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Recognition by innate immunity
What is recognized by innate cells?
Which molecules may serve as danger signals and which receptors can recognize these signals?
How the drosophila and the human toll-receptor signaling is different?
What are the ligands of the intracellular and the cell surface TLR receptors?
Whih are the two major signaling pathways activated by TLRs?
Based on which characteristics are NOD-like receptors devided into subgroups?
In which cellular processes are these receptors involved?
What is an inflammosome?
Which are cytosolic nucleic-acid recognizing receptors?
What is their response when they detect foreign nucleic acid?
Where are they located and what do they recognized? :
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N-formil-met-leu-phe receptors
DC-SIGN, Dectin, mannóz receptorok
Scavenger receptorok
Which are extracellular PRR-s and what is their function?
Antiviral state
How do human cells sense that they become infected with a virus?
How do type-I IFNs regulate the immune response.
List the major functions of NK cells! what type of receptors do they express?
What is prerequisite of NK cell activation?
What is the ligand of the CD94:NKG2A receptor?
Which part of the Az MHC-I-peptide complex is bound by the TCR or the KIR?
What happens during education of NK-cells in the bone?
Actute inflammation
What is the trigger and where does it occur within the host?
Describe the most important vascular and cellular events.
which are the major symptoms why do they develop?
What is the fate of leukocytes and fluids that leave circulation??
Which are the most important mediators?
Describe extravasation of the neutrophils!
!what is their local and systemic effects?
What is puss?
Deacribe the acute phase response which are the major proteins involved? What is their function?
What is the order of sequence of the events during acute inflammation?
The complement system (CS) . Characteristics and function.
What are the major pathways and components of the CS., ?
Which are the main functions of complement?
which molecules take part in the initiation/recognition, in the the early and in the late phase? Milyen
molekulák és hogyan vesznek részt a komplement aktiváció iniciációs, korai és késői fázisában?
Why the host cells are usually unharmed by the immune system?
Give examples of the negative regulation in the CS. How do they work?
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C1inh
H-factor
C4BP
DAF
MCP
CD59
What are the consequences of congenital C3-deficiency? ?
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severe bacterial infection with pyogenic (puss forming) bacteria etc..
What are the consequences of deficiency of the proteins classical pathway? (rather immune complex
diseseases develop)
What are the consequences of deficiency ot the terminal components (C7-9) (Nesseria)
Mi a terminális komponensek hiányának következménye? (Nesseria fertőzésék)
What are the consequences of deficiencies affecting inhibitors the CS?
C1Inh ödémák, HANE
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factor I , H-faktor
CD59