Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Bioinfomatics
Document related concepts
Transcript
BIOINFORMATICS LAUREN M. BANSBACH BIOL 546 15 NOVEMBER 2016 BIOINFORMATICS = COMPUTATIONAL MOLECULAR BIOLOGY Biology BIOINFORMATICS Probability & statistics Computer science VOLUME OF MOLECULAR SEQUENCE DATA IS GROWING EXPONENTIALLY COMPUTING POWER IS NOT KEEPING UP BIOINFORMATICS PIONEER: MARGARET OAKLEY DAYHOFF • Physical chemist and professor at Georgetown University Medical Center • Research biochemist and Associate Director at National Biomedical Research Foundation • Applied mathematical and computational methods to biochemistry • Compiled one of the first protein sequence databases • Atlas of Protein Sequence and Structure (1965) – all known protein sequences • Developed one letter codes for amino acids to reduce size of data files • Pioneered methods of sequence alignment and molecular evolution • Compared proteins to reconstruct their evolutionary history – first application of computers to infer phylogenies from molecular sequence BIOINFORMATICS WORKFLOW Raw Reads • Quality control Assemble Contigs • Reference Assembly • Experimental Assemblies Analysis Source: personal communication with Oliver Oviedo • Subcluster • Annotation GENOME ANNOTATION EXAMPLES OF BIOINFORMATICS DATA Subcluster graph Correlation matrix Data courtesy of Oliver Oviedo Source: Venture Beat Jan. 2013 POSSIBILITIES WITH BIOINFORMATICS • Sequence assembly • Genome annotation • Compare whole genomes • Phylogenetics and evolution • Disease association • Genome expression • Protein expression • Chromosome structure • Protein structure • Molecular interactions DEGREE PROGRAMS • Bioinformatics • Computational Biology • Medical Informatics
