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Giant cell tumor of bone. The photomicrograph depicts the two components of a giant cell tumor of bone, multinucleated giant cells, and mononuclear cells. The multinucleated giant cells are felt to be reactive in nature, and the mononuclear cells represent the neoplastic component of the tumor. Hematoxylin and eosin, 200×. Source: Chapter 19. Pathology of the Bones and Joints, Pathology: The Big Picture Citation: Kemp WL, Burns DK, Brown TG. Pathology: The Big Picture; 2008 Available at: http://mhmedical.com/ Accessed: May 12, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved