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Monday, June 1 Registration 15:00 – Keynote Lecture 17:00 – 18:20 Chaired by Takashi Saito THE IMPORTANCE OF TCR AFFINITY IN SELECTION AND RESPONSE Michael Bevan Tuesday, June 2 Session 1: Thymic microenvironments (1) PHYLOGENETIC AND ONTOGENETIC ASPECTS OF THYMUS DEVELOPMENT Thomas Boehm TROPICAL ISLANDS AND STARRY NIGHTS: DEVELOPING A BIOGEOGRAPHY OF THE THYMUS Nancy Manley CHARACTERIZATION OF FOXN1-POSITIVE CELLS IN THE POSTNATAL MOUSE THYMUS Manami Itoi REGULATION OF THYMIC EPITHELIAL CELL DEVELOPMENT Graham Anderson DICER IS REQUIRED FOR THE POSTNATAL MAINTENANCE OF THE THYMIC EPITHELIAL MICRO-ENVIRONMENT Georg Holländer DISRUPTING STEADY-STATE POSTNATAL MEDULLARY EPITHELIUM BY CONDITIONAL KNOCKOUT OF FOXN1 GENE TRIGGERS THYMIC INVOLUTION Dong-Ming Su THE ROLE OF HOXA3 DURING THE EARLY THYMUS ORGANOGENESIS Kyoko Masuda 10:30 – 11:00 Coffee Break Tuesday, June 2 Session 2: Lymphoid progenitors and lineage commitment (1) RETENTION AND TERMINATION OF MYELOID POTENTIAL IN T CELL PROGENITORS Hiroshi Kawamoto PROGENITORS WITH LYMPHOID AND MYELOID POTENTIAL SETTLE THE ADULT MOUSE THYMUS Avinash Bhandoola INTERLEUKIN 7 RECEPTOR-DRIVEN FATE MAPPING OF LYMPHOID PATHWAYS Hans-Reimer Rodewald NEW PERSPECTIVES ON THE T-LINEAGE COMMITMENT MECHANISM Ellen Rothenberg DEVELOPMENTAL POTENTIAL OF THE EARLIEST THYMIC MIGRANTS Natalie Roberts THYMIC PROGENITOR HOMING AND LYMPHOCYTE HOMEOSTASIS ARE LINKED VIA S1P CONTROLLED EXPRESSION OF THYMIC P-SELECTIN/CCL25 Klaus Gossens Tuesday, June 2 Session 3: Lymphoid progenitors and lineage commitment (2) NOTCH SIGNALING AND PRE-T CELL SURVIVAL AT THE β-SELECTION CHECKPOINT Juan Carlos Zúñiga-Pflücker PRE-TCR SIGNALING INACTIVATES NOTCH1 TRANSCRIPTION ANTAGONIZING E2A SIGNALING AT THE β-SELECTION CHECKPOINT Warren Pear BY NOTCH AND LYMPHOCYTE DEVELOPMENT Freddy Radtke WHAT GOES UP MUST COME DOWN: THE CONSEQUENCES OF NOT TURNING DOWN PRE-TCR INDUCED BETA-CATENIN Jyoti Sen INDUCTION OF T CELL DEVELOPMENT BY THE IMMOBILIZED NOTCH LIGAND IN THE ABSENCE OF STROMAL CELLS Tomokatsu Ikawa CHARGED RESIDUES b-SELECTION IN VIVO Sho Yamasaki 15:50 – 16:20 IN PRE-TCRa ARE Coffee Break CRITICAL FOR AUTONOMOUS Tuesday, June 2 Session 4: Recognition and activation CONTROL OF T CELL RECEPTOR EXPRESSION AND SIGNALLING OUTPUT ON PRE-SELECTION CD4+CD8+ THYMOCYTES Bernard Malissen DYNAMIC ASSEMBLY OF SIGNALING COMPLEX FOR POSITIVE AND NEGATIVE COSTIMULATION OF T CELL ACTIVATION Takashi Saito STIMULATION OF T CELL SUBSETS WITH CYTOKINE/ANTIBODY COMPLEXES Jonathan Sprent TCR SIGNALS MEDIATED BY THE SRC-FAMILY KINASES LCK AND FYN, AND THEIR ROLE IN THE DIFFERENTIATION OF T CELLS Rose Zamoyska DOWN-REGULATION OF RUNX1 EXPRESSION BY TCR SIGNAL IS MEDIATED IN AN AUTO-REGULATORY MECHANISM AND IS NECESSARY FOR MAXIMAL INTERLEUKIN-2 PRODUCTION Masanobu Satake EPIDERMAL gdT CELLS SENSE CELLULAR DYSREGULATION AND INNATE IMMUNE RESPONSES Eri Shimura GADS DELETION CONVERTS THE ab T-CELL LYMPHOPROLIFERATIVE DISORDER AFFLICTING LATY136F MICE INTO A LYMPHO-PROLIFERATIVE DISORDER INVOLVING γδ T-CELLS. Hervé Luche TEMPORAL REGULATION OF THYMIC DEVELOPMENT ALLOWS SELECTION OF CD4 AND CD8 REPERTOIRES AT DIFFERENT SIGNALLING THRESHOLDS Charles Sinclair A NOVEL GENE ISC4 IS CRITICALLY REQUIRED FOR POSITIVE SELECTION OF THYMOCYTES Harumi Suzuki 18:30 – 20:30 Poster Session Wednesday, June 3 Session 5: Repertoire selection HOW DOES THE TCR READ LIGAND AFFINITY? Ed Palmer FUNCTIONAL ADAPTATION OF THYMIC STROMAL CELLS FOR T CELL REPERTOIRE SELECTION Ludger Klein POSITIVE SELECTION BY THYMOPROTEASOME-EXPRESSING THYMIC EPITHELIAL CELLS SHAPES IMMUNOCOMPETENT REPERTOIRE OF CD8 T CELLS Yousuke Takahama INTRATHYMIC REGULATION OF GAMMA DELTA T CELL REPERTOIRE AND FUNCTION Adrian Hayday BASIS FOR SELECTION OF MHC-INDEPENDENT ab T CELLS IN THE THYMUS François Van Laethem CENTRAL TOLERANCE INDUCTION BY ADOPTIVE TRANSFER OF DONOR DENDRITIC CELLS Hidehiro Kishimoto THE EFFECT OF OVEREXPRESSION OF AN “IMMUNOPROTEASOME” SUBUNIT BETA5I IN CORTEICAL THYMIC EPITHELIAL CELLS Yan Xing 10:30 – 11:00 Coffee Break Wednesday, June 3 Session 6: Thymocyte differentiation CD4 CORECEPTOR PROTEINS PROMOTE HELPER OR CYTOTOXIC LINEAGE FATES DEPENDING ONLY AND ENTIRELY ON THE CORECEPTOR GENE ENCODING THEM Alfred Singer TRANSCRIPTIONAL CONTROL OF CD4/CD8 LINEAGE CHOICE Ichiro Taniuchi A NOTCH FEEDBACK LOOP PROMOTES CD8 LINEAGE DIFFERENTIATION IN THE ABSENCE OF ZAP-70 Naomi Taylor THE ZINC FINGER TRANSCRIPTION FACTOR Thpok REPRESSES CD8-LINEAGE GENE EXPRESSION IN PERIPHERAL CD4+ T CELLS Rémy Bosselut EVIDENCE FOR THE COUPLING OF DNA REPLICATION CONTROL AND LINEAGE CHOICE INTO CD4/8 THYMOCYTES Takehito Sato FOXP1 IS AN ESSENTIAL TRANSCRIPTIONAL REGULATOR FOR THE GENERATION OF QUIESCENT T CELLS DURING THYMOCYTE DEVELOPMENT Hui Hu S1P1 IS SUFFICIENT TO ACCOUNT FOR THE ACQUISITION OF EGRESS COMPETENCE BY SINGLE-POSITIVE THYMOCYTES Marcus Zachariah 14:00 – 15:00 Poster Session Wednesday, June 3 Session 7: Thymic microenvironments (2) PROMISCUOUS GENE EXPRESSION IN THYMIC MEDULLARY EPITHELIAL CELLS: HOW IS THIS GENE POOL SELECTED? Bruno Kyewski EPIGENETIC MARKS DEFINE AIRE REGULATION OF TARGET GENES Pärt Peterson AIRE-DEPENDENT ORGANIZATION OF THYMIC MICROENVIRONMENT Mitsuru Matsumoto AIRE AND THYMIC EPITHELIAL CELL DEATH Daniel Gray ONTOGENY AND REGULATION OF PROMISCUOUS GENE EXPRESSION: A STUDY OF THE CASEIN GENE LOCUS Jens Derbinski DIRECT ANTIGEN PRESENTATION BY MEDULLARY THYMIC EPITHELIAL CELLS IS ESSENTIAL FOR CD4 T CELL TOLERANCE Maria Hinterberger SELF-ANTIGEN EXPRESSION IN EXTRATHYMIC PREVENTS ANTIGEN-SPECIFIC AUTOIMMUNITY James Gardner 16:50 – 17:20 Coffee Break AIRE-EXPRESING CELLS Wednesday, June 3 Session 8: Thymic microenvironments (3) IMMUNOLOGICAL IMPRINT OF TOLERANCE IMPARTED BY THE AUTOIMMUNE REGULATOR Mark Anderson HETEROGENEITY OF EPITHELIAL CELLS EXPRESSING TISSUE-RESTRICTED ANTIGENS IN THE THYMUS Andrew Farr COMPARATIVE IMMUNOMODULATING PROPERTIES OF STROMAL CELLS AND AMNION EPITHELIAL STEM CELLS Richard Boyd MESENCHYMAL EPITHIN ON THE THYMIC EPITHELIAL CELL REGULATES ANGIOPOIETIN RECEPTOR TIE2 ON THE ENDOTHELIAL CELL Moon Kim DISTRIBUTION AND FUNCTION OF IL-7-PRODUCING STROMAL CELLS Koichi Ikuta ANALYSIS OF THYMIC MEDULLARY EPITHELIAL CELL SUBPOPULATIONS Tomoo Ueno MMP-19 AND THYMIC CONDUITS Paulina Rymkiewicz IDENTIFYING THE MOLECLAR FACTORS RESPONSIBLE FOR REGULATING DELTA-LIKE 4 EXPRESSION ON THYMIC STROMA Korosh Kianizad 19:30 – 21:30 Mixer Thursday, June 4 Session 9: Immune response and memory (1) SOURCE AND ROLE OF ENDOGENOUS ANTIGEN-SPECIFIC MEMORY CD8 T CELLS IN UNPRIMED MICE Stephen Jameson T FOLLICULAR HELPER CELLS AND THE REGULATION OF ANTIBODY RESPONSES Charles Mackay “NATURAL HELPER CELL” IN THE MESENTERY Shigeo Koyasu REGULATION OF T HELPER CELL LINEAGE DEVELOPMENT BY OSTEOPONTIN Mari Shinohara FALLOUT FROM THYMIC CATASTROPHY IN ADVANCED AGE – FUNCTIONAL AND HOMEOSTATIC ASPECTS Janko Nikolich-Zugich PROFESSIONAL MEMORY CD4+ T LYMPHOCYTES RESIDE AND REST IN THE BONE MARROW Koji Tokoyoda IDENTIFICATION OF CD25+ T CELLS NATURALLY OCCURRING IL-17 PRODUCERS Kensuke Shibata 10:30 – 11:00 Coffee Break AS FETAL THYMUS-DERIVED Thursday, June 4 Session 10: Immune response and memory (2) REGULATION OF MEMORY TH CELL SURVIVAL AND FUNCTION BY THE POLYCOMB AND TRITHORAX GROUP GENE PRODUCTS Toshinori Nakayama MECHANISMS BEHIND POTENT ACTIVITY OF CYTOKINE/mAB COMPLEXES Charles Surh MOLECULAR DETERMINANTS OF CD8+ T CELL MEMORY Stephen Schoenberger RUNX/CBF-B IS A CRITICAL GATEKEEPER THAT DIRECTS THE TH1 AND TH17 DIFFERENTIATION Masato Kubo GATA3 PREVENTS TH2 CELL IFN-GAMMA PRODUCTION BY REPRESSING EOMESODERMIN EXPRESSION Ryoji Yagi Thursday, June 4 Session 11: Immune regulation and diseases (1) A UNIQUE T CELL POPULATION UNDERLYING ALTERED IMMUNE TRAITS IN SENESCENCE AND MALIGNANCY Nagahiro Minato RECONSTITUTION OF HUMAN IMMUNE SYSTEM IN MICE Fumihiko Ishikawa PD-1 REGULATES IL-2 PRODUCTION, WHICH INDUCES CD8+ T CELL ANERGY Shunsuke Chikuma CCR7-DEPENDENT S1P1 AND AP-1 SIGNALING IS CD4+CD25+FOXP3+ REGULATORY T CELL FUNCTION IN VIVO Naozumi Ishimaru ESSENTIAL FOR LIVER AS A REGULATOR OF T CELLS Masaaki Murakami A CELL AUTONOMOUS REQUIREMENT FOR TRAF6 IN THE DEVELOPMENT OF NATURALLY OCCURING REGULATORY T CELLS Yusuke Shimo 15:30 – 16:00 Coffee Break Thursday, June 4 Session 12: Immune regulation and diseases (1) TRANSCRIPTIONAL REGULATION IN CD4+CD25+ REGULATORY T CELLS Masahide Tone T-BET CONTROLS REGULATORY T CELL HOMEOSTASIS AND FUNCTION DURING TYPE-1 INFLAMMATION Daniel Campbell T CELL SIGNALING, REGULATORY T CELLS, AND AUTOIMMUNE DISEASE Shimon Sakaguchi Closing Remarks Posters Category 1: Thymic microenvironments 001. SEARCHING FOR RESIDENT EPITHELIAL STEM CELLS IN THE ADULT THYMUS Ann Chidgey 002. ENGINEERED IN VIVO NICHES TO TRAP, MAINTAIN AND SPECIFY MOUSE LYMPHOCYTE PROGENITORS Lesly Calderon Dominguez 003. EPITHIN ON THE THYMIC EPITHELIAL CELL REGULATES ANGIOPOIETIN RECEPTOR TIE2 ON THE ENDOTHELIAL CELL Moon Gyo Kim 004. DISRUPTING STEADY-STATE POSTNATAL MEDULLARY EPITHELIUM BY CONDITIONAL KNOCKOUT OF FOXN1 GENE TRIGGERS THYMIC INVOLUTION Dong-Ming Su 005. THYMOCYTE- AND THYMIC-MEDULLA-INDEPENDENT EXPRESSION OF THYMOPROTEASOME b5t IN THYMIC CORTICAL EPITHELIAL CELLS Adiratna Mat Ripen 006. DLL4 IS INDISPENSABLE FOR THE DIFFERENTIATION OF DN TO DP STAGES IN THE THYMUS Katsuto Hozumi 007. GENERATION OF THE THIRD PHARYNGEAL POUCH-RELATED CELLS FROM MOUSE EMBRYONIC STEM CELLS Kyoko Hidaka 008. THE THYMUS.....FOLLOW ME! Willem van Ewijk & Stijn Crobach 009. THE FUNCTION OF BMI-1 IN THE THYMIC EPITHELIAL CELLS Yun Guo 010. MEIS1 DEFICIENCY IMPAIRS THE POSTNATAL MICROENVIRONMENT TO INDUCE EARLY THYMIC INVOLUTION Takehiro Hirayama THYMIC 011. DISTRIBUTION AND FUNCTION OF IL-7-PRODUCING STROMAL CELLS Koichi Ikuta 012. REVISITING THYMIC NURSE CELLS Takeshi Nitta 013. MACROAUTOPHAGY INTERCROSS TO PRESENTATION IN THYMIC EPITHELIAL CELLS Michiyuki Kasai MHC CLASS II-ANTIGEN 014. THE ROLE OF HOXA3 DURING THE EARLY THYMUS ORGANOGENESIS Kyoko Masuda 015. THYMIC CYSTS ORIGINATE FROM FOXN1 POSITIVE THYMIC MEDULLARY EPITHELIUM Eric Vroegindeweij 016. ENU-MUTAGENESIS IN ZEBRAFISH IDENTIFIES A SPECIFIC REQUIREMENT FOR LSM8 IN THYMUS DEVELOPMENT Norimasa Iwanami 017. MMP-19 AND THYMIC CONDUITS Paulina Rymkiewicz 018. IDENTIFYING THE MOLECLAR FACTORS RESPONSIBLE FOR REGULATING DELTA-LIKE 4 EXPRESSION ON THYMIC STROMA Korosh Kianizad 019. FOXN1 IS REQUIRED FOR THYMIC VASCULARIZATION Jerrod Bryson 020. ANALYSIS OF THYMIC MEDULLARY EPITHELIAL CELL SUBPOPULATIONS Tomoo Ueno 021. ONTOGENY AND REGULATION OF PROMISCUOUS GENE EXPRESSION: A STUDY OF THE CASEIN GENE LOCUS Jens Derbinski 022. DIRECT ANTIGEN PRESENTATION BY MEDULLARY THYMIC EPITHELIAL CELLS IS ESSENTIAL FOR CD4 T CELL TOLERANCE Maria Hinterberger 023. THE ROLE OF CENTRAL TOLERANCE IN MEDIATING AUTOIMMUNE PERIPHERAL NEUROPATHY Maureen Su 024. SELF-ANTIGEN EXPRESSION IN EXTRATHYMIC AIRE-EXPRESING CELLS PREVENTS ANTIGEN-SPECIFIC AUTOIMMUNITY James Gardner Posters Category 2: Lymphoid progenitors and lineage commitment 025. REGULATION OF TCRb REARRANGEMENT AND EXPRESSION BY CD28 Karen Hathcock 026. WHAT GOES UP MUST COME DOWN: THE CONSEQUENCES OF NOT TURNING DOWN PRE-TCR INDUCED BETA-CATENIN Jyoti Misra Sen 027. ZEBRAFISH MODELS OF HEREDITARY T CELL LEUKEMIA PREDISPOSITION Nikolaus Trede 028. AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN Mlh1-DEFICIENT MICE Shizuko Kakinuma 029. A POSSIBLE DEVELOPMENTAL PATHWAY OF FOXP3+ REGULATORY T CELLS IN THE THYMUS Naoko Nakano 030. GENERATION OF FUNCTIONAL T CELLS FROM ES CELLS AND INDUCED PLURIPOTENT STEM (IPS) CELLS IN VITRO Haruka Wada 031. INDUCTION OF T CELL DEVELOPMENT BY THE IMMOBILIZED NOTCH LIGAND IN THE ABSENCE OF STROMAL CELLS Tomokatsu Ikawa 032. CHARGED RESIDUES IN PRE-TCRa ARE CRITICAL FOR AUTONOMOUS b-SELECTION IN VIVO Sho Yamasaki 033. ADOPTIVE T/NK CELL PROGENITOR THERAPY FOR PATIENTS UNDERGOING HSC-TRANSPLANTATION Bob Meek 034. INTRATHYMIC TRANSPLANTATION OF BONE PROGENITORS PROVIDES LONG-TERM THYMOPOIESIS Rita Vicente MARROW DERIVED 035. DEVELOPMENTAL POTENTIAL OF THE EARLIEST THYMIC MIGRANTS Natalie Roberts 036. SUBVERSION OF PKCALPHA CAUSES LINEAGE PLASTICITY ON PRO-B CELLS Rinako Nakagawa 037. LMO2-ASSOCIATED T-CELL LYMPHOBLASTIC LEUKAEMIA IS INITIATED THROUGH THYMOCYTE SELF-RENEWAL Matthew McCormack 038. THYMIC PROGENITOR HOMING AND LYMPHOCYTE HOMEOSTASIS ARE LINKED VIA S1P CONTROLLED EXPRESSION OF THYMIC P-SELECTIN/CCL25 Klaus Gossens Posters Category 3: Selection and differentiation 039. CYTOKINE SIGNALING INDUCES RUNX3 AND SPECIFIES CD8 LINEAGE CHOICE DURING CD4/CD8 CELL FATE DECISION IN THE THYMUS Jung-Hyun Park 040. BASIS FOR SELECTION OF MHC-INDEPENDENT ab T CELLS IN THE THYMUS François Van Laethem 041. FOXP1 IS AN ESSENTIAL TRANSCRIPTIONAL REGULATOR FOR THE GENERATION OF QUIESCENT T CELLS DURING THYMOCYTE DEVELOPMENT Hui Hu 042. RETINOIC ACID AND THYMOCYTE DEVELOPMENT Katarzyna Sitnik 043. A NOVEL GENE ISC4 IS CRITICALLY REQUIRED FOR POSITIVE SELECTION OF THYMOCYTES Harumi Suzuki 044. AN EXAMPLE LYMPHOMAGENESIS Shinji Fujimoto OF NEGATIVE SELECTION DURING THYMIC 045. CLAUDIN EXPRESSION IN THYMOCYTES: IMPLICATION IN T CELL DEVELOPMENT Yoko Hamazaki 046. DOSE-DEPENDENT EFFECT OF ZINC-FINGER TRANSCRIPTIONAL FACTOR Rit1/Bcl11b ON DIFFERENTIATION OF CYTOTOXIC T CELLS Satoshi Hirose 047. CENTRAL TOLERANCE INDUCTION BY ADOPTIVE TRANSFER OF DONOR DENDRITIC CELLS Hidehiro Kishimoto 048. EVIDENCE FOR THE COUPLING OF DNA REPLICATION CONTROL AND LINEAGE CHOICE INTO CD4/8 THYMOCYTES Takehito Sato 049. GENETIC EVIDENCE FOR DISTINCT REGULATION OF ThPOK SILENCER AT DIFFERENT STAGES OF THYMOCYTE DEVELOPMENT Hirokazu Tanaka 050. FORCED EXPRESSION OF FILAMIN A MAY DECREASE DOUBLE POSITIVE THYMOCYTES DURING THYMOCYTE DEVELOPMENT Toshio Watanabe 051. INDUCTION OF PRO-APOTOTIC SIGNALS VIA THE CD28 IN THE THYMUS T Yamano 052. TEMPORAL REGULATION OF THYMIC DEVELOPMENT ALLOWS SELECTION OF CD4 AND CD8 REPERTOIRES AT DIFFERENT SIGNALLING THRESHOLDS Charles Sinclair 053. RARE DEVELOPMENT OF FOXP3+ THYMOCYTES IN THE CD4+CD8+ SUBSET Hyang-Mi Lee 054. POLARITY PROTEINS IN THYMOCYTE DEVELOPMENT Pham Kim ASYMMETRIC 055. INTRACLONAL COMPETITION DETERMINATION IN THE THYMUS Jhoanne Bautista LIMITS CELL DIVISION DURING REGULATORY T CELL FATE 056. S1P1 IS SUFFICIENT TO ACCOUNT FOR THE ACQUISITION OF EGRESS COMPETENCE BY SINGLE-POSITIVE THYMOCYTES Marcus Zachariah 057. THE EFFECT OF OVEREXPRESSION OF AN “IMMUNOPROTEASOME” SUBUNIT BETA5I IN CORTEICAL THYMIC EPITHELIAL CELLS Yan Xing Posters Category 4: Recognition and activation 058. THE RhoA EFFECTER mDia1 REGULATE MOTILITY AND FUNCTION IN T LYMPHOCYTES Gyohei Egawa 059. THE TYROSINE PHOSPHORYLATION OF CD28 AND CD28 MEDIATED COSTIMULATION Shuhei Ogawa 060. DOWN-REGULATION OF RUNX1 EXPRESSION BY TCR SIGNAL IS MEDIATED IN AN AUTO-REGULATORY MECHANISM AND IS NECESSARY FOR MAXIMAL INTERLEUKIN-2 PRODUCTION Masanobu Satake 061. MOLECULAR MECHANISM CONTROLLING INTRACELLULAR DOCK2 DYNAMICS DURING NEUTROPHIL CHEMOTAXIS Akihiko Nishikimi 062. EPIDERMAL gdT CELLS SENSE CELLULAR DYSREGULATION AND INNATE IMMUNE RESPONSES Eri Shimura 063. SELF-ASSEMBLED CATIONIC NANOGEL-MEDIATED EFFICIENT PROTEIN DELIVERY IN MOUSE PRIMARY T CELLS Takeshi Tsubata 064. ACCELERATED TUMOR GROWTH IN MICE DEFICIENT IN DNAM-1 RECEPTOR Kazuko Shibuya 065. TCR MICROCLUSTERS MOVE ALONG MICROTUBLES IN EARLY T CELL ACTIVATION Akiko Hashimoto-Tane 066. GADS DELETION CONVERTS THE ab T-CELL LYMPHOPROLIFERATIVE DISORDER AFFLICTING LATY136F MICE INTO A LYMPHO-PROLIFERATIVE DISORDER INVOLVING γδ T-CELLS. Hervé Luche 067. MICRORNA-MEDIATED REGULATION OF T CELL TOLERANCE AND DIFFERENTIATION Di Yu Posters Category 5: Immune response and memory 068. COMPARATIVE ANALYSIS OF LYMPHOCYTES FROM MOUSE STRAINS WITH DIFFERING SUSCEPTIBILITY TO EXPERIMENTAL ASTHMA Damon J Tumes 069. GATA3 PREVENTS TH2 CELL IFN-GAMMA PRODUCTION BY REPRESSING EOMESODERMIN EXPRESSION Ryoji Yagi 070. INITIATION OF INFLAMMATORY SKIN RESPONSES BY PROMOTING TH DIFFERENTIATION THROUGH PROSTAGLANDIN I RECEPTOR IP Saeko Nakajima 071. TRANSCRIPTIONAL REGULATION OF Il9r IN RADIATION-INDUCED MOUSE T-CELL LYMPHOMA CELL LINE Yi Shang 072. IDENTIFICATION OF CD25+ gd T CELLS AS FETAL THYMUS-DERIVED NATURALLY OCCURRING IL-17 PRODUCERS Kensuke Shibata 073. PROFESSIONAL MEMORY CD4+ T LYMPHOCYTES RESIDE AND REST IN THE BONE MARROW Koji Tokoyoda 074. IL-4 AND IL-21 INVERSELY REGULATE CXCR4 EXPRESSION ON ACTIVATED B CELLS Nobuya Yoshida 075. INDUCTION OF TH1-TYPE IMMUNE RESPONSE THROUGH IFN-β BY LACTIC ACID BACTERIA Noriko M Tsuji 076. THE FUNCTION OF CD69 MOLECULES ON DENDRITIC CELLS TO INDUCE IL-17 PRODUCING CELLS Keiko Sawada 077. “NATURAL HELPER CELL” IN THE MESENTERY Kazuyo Moro 078. MEMORY-LIKE CD8+ T CELLS REQUIRE ANTIGEN-SPECIFIC CD4 HELP TO INDUCE AUTOIMMUNITY UNDER LYMPHOPENIC CONDITIONS Cécile Le Saout 079. BASIS FOR IL-7’S FUNCTION AS A HOMEOSTATIC CYTOKINE Motoko Kimura 080. SELF MHC CLASS I SUPPORTS SURVIVAL OF NAÏVE CD8+ T CELLS BUT DEPRESS THEIR SENSITIVITY THROUGH DOWNREGULATION OF CD8 LEVELS Kensuke Takada Posters Category 6: Immune regulation and diseases 081. ANTIBODY-MEDIATED BLOCKADE OF IL-15 REVERSES THE AUTOIMMUNE INTESTINAL DAMAGE IN TRANSGENIC MICE THAT OVEREXPRESS IL-15 IN ENTEROCYTES Liyanage P. Perera 082. FUNCTIONALITY OF REGULATORY T CELLS REQUIRE PERSISTENT IN VIVO COSTIMULATION TO MAINTAIN CTLA-4 EXPRESSION Xuguang Tai 083. PD-1 REGULATES IL-2 PRODUCTION, WHICH INDUCES CD8+ T CELL ANERGY Shunsuke Chikuma 084. CCR7-DEPENDENT S1P1 AND AP-1 SIGNALING IS ESSENTIAL FOR CD4+CD25+FOXP3+ REGULATORY T CELL FUNCTION IN VIVO Naozumi Ishimaru 085. PSGL-1 EXPRESSED CD4 T CELLS IN CULPRIT CORONARY ARTERY OF ACUTE CORONARY SYNDROME Keiko Gomita 086. A NOVEL MOUSE MODEL OF PBC-LIKE AUTOIMMUNE CHOLANGITIS AND MULTIFOCAL EPITHELIAL INFLAMMATIONS TRIGGERED BY BACTERIAL EXPOSURE Ikuko Haruta 087. INCREASES IN THE PERCENTAGES OF CD43-LOW MEMORY AND CD25+/CD127- REGULATORY T CELLS IN THE CD4 T-CELL POPULATIONS AMONG A-BOMB SURVIVORS Yoichiro Kusunoki 088. LIVER AS A REGULATOR OF T CELLS Masaaki Murakami 089. CHARACTERIZATION OF REGULATORY T CELLS MIGRATED FROM SKIN TO DRAINING LYMPH NODE USING KAEDE-TRANSGENIC MICE Michio Tomura 090. ELUCIDATING REGULATORY T CELLS TCR SPECIFICITY AND REPERTOIRE: A NEW MOUSE MODEL Maria Mariotti-Ferrandiz 091. THE FUNCTION OF SEC8 MOLECULES, A SUBUNIT OF EXOCYST COMPLEX, IN INFLAMMATORY CELLS. Misuzu Okada 092. CONTROL MECHANISMS IN MATURE T CELL LEUKEMIA/LYMPHOMA Sebastian Newrzela 093. DEFECTIVE ENTERIC TOLERANCE IN CHRONICALLY LYMPHOPENIC MICE IS NOT TRIGGERED BY ENTERIC BACTERIA, BUT BY ABSENCE OF T CELL REPERTOIRES Joon Youb Lee 094. AGING INCREASES SUSCEPTIBILITY TO SYSTEMIC INFECTION WITH L. MONOCYTOGENES VIA T-CELL DEFECTS Megan Smithey 095. A CELL AUTONOMOUS REQUIREMENT FOR TRAF6 IN THE DEVELOPMENT OF NATURALLY OCCURING REGULATORY T CELLS Yusuke Shimo