, June 3
Session 7: Thymic microenvironments (2)
15:00 – 16:50
PROMISCUOUS GENE EXPRESSION IN THYMIC MEDULLARY EPITHELIAL
CELLS: HOW IS THIS GENE POOL SELECTED?
Bruno Kyewski
EPIGENETIC MARKS DEFINE AIRE REGULATION OF TARGET GENES
Pärt Peterson
AIRE-DEPENDENT ORGANIZATION OF THYMIC MICROENVIRONMENT
Mitsuru Matsumoto
AIRE AND THYMIC EPITHELIAL CELL DEATH
Daniel Gray
ONTOGENY AND REGULATION OF PROMISCUOUS GENE EXPRESSION: A STUDY
OF THE CASEIN GENE LOCUS
Jens Derbinski
DIRECT ANTIGEN PRESENTATION BY MEDULLARY THYMIC EPITHELIAL CELLS
IS ESSENTIAL FOR CD4 T CELL TOLERANCE
Maria Hinterberger
SELF-ANTIGEN EXPRESSION IN EXTRATHYMIC
PREVENTS ANTIGEN-SPECIFIC AUTOIMMUNITY
James Gardner
16:50 – 17:20
Coffee Break
AIRE-EXPRESING
CELLS
Wednesday, June 3
Session 8: Thymic microenvironments (3)
17:20 – 19:10
TO BE ANNOUNCED
Mark Anderson
HETEROGENEITY OF EPITHELIAL CELLS EXPRESSING TISSUE-RESTRICTED
ANTIGENS IN THE THYMUS
Andrew Farr
COMPARATIVE IMMUNOMODULATING PROPERTIES OF
STROMAL CELLS AND AMNION EPITHELIAL STEM CELLS
Richard Boyd
MESENCHYMAL
EPITHIN ON THE THYMIC EPITHELIAL CELL REGULATES ANGIOPOIETIN
RECEPTOR TIE2 ON THE ENDOTHELIAL CELL
Moon Kim
DISTRIBUTION AND FUNCTION OF IL-7-PRODUCING STROMAL CELLS
Koichi Ikuta
ANALYSIS OF THYMIC MEDULLARY EPITHELIAL CELL SUBPOPULATIONS
Tomoo Ueno
MMP-19 AND THYMIC CONDUITS
Paulina Rymkiewicz
IDENTIFYING THE MOLECLAR FACTORS RESPONSIBLE FOR REGULATING
DELTA-LIKE 4 EXPRESSION ON THYMIC STROMA
Korosh Kianizad
19:30 – 21:30
Mixer
Thursday, June 4
Session 9: Immune response and memory (1)
08:30 – 10:30
SOURCE AND ROLE OF ENDOGENOUS ANTIGEN-SPECIFIC MEMORY CD8 T
CELLS IN UNPRIMED MICE
Stephen Jameson
T FOLLICULAR HELPER CELLS AND THE REGULATION OF ANTIBODY
RESPONSES
Charles Mackay
“NATURAL HELPER CELL” IN THE MESENTERY
Shigeo Koyasu
REGULATION OF T HELPER CELL LINEAGE DEVELOPMENT BY OSTEOPONTIN
Mari Shinohara
FALLOUT FROM THYMIC CATASTROPHY IN ADVANCED AGE – FUNCTIONAL
AND HOMEOSTATIC ASPECTS
Janko Nikolich-Zugich
PROFESSIONAL MEMORY CD4+ T LYMPHOCYTES RESIDE AND REST IN THE
BONE MARROW
Koji Tokoyoda
IDENTIFICATION OF CD25+ gd T CELLS AS FETAL THYMUS-DERIVED
NATURALLY OCCURRING IL-17 PRODUCERS
Kensuke Shibata
10:30 – 11:00
Coffee Break
Thursday, June 4
Session 10: Immune response and memory (2)
11:00 – 12:30
REGULATION OF MEMORY TH CELL SURVIVAL AND FUNCTION BY THE
POLYCOMB AND TRITHORAX GROUP GENE PRODUCTS
Toshinori Nakayama
MECHANISMS BEHIND POTENT ACTIVITY OF CYTOKINE/mAB COMPLEXES
Charles Surh
TO BE ANNOUNCED
Stephen Schoenberger
RUNX/CBF-B IS A CRITICAL GATEKEEPER THAT DIRECTS THE TH1 AND TH17
DIFFERENTIATION
Masato Kubo
GATA3 PREVENTS TH2 CELL IFN-GAMMA PRODUCTION BY REPRESSING
EOMESODERMIN EXPRESSION
Ryoji Yagi
Thursday, June 4
Session 11: Immune regulation and diseases (1)
14:10 – 15:30
A UNIQUE T CELL POPULATION UNDERLYING ALTERED IMMUNE TRAITS IN
SENESCENCE AND MALIGNANCY
Nagahiro Minato
RECONSTITUTION OF HUMAN IMMUNE SYSTEM IN MICE
Fumihiko Ishikawa
PD-1 REGULATES IL-2 PRODUCTION, WHICH INDUCES CD8+ T CELL ANERGY
Shunsuke Chikuma
CCR7-DEPENDENT S1P1 AND AP-1 SIGNALING IS
CD4+CD25+FOXP3+ REGULATORY T CELL FUNCTION IN VIVO
Naozumi Ishimaru
ESSENTIAL
FOR
LIVER AS A REGULATOR OF T CELLS
Masaaki Murakami
A CELL AUTONOMOUS REQUIREMENT FOR TRAF6 IN THE DEVELOPMENT OF
NATURALLY OCCURING REGULATORY T CELLS
Yusuke Shimo
15:30 – 16:00
Coffee Break
Thursday, June 4
Session 12: Immune regulation and diseases (1)
16:00 – 17:00
TRANSCRIPTIONAL REGULATION IN CD4+CD25+ REGULATORY T CELLS
Masahide Tone
T-BET CONTROLS REGULATORY T CELL HOMEOSTASIS AND FUNCTION DURING
TYPE-1 INFLAMMATION
Daniel Campbell
T CELL SIGNALING, REGULATORY T CELLS, AND AUTOIMMUNE DISEASE
Shimon Sakaguchi
Closing Remarks
Posters
Category 1: Thymic microenvironments
001. SEARCHING FOR RESIDENT EPITHELIAL STEM CELLS IN THE ADULT
THYMUS
Ann Chidgey
002. ENGINEERED IN VIVO NICHES TO TRAP, MAINTAIN AND SPECIFY MOUSE
LYMPHOCYTE PROGENITORS
Lesly Calderon Dominguez
003. EPITHIN ON THE THYMIC EPITHELIAL CELL REGULATES ANGIOPOIETIN
RECEPTOR TIE2 ON THE ENDOTHELIAL CELL
Moon Gyo Kim
004. DISRUPTING STEADY-STATE POSTNATAL MEDULLARY EPITHELIUM BY
CONDITIONAL KNOCKOUT OF FOXN1 GENE TRIGGERS THYMIC INVOLUTION
Dong-Ming Su
005. THYMOCYTE- AND THYMIC-MEDULLA-INDEPENDENT EXPRESSION OF
THYMOPROTEASOME b5t IN THYMIC CORTICAL EPITHELIAL CELLS
Adiratna Mat Ripen
006. DLL4 IS INDISPENSABLE FOR THE DIFFERENTIATION OF DN TO DP STAGES
IN THE THYMUS
Katsuto Hozumi
007. GENERATION OF THE THIRD PHARYNGEAL POUCH-RELATED CELLS FROM
MOUSE EMBRYONIC STEM CELLS
Kyoko Hidaka
008. THE THYMUS.....FOLLOW ME!
Willem van Ewijk & Stijn Crobach
009. THE FUNCTION OF BMI-1 IN THE THYMIC EPITHELIAL CELLS
Yun Guo
010.
MEIS1
DEFICIENCY
IMPAIRS
THE
POSTNATAL
MICROENVIRONMENT TO INDUCE EARLY THYMIC INVOLUTION
Takehiro Hirayama
THYMIC
011. DISTRIBUTION AND FUNCTION OF IL-7-PRODUCING STROMAL CELLS
Koichi Ikuta
012. REVISITING THYMIC NURSE CELLS
Takeshi Nitta
013. MACROAUTOPHAGY INTERCROSS TO
PRESENTATION IN THYMIC EPITHELIAL CELLS
Michiyuki Kasai
MHC
CLASS
II-ANTIGEN
014. THE ROLE OF HOXA3 DURING THE EARLY THYMUS ORGANOGENESIS
Kyoko Masuda
015. THYMIC CYSTS ORIGINATE FROM FOXN1 POSITIVE THYMIC MEDULLARY
EPITHELIUM
Eric Vroegindeweij
016. ENU-MUTAGENESIS IN ZEBRAFISH IDENTIFIES A SPECIFIC REQUIREMENT
FOR LSM8 IN THYMUS DEVELOPMENT
Norimasa Iwanami
017. MMP-19 AND THYMIC CONDUITS
Paulina Rymkiewicz
018. IDENTIFYING THE MOLECLAR FACTORS RESPONSIBLE FOR REGULATING
DELTA-LIKE 4 EXPRESSION ON THYMIC STROMA
Korosh Kianizad
019. FOXN1 IS REQUIRED FOR THYMIC VASCULARIZATION
Jerrod Bryson
020. ANALYSIS OF THYMIC MEDULLARY EPITHELIAL CELL SUBPOPULATIONS
Tomoo Ueno
021. ONTOGENY AND REGULATION OF PROMISCUOUS GENE EXPRESSION: A
STUDY OF THE CASEIN GENE LOCUS
Jens Derbinski
022. DIRECT ANTIGEN PRESENTATION BY MEDULLARY THYMIC EPITHELIAL
CELLS IS ESSENTIAL FOR CD4 T CELL TOLERANCE
Maria Hinterberger
023. THE ROLE OF CENTRAL TOLERANCE IN MEDIATING AUTOIMMUNE
PERIPHERAL NEUROPATHY
Maureen Su
024. SELF-ANTIGEN EXPRESSION IN EXTRATHYMIC AIRE-EXPRESING CELLS
PREVENTS ANTIGEN-SPECIFIC AUTOIMMUNITY
James Gardner
Posters
Category 2: Lymphoid progenitors and lineage commitment
025. REGULATION OF TCRb REARRANGEMENT AND EXPRESSION BY CD28
Karen Hathcock
026. WHAT GOES UP MUST COME DOWN: THE CONSEQUENCES OF NOT
TURNING DOWN PRE-TCR INDUCED BETA-CATENIN
Jyoti Misra Sen
027. ZEBRAFISH MODELS OF HEREDITARY T CELL LEUKEMIA PREDISPOSITION
Nikolaus Trede
028. AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN
Mlh1-DEFICIENT MICE
Shizuko Kakinuma
029. A POSSIBLE DEVELOPMENTAL PATHWAY OF FOXP3+ REGULATORY T CELLS
IN THE THYMUS
Naoko Nakano
030. GENERATION OF FUNCTIONAL T CELLS FROM ES CELLS AND INDUCED
PLURIPOTENT STEM (IPS) CELLS IN VITRO
Haruka Wada
031. INDUCTION OF T CELL DEVELOPMENT BY THE IMMOBILIZED NOTCH
LIGAND IN THE ABSENCE OF STROMAL CELLS
Tomokatsu Ikawa
032. CHARGED RESIDUES IN PRE-TCRa ARE CRITICAL FOR AUTONOMOUS
b-SELECTION IN VIVO
Sho Yamasaki
033. ADOPTIVE T/NK CELL PROGENITOR THERAPY FOR PATIENTS UNDERGOING
HSC-TRANSPLANTATION
Bob Meek
034. INTRATHYMIC TRANSPLANTATION OF BONE
PROGENITORS PROVIDES LONG-TERM THYMOPOIESIS
Rita Vicente
MARROW
DERIVED
035. DEVELOPMENTAL POTENTIAL OF THE EARLIEST THYMIC MIGRANTS
Natalie Roberts
036. SUBVERSION OF PKCALPHA CAUSES LINEAGE PLASTICITY ON PRO-B
CELLS
Rinako Nakagawa
037. LMO2-ASSOCIATED T-CELL LYMPHOBLASTIC LEUKAEMIA IS INITIATED
THROUGH THYMOCYTE SELF-RENEWAL
Matthew McCormack
038. THYMIC PROGENITOR HOMING AND LYMPHOCYTE HOMEOSTASIS ARE
LINKED VIA S1P CONTROLLED EXPRESSION OF THYMIC P-SELECTIN/CCL25
Klaus Gossens
039. HEBAlt RESCUES T CELL DEVELOPMENT IN HEB-DEFICIENT PRECURSORS
FROM ARREST AT TCRb-SELECTION CHECKPOINT
Marsela Braunstein
040. DNA DAMAGE RESPONSES TO VDJ-ASSOCIATED DOUBLE STRAND BREAKS
IN DEVELOPING T CELLS
Steven Bowen
Posters
Category 3: Selection and differentiation
041. CYTOKINE SIGNALING INDUCES RUNX3 AND SPECIFIES CD8 LINEAGE
CHOICE DURING CD4/CD8 CELL FATE DECISION IN THE THYMUS
Jung-Hyun Park
042. BASIS FOR SELECTION OF MHC-INDEPENDENT ab T CELLS IN THE THYMUS
François Van Laethem
043. FOXP1 IS AN ESSENTIAL TRANSCRIPTIONAL REGULATOR FOR THE
GENERATION OF QUIESCENT T CELLS DURING THYMOCYTE DEVELOPMENT
Hui Hu
044. RETINOIC ACID AND THYMOCYTE DEVELOPMENT
Katarzyna Sitnik
045. A NOVEL GENE ISC4 IS CRITICALLY REQUIRED FOR POSITIVE SELECTION
OF THYMOCYTES
Harumi Suzuki
046. AN EXAMPLE
LYMPHOMAGENESIS
Shinji Fujimoto
OF
NEGATIVE
SELECTION
DURING
THYMIC
047. CLAUDIN EXPRESSION IN THYMOCYTES: IMPLICATION IN T CELL
DEVELOPMENT
Yoko Hamazaki
048. DOSE-DEPENDENT EFFECT OF ZINC-FINGER TRANSCRIPTIONAL FACTOR
Rit1/Bcl11b ON DIFFERENTIATION OF CYTOTOXIC T CELLS
Satoshi Hirose
049. CENTRAL TOLERANCE INDUCTION BY ADOPTIVE TRANSFER OF DONOR
DENDRITIC CELLS
Hidehiro Kishimoto
050. EVIDENCE FOR THE COUPLING OF DNA REPLICATION CONTROL AND
LINEAGE CHOICE INTO CD4/8 THYMOCYTES
Takehito Sato
051. GENETIC EVIDENCE FOR DISTINCT REGULATION OF ThPOK SILENCER AT
DIFFERENT STAGES OF THYMOCYTE DEVELOPMENT
Hirokazu Tanaka
052. FORCED EXPRESSION OF FILAMIN A MAY DECREASE DOUBLE POSITIVE
THYMOCYTES DURING THYMOCYTE DEVELOPMENT
Toshio Watanabe
053. INDUCTION OF PRO-APOTOTIC SIGNALS VIA THE CD28 IN THE THYMUS
T Yamano
054. TEMPORAL REGULATION OF THYMIC DEVELOPMENT ALLOWS SELECTION
OF CD4 AND CD8 REPERTOIRES AT DIFFERENT SIGNALLING THRESHOLDS
Charles Sinclair
055. RARE DEVELOPMENT OF FOXP3+ THYMOCYTES IN THE CD4+CD8+ SUBSET
Hyang-Mi Lee
056. POLARITY PROTEINS IN
THYMOCYTE DEVELOPMENT
Pham Kim
ASYMMETRIC
057. INTRACLONAL COMPETITION
DETERMINATION IN THE THYMUS
Jhoanne Bautista
LIMITS
CELL
DIVISION
DURING
REGULATORY T CELL FATE
058. S1P1 IS SUFFICIENT TO ACCOUNT FOR THE ACQUISITION OF EGRESS
COMPETENCE BY SINGLE-POSITIVE THYMOCYTES
Marcus Zachariah
059. THE EFFECT OF OVEREXPRESSION OF AN “IMMUNOPROTEASOME”
SUBUNIT BETA5I IN CORTEICAL THYMIC EPITHELIAL CELLS
Yan Xing
Posters
Category 4: Recognition and activation
060. THE RhoA EFFECTER mDia1 REGULATE MOTILITY AND FUNCTION IN T
LYMPHOCYTES
Gyohei Egawa
061. THE TYROSINE PHOSPHORYLATION OF CD28 AND CD28 MEDIATED
COSTIMULATION
Shuhei Ogawa
062. DOWN-REGULATION OF RUNX1 EXPRESSION BY TCR SIGNAL IS MEDIATED
IN AN AUTO-REGULATORY MECHANISM AND IS NECESSARY FOR MAXIMAL
INTERLEUKIN-2 PRODUCTION
Masanobu Satake
063. MOLECULAR MECHANISM CONTROLLING INTRACELLULAR DOCK2
DYNAMICS DURING NEUTROPHIL CHEMOTAXIS
Akihiko Nishikimi
064. EPIDERMAL gdT CELLS SENSE CELLULAR DYSREGULATION AND INNATE
IMMUNE RESPONSES
Eri Shimura
065. SELF-ASSEMBLED CATIONIC NANOGEL-MEDIATED EFFICIENT PROTEIN
DELIVERY IN MOUSE PRIMARY T CELLS
Takeshi Tsubata
066. ACCELERATED TUMOR GROWTH IN MICE DEFICIENT IN DNAM-1
RECEPTOR
Kazuko Shibuya
067. TCR MICROCLUSTERS MOVE ALONG MICROTUBLES IN EARLY T CELL
ACTIVATION
Akiko Hashimoto-Tane
068. GADS DELETION CONVERTS THE ab T-CELL LYMPHOPROLIFERATIVE
DISORDER AFFLICTING LATY136F MICE INTO A LYMPHO-PROLIFERATIVE
DISORDER INVOLVING γδ T-CELLS.
Hervé Luche
069. MICRORNA-MEDIATED REGULATION OF T CELL TOLERANCE AND
DIFFERENTIATION
Di Yu
Posters
Category 5: Immune response and memory
070. COMPARATIVE ANALYSIS OF LYMPHOCYTES FROM MOUSE STRAINS WITH
DIFFERING SUSCEPTIBILITY TO EXPERIMENTAL ASTHMA
Damon J Tumes
071. GATA3 PREVENTS TH2 CELL IFN-GAMMA PRODUCTION BY REPRESSING
EOMESODERMIN EXPRESSION
Ryoji Yagi
072. INITIATION OF INFLAMMATORY SKIN RESPONSES BY PROMOTING TH
DIFFERENTIATION THROUGH PROSTAGLANDIN I RECEPTOR IP
Saeko Nakajima
073. TRANSCRIPTIONAL REGULATION OF Il9r IN RADIATION-INDUCED MOUSE
T-CELL LYMPHOMA CELL LINE
Yi Shang
074. IDENTIFICATION OF CD25+ gd T CELLS AS FETAL THYMUS-DERIVED
NATURALLY OCCURRING IL-17 PRODUCERS
Kensuke Shibata
075. PROFESSIONAL MEMORY CD4+ T LYMPHOCYTES RESIDE AND REST IN THE
BONE MARROW
Koji Tokoyoda
076. IL-4 AND IL-21 INVERSELY REGULATE CXCR4 EXPRESSION ON ACTIVATED B
CELLS
Nobuya Yoshida
077. INDUCTION OF TH1-TYPE IMMUNE RESPONSE THROUGH IFN-β BY LACTIC
ACID BACTERIA
Noriko M Tsuji
078. THE FUNCTION OF CD69 MOLECULES ON DENDRITIC CELLS TO INDUCE
IL-17 PRODUCING CELLS
Keiko Sawada
079. “NATURAL HELPER CELL” IN THE MESENTERY
Kazuyo Moro
080. MEMORY-LIKE CD8+ T CELLS REQUIRE ANTIGEN-SPECIFIC CD4 HELP TO
INDUCE AUTOIMMUNITY UNDER LYMPHOPENIC CONDITIONS
Cécile Le Saout
081. BASIS FOR IL-7’S FUNCTION AS A HOMEOSTATIC CYTOKINE
Motoko Kimura
082. SELF MHC CLASS I SUPPORTS SURVIVAL OF NAÏVE CD8+ T CELLS BUT
DEPRESS THEIR SENSITIVITY THROUGH DOWNREGULATION OF CD8 LEVELS
Kensuke Takada
Posters
Category 6: Immune regulation and diseases
083. ANTIBODY-MEDIATED BLOCKADE OF IL-15 REVERSES THE AUTOIMMUNE
INTESTINAL DAMAGE IN TRANSGENIC MICE THAT OVEREXPRESS IL-15 IN
ENTEROCYTES
Liyanage P. Perera
084. FUNCTIONALITY OF REGULATORY T CELLS REQUIRE PERSISTENT IN VIVO
COSTIMULATION TO MAINTAIN CTLA-4 EXPRESSION
Xuguang Tai
085. PD-1 REGULATES IL-2 PRODUCTION, WHICH INDUCES CD8+ T CELL
ANERGY
Shunsuke Chikuma
086. CCR7-DEPENDENT S1P1 AND AP-1 SIGNALING IS ESSENTIAL FOR
CD4+CD25+FOXP3+ REGULATORY T CELL FUNCTION IN VIVO
Naozumi Ishimaru
087. PSGL-1 EXPRESSED CD4 T CELLS IN CULPRIT CORONARY ARTERY OF
ACUTE CORONARY SYNDROME
Keiko Gomita
088. A NOVEL MOUSE MODEL OF PBC-LIKE AUTOIMMUNE CHOLANGITIS AND
MULTIFOCAL EPITHELIAL INFLAMMATIONS TRIGGERED BY BACTERIAL
EXPOSURE
Ikuko Haruta
089. INCREASES IN THE PERCENTAGES OF CD43-LOW MEMORY AND
CD25+/CD127- REGULATORY T CELLS IN THE CD4 T-CELL POPULATIONS AMONG
A-BOMB SURVIVORS
Yoichiro Kusunoki
090. LIVER AS A REGULATOR OF T CELLS
Masaaki Murakami
091. CHARACTERIZATION OF REGULATORY T CELLS MIGRATED FROM SKIN TO
DRAINING LYMPH NODE USING KAEDE-TRANSGENIC MICE
Michio Tomura
092. ELUCIDATING REGULATORY T CELLS TCR SPECIFICITY AND REPERTOIRE: A
NEW MOUSE MODEL
Maria Mariotti-Ferrandiz
093. THE FUNCTION OF SEC8 MOLECULES, A SUBUNIT OF EXOCYST COMPLEX, IN
INFLAMMATORY CELLS.
Misuzu Okada
094. CONTROL MECHANISMS IN MATURE T CELL LEUKEMIA/LYMPHOMA
Sebastian Newrzela
095. DEFECTIVE ENTERIC TOLERANCE IN CHRONICALLY LYMPHOPENIC MICE IS
NOT TRIGGERED BY ENTERIC BACTERIA, BUT BY ABSENCE OF T CELL
REPERTOIRES
Joon Youb Lee
096. AGING INCREASES SUSCEPTIBILITY TO SYSTEMIC INFECTION WITH L.
MONOCYTOGENES VIA T-CELL DEFECTS
Megan Smithey
097. A CELL AUTONOMOUS REQUIREMENT FOR TRAF6 IN THE DEVELOPMENT
OF NATURALLY OCCURING REGULATORY T CELLS
Yusuke Shimo