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Transcript
Lectures on Computational Biology EFSS II National DongHua University Hualien, 2002 July 1-5 HC Lee Computational Biology Lab Center for Complex Systems & Biophysics National Central University What is Computational Biology? The use of computational techniques to model biological systems at various levels of complexity - atomic, metabolic, cellular and pathologic. Central dogma for molecular biology DNA RNA Protein DNA Yeast alanyl transfer RNA Standard Genetic Code Amino acid codes Name, 3-letter and single-letter codes Aspartic Acid Phenylanine Alanine Histidine Lysine Methionine Proline Arginine Threonine Tryptophan Asp Phe Ala His Lys Met Pro Arg Thr Trp D F A H K M P R T W Glutamic Acid Glycine Cystine Isoleucine Leucine Asparagine Glutamine Serine Valine Tyrosine Glu Gly Cys Ile Leu Asn Gln Ser Val Tyr E G C I L N Q S V Y A protein cartoon Sperm whale myoglobin (1MBN) The Protein Folding Problem Central paradigm for Bioinformatics Central Paradigm Lecture 1 Sequence Alignment Lecture 2 Hidden Markov Model Lecture 3 Molecular Evolution and Phylogeny Lecture 4 Microarray & Analysis
