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Supplemental Table 1. Serious cardiac outcome definitions. a Outcome Death Myocardial Infarction (MI) Heart Failure (HF) Serious Arrhythmia Refractory Ischemic Cardiac Pain a Definition either cardiovascular or noncardiovascular indicated by biochemical markers of myocardial necrosis (e.g., a typical rise and gradual fall of cTnI concentrations), along with at least 1 of the following: ischemic symptoms, development of pathologic Q waves on the electrocardiogram or changes indicative of ischemia, coronary artery intervention, or pathologic findings of an acute MI as indicated by any 2 of these 3 criteria: radiograph evidence of HF; clinical signs and symptoms of HF; and/or administration of a diuretic ventricular fibrillation, sustained ventricular tachycardia, asystole, electromechanical dissociation, supraventricular tachycardia, atrial fibrillation, sinus bradycardia, or secondor third-degree heart block, along with administration of cardioversion, atropine, an anti-arrhythmic, rate-slowing or sympathomimetic drug, or a temporary pacemaker defined as recurrent ischemic symptoms lasting 15 minutes or more, along with documented electrocardiographic changes indicative of ischemia or leading to a referral for an additional intervention Adapted from Worster A, Devereaux PJ, Heels-Ansdell D, Guyatt GH, Opie J, Mookadam F, et al. Capability of ischemia-modified albumin to predict serious cardiac outcomes in the short term among patients with potential acute coronary syndrome. CMAJ 2005;172:1685-90.