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Rosemilande Pierre 03.06 Mutations Analyzing the graph Describe how mutation and sexual reproduction can leads to genetic variation in a population Mutation leads to genetic variation, usually, when there is replacement of one existing nucleotide with another and that leads to a heritable change in a certain phenotype. Which appears to be more dangerous: The BRCI OR BRC2 Mutation? There’s a somewhat higher risk for breast and ovarian cancer with BRCA1 mutations than with BRCA2 mutations but breast cancer in males is associated with BRCA2 mutation. In my opinions, they are equally bad and I have yet to come across a published article that convinces me otherwise Analyze a woman’s risk of dying of cancer if she carries mutated BRCI Risk of dying depends on what type of cancer is present. It can be very treatable, or the patient who tests positive for having the mutation might never develop the cancer. Explain how breast-cancer genes are still present in the population despite cancer-related surgeries and deaths. Rosemilande Pierre 03.06 Mutations How are breast cancer genes are still present in the population, despite cancer related surgeries and deaths? For a genetic mutation to be passed along to your offspring the mutation must exist in your reproductive cells sperm and or egg. These are not removed by breast cancer surgery. Most cases of breast cancer occur after the woman has had children, so the gene, if it is present, is passed on to her children before she knows she knows that she as or will get cancer. She might also be a carrier spreading the mutation, but she herself is not affected.