Download Photo of the Bubonic Plague ( Yersinia pestis)

Moving Bacterial Proteins Through the
Membranes
Chapter 16
Amy McCord
Photo of the Bubonic
Plague
( Yersinia pestis)
Yersinia pestis
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Bubonic plague, one of the deadliest diseases in
human history.
Kills by cutting off a cell's ability to communicate
with other immune system cells needed to fight off
the bacterial invasion.
One protein is responsible for the plague's lethal
effect, it is called YopJ.
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Every human cell has the ability to transmit signals
involved in the immune response and cell death .
YopJ, is the protein Yersinia uses to block this
signaling process.
How does YopJ get into your cells?
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Pathogenic bacteria use type III secretion
apparatus
Type III secretion apparatus consists of basal
portion that spans both membranes and an
extracellular needlelike structure that can
penetrate the plasma membrane of target cell.