Download dental second assessment

Libyan International Medical University
Faculty of Dentistry
Pharmacology 2nd assessment
Date : 16/5/2010
Time : 60 min.
Name :……………………………………………
Number:……………………………..
Q1. ENCIRCLE ONLY ONE CORRECT ANSWER :
(2MARKS EACH)
1. Drug metabolism leads to :
a. Decreased polarity .
b. Enhanced excretion .
c. Increased activity of most drugs .
d. Increased concentration in C.S.F
2. Which of the following is not true regarding drug biotransformation :
a. Oxidative stress decreases the formation of free radicals .
b. The mixed function oxidase system is the major catalyst.
c. May occur in the plasma.
d. Phase I enzyme are located in the S.ER .
3. The following drugs can form active metabolites except :
a. Warfarin.
b. Enalapril.
c. L-dopa.
d. Talampicillin.
4. All the following are phase 1 metabolic reactions except :
a. Hydrolosis.
b. Sulphation.
c. Oxidation.
d. Reduction.
5. Drug conjugation :
a. Is non synthetic process.
b. Decreases elimination of drugs.
c. Occurs in the mitochondria.
d. Is a detoxification mechanism.
6. Which of the following is the most common conjugation reactions :
a. Methylation.
b. Glucuronidation.
c. Conjugation with amino acids.
d. Glutathione conjugation.
7. All the following factors affect biotransformation of drugs except :
a. Genetic polymorphism.
b. Enzyme induction.
c. Entro hepatic cycle.
d. Enzyme inhibition.
8. Which of the following mechanism of drug excretion is PH dependent :
a. Glomerular filatration.
b. Biliary excretion .
c. Active tubular reabsorption.
d. Passive tubular reabsorption.
9. Characteristics of enzyme induction include the following except :
a. Irreversible process .
b. Increases weight of liver.
c. Takes long time to occur.
d. Inducing agents are specific for a given cytochrome P450.
10. Which of the following drugs is an enzyme inhibitor:
a. Erythromycin.
b. Rifampin.
c. Phenobarbtion.
d. Carbamazepine.
11. Which of the following pairs of drugs is an example of physiological antagonism :
a. Propranolol and isoprenaline .
b. Atropine and acetyl choline.
c. Protamine sulphate and heparin.
d. Histamine and adrenaline.
12. Which of the following drugs acts by blocking sodium channels ?
a. ASA.
b. Desferroxamine.
c. Lidocaine.
d. Physostigmine.
13. All the following are idiosyncratic adverse effects of drugs except :
a. Peripheral neuritis due to isoniazid.
b. Malignant hyperthermia with halothane.
c. Discclaration of teeth due to tetracycline.
d. Respiratory apnea with succinyl cholne.
14. Which of the following is a measure of potency ?
a. LD50.
b. Emax.
c. ED50.
1
d. t 2 .
15. All the following drugs may lead to addiction except :
a. Morphine.
b. Barbiturates.
c. Warfarin.
d. Alcohol.
Q2. EXPLAIN WHY
1. Chloramphenicol is contraindicated in neonates ?
2. Rifampin attenuates the effectiveness of oral contraceptive ?
3. Probenecid increases the duration of action of penicillin ?
4. Efficacy is more important clinically than potency ?
5. Metabotropic receptors are slower than ionotropic receptors ?
(3 MARKS EACH )
Q3. TRUE OR FALSE
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
(1/2 MARK EACH)
Reduction is the most common phase 1 reaction.(
)
Phenobarbitone is an enzyme inhibitor.(
)
Autoinduction leads to tolerance.(
)
Metabolites of phase 2 are less polar than phase 1.(
)
Log dose response curve is hyperbolic in shape.(
)
A partial against has affinity and zero efficacy.(
)
GABAA receptors are metabotropic receptors.(
)
Atropine is a non competitive antagonist at muscarinic receptors.(
Hypersensitivity is a dose dependant and predictable side effect.(
Insulin receptor is a nuclear receptor. (
)
GOOD LUCK
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