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Supplementary MBBS I (First) Professional Examination 2014-15 Course Code: MBS103 Paper ID: S322208 Biochemistry -I Time: 2 Hours 40 Minutes Max Marks: 40 Note: Attempt all questions. Draw proper diagrams to support your answer. Part ‘B’ 1. Define and classify lipids with examples. Discuss digestion of lipids. (10) 2. a) b) Write short notes on the following: Significance of pentose phosphate pathway Ketone bodies (5x2=10) 3. Define isoenzymes. Discuss the role of isoenzymes in clinical diagnosis with suitable examples. (10) 4. Differentiate between: B-DNA and Z-DNA Starch and glycogen a) b) (5x2=10) Supplementary MBBS I (First) Professional Examination 2014-15 Roll No. Student’s Name Student’s Signature Invigilator’s Signature Course Code:MBS103 Paper ID: S322208 Biochemistry - I Part ‘A’ Time: 20 Minutes Max Marks: 10 Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes. 2. Please tick (√) correct one only. Cutting, overwriting or any other marking are not allowed. 3. For answering please use Ball- pen only. Q.1 Following is not a branched chain amino acid: a) Valine b) Leucine c) Isoleucine d) Lysine Q.6 Hyperbolic oxygen dissociation curve is a property of: a) Hemoglobin b) Myoglobin c) Methemoglobin d) Carboxy-hemoglobin Q.2 Proteins targeted for destruction eukaryotes are covalently linked to: a. Clathrin b. Pepsin c. Laminin d. Ubiquitin Q.7 Secretion of gastric HCl is stimulated by: a) Secretin b) Pancreozymin c) Histamine d) Melatonin Q.8 Q.3 Triple helix is found in: a) Cystine b) Collagen c) Pectin d) DNA Which body: a) b) c) d) in Q.4 Cyanide is toxic because it: a) Inhibits cytochrome C oxidase b) Forms cyanmethaemoglobin c) Inhibits ATP carrier in mitochondria d) Inhibits Na+-K+ ATPase Q.5 All is true about glutathione except: a) It is a tripeptide b) It converts hemoglobin to methemoglobin c) It conjugates xenobiotics d) It scavenges free radicals and superoxide ions of the following is not a ketone Acetoacetate Acetoacetyl CoA 3-Hydroxybutyrate Acetone Q.9 All of the following are mitochondrial reactions except: a) Transamination b) Ketone body formation c) Beta oxidation of fatty acids d) Krebs cycle Q.10 Absence of carnitine will affect: a) Fatty acid synthesis b) Fatty acid oxidation c) Creatinine formation d) Urea synthesis P.T.O. Q.11 Q.12 Hexose monophosphate responsible for production of: a) Hexose b) NADH c) Ribose d) ATP shunt is Phosphorylation of glycogen synthase: a) Increases synthesis of glycogen b) Decreases synthesis of glycogen c) Has no effect on glycogen synthesis d) Inhibits glycogenolysis Q.13 UDP is a carrier of: a) Monosaccharides b) Fatty acids c) Nucleic acids d) Amino acids Q.14 Chylomicrons are formed within: a) Intestinal lumen b) Enterocytes c) Adipocytes d) Lymphatic vessels Q.15 Activity of amylase cannot convert starch into: a) Maltotriose b) Limit dextrin c) Maltose d) Glucose Q.16 Cytochrome p450 is present in: a) Mitochondria b) Golgi complex c) Endoplasmic reticulum d) Lysosome Q.17 Glucose 6-phosphate deficiency leads to: a) Pernicious anemia b) Hemolytic anemia c) Glycogen storage disease d) Galactosemia Q.18 Maple syrup urine disease results from defect in metabolism of: a) Branched chain amino acids b) Acidic amino acids c) Basic amino acids d) Imino acid Q.19 Blood level of free fatty acids increases in following: a) b) c) d) Q.20 High fat diet Diet rich in carbohydrates Starvation Intake of cholesterol-lowering drugs Lipoic acid is a component of: a) Lipoproteins b) Fatty acid synthetase complex c) Pyruvate dehydrogenase complex d) Electron transport chain