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Integrative genomic analysis of lung cancer cell lines Lung cancer is the leading cause of cancer mortality worldwide. Genetic analyses and gene expression profiling of human lung tumors identified several aberrant signaling pathways involved in the lung cancers. Genetic alterations in cancers have been linked with response to targeted therapeutics and tumor metastasis on activated oncogenic signaling pathways. We collected 44 lung cancer cell lines with variety of histology patterns, EGFR status and invasion ability. We generated several genomics data such as DNA copy number variation and Next-Generation-Sequencing Cancer Panel. By correlating with the lung cancer cell genomic profiles, genetic predictors of invasion ability were available; but they did not connect well with clinical outcomes. Because metastasis is another essential factor of cancer mortality, we conducted an invasion assay to obtain the phenotype information of lung cancer cell lines. After a series of statistical analysis, we obtained a set of invasion-associated genes. We validated the signature’s performance with early stage lung cancer cohort. Our data light on the complex genetic involvement in the molecular mechanisms of tumor invasion and growth inhibition.