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V-11 The effects of dobutamine-ivabradine combination and omecamtiv treatment on the diastolic in a porcine model of acute ischemic heart failure Leif Rønning DVM, Jens Petter Bakkehaug MD, Lars Rødland Stud.med., Anders Benjamin Kildal MD PhD, Truls Myrmel MD PhD, Ole-Jakob How PhD Cardiovascular Research Group, Department of Medical Biology Faculty of Health Sciences, UiT The Arctic University of Norway V-11 Background and hypothesis Acute diastolic failure in ischemic cardiogenic shock is associated with a grave prognosis. Improving SV is beneficial to these patients, but they already have a elevated heart rates. There is a rationale for finding an inotropic treatment without further elevating the heart rate. Hypothesis: The combined treatment with the catecholamine Dobutamine and the sinus node If-channel inhibitor Ivabradine exerts different lusitropic effects on early diastole in acute heart failure than the treatment with the myosin activator omecamtiv. V-11 Methods Anesthetized pigs were subjected to left ventricular ischemia by injection of polystyrene microspheres into the coronary main stem (n=12). The animals were then randomized to receive omecamtiv (OM) (bolus 0.75 mg/kg plus 0.5 mg/kg/h) (n=6) or a combination of dobutamine (infusion 5 µg/kg/min) and ivabradine (bolus 0.29 ±0.16 mg/kg) (D+I) (n=6). Assessments were done at intrinsic HR, and pacing at 120 and 160 BPM V-11 Results No significant change in HR in any of the treatment groups V-11 Results V-11 Conclusion The partially restored diastolic suction and lusitropic effect of combined dobutamine-ivabradine treatment is important to restore cardiac output and stroke volume in acute ischemic heart failure. This effect was not observed in the omecamtiv-treated animals.