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Transcript
Integrative genomic analysis of lung cancer cell lines
Lung cancer is the leading cause of cancer mortality worldwide. Genetic
analyses and gene expression profiling of human lung tumors identified several
aberrant signaling pathways involved in the lung cancers. Genetic alterations in
cancers have been linked with response to targeted therapeutics and tumor
metastasis on activated oncogenic signaling pathways. We collected 44 lung
cancer cell lines with variety of histology patterns, EGFR status and invasion
ability. We generated several genomics data such as DNA copy number variation
and Next-Generation-Sequencing Cancer Panel. By correlating with the lung
cancer cell genomic profiles, genetic predictors of invasion ability were available;
but they did not connect well with clinical outcomes. Because metastasis is
another essential factor of cancer mortality, we conducted an invasion assay to
obtain the phenotype information of lung cancer cell lines. After a series of
statistical analysis, we obtained a set of invasion-associated genes. We validated
the signature’s performance with early stage lung cancer cohort. Our data light
on the complex genetic involvement in the molecular mechanisms of tumor
invasion and growth inhibition.