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Activity How was the first man-made cell created? Step1: The scientists choose a bacteria that has one chromosome made up of many genes. • • Copy this diagram of the bacteria and label the chromosome and genes. What are genes made of? © Snapshot Science, 2010 Activity How was the first man-made cell created? Step2: They then used a computer to decode the genes and work out the order of bases in the DNA strand. A T G A A • C C T C G T A Copy and complete this part of DNA to show the missing bases. © Snapshot Science, 2010 Activity How was the first man-made cell created? Step 3: Using the code, they then used man-made bases to create the chromosome. They put in some extra pieces of DNA to prove that they had created the chromosome. These bases were in a special order to create a code that spelt out the scientists’ names plus an email address that you can email if you crack the code! © Snapshot Science, 2010 Activity How was the first man-made cell created? Step 4: They took the chromosome out of another bacteria cell. • And replaced it with their man-made chromosome. People say that the headlines saying that a man-made cell are misleading. Explain why. © Snapshot Science, 2010 Activity How was the first man-made cell created? Step 5: The new cell was left to reproduce. • • It did reproduce. What does this prove about the cell? How could the scientists prove that the new cells contain their man-made DNA? © Snapshot Science, 2010