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Acquired Immunity
Hugh B. Fackrell
filename : Kuby 01B7
4/29/2017
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Acquired Immunity: Outline
Acquired vs Innate Immunity
 Functions of Acquired Immunity
 Humoral Immunity: antibody
 Cell Mediated Immunity
 Role of Macrophages
 Regulation of Immunity

 Next
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Acquired Immunity: Definitions
Acquired Immunity
 Antigen
 Immunogen
 Humoral Immunity
 Cell Mediated Immunity

 Next
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Acquired Immunity: Objectives
Define the following terms: Antigen,
immunogen, acquired immunity, humoral
immunity, cell mediated immunity
 Identify the cells of the acquired immune
response from light or electron micrographs
 Identify the functions of the cells of the acquired
immune reponse
 Next
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Acquired Immunity

Definition
 Acquired
immunity( AKA adaptive immunity)
is an altered reactivity to a specific compound
after exposure to that compound

Characteristics
 Specificity
 Memory
 Next
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Acquired Immunity
Important Features


The altered reactivity will not be to all
compounds, just those compounds to which
the animal has been exposed
The animal has a heightened specific response
on second and subsequent exposures because the
body ” remembers” previous contacts
 Next
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Functions of Acquired Immunity
Discriminate between self and non self for:
 Defense
 destruction

Homeostasis
 removal

of foreign molecules
of dead or damaged cells
Surveillance
 control
of mutant or cancer cells
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Acquired Immunity has
Two Forms

Humoral Immunity
 lymphocytes
react INDIRECTLY on non self
molecules via antibodies

Cell Mediated Immunity
 Lymphocytes
act DIRECTLY on the non self
molecules
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Lymphocytes
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Immunogen vs Antigen
ANTIGEN: combines with the
products of an immune response
IMMUNOGEN:
triggers immunity
and
combines with products
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Antigen: interaction
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Remember
Immunogenicity is not an inherent
characteristic of a molecule
 Immunogen MUST first be recognized
as foreign by the body

 Next
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Adaptive vs Innate Immunity
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Primary vs Secondary Responses
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Humoral Immunity
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Antibodies Distinguish Between

Diseases
 measles

& mumps
Macromolecules
 proteins,

Molecules
 amino

complex carbohydrates
acids, sugars
Submolecular Structures
 D&
L isomers; ortho, meta, para positions
 Next
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B cell blasts
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B Cell Transformation
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Clonal Selection: B cells
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Immunglobulin on B cells
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Plasma cell function
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Antibody: a Flexible mediator
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Plasma cell: function
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Complement functions
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Cell Mediated Immunity
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T cell blasts
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T cell blasts: structure
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T cells
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Cell mediated clonal selection
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T cell transformation
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T cells ANAE stain
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Role of Macrophages
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Monocyte
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Monocyte structure
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Macrophage Activation products
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Macrophages & T cells
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T cells interacting with
Macrophage
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Macrophage mediatiors:
CD14 receptor
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Macrophage mediators:
CD14 & LPS receptors
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Endotoxin induction of
Macrophage mediators:
direct induction
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Oponsization: mechanisms
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Regulation of Immunity
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Range of immune responses
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Antigen Processing
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Cellular interactions during the
humoral response
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A Complete Immune Response

Lymphocytes
B
cells
 T cells

Macrophages
 critical

accessory cells
Complement
 combines
with antibody to enhance destruction
 Next
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White Blood Cells
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Adverse effects of Immunity
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The End
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Acquired Immunity:
Questions
How does clonal selection contribute to memory
in the immune response?
 Name three feature of a secondary immune
response that make it different from a primary
immune response.
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Questions(1)

Interleukin 2 is a nonspecific growth factor
that stimulates the growth of TH cells
during the immune response. In view of this
nonspecificity of IL-2, what mechanism
assures that only TH cells specific for a
given antigen proliferate and that all other
TH cells do not proliferate
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Questions (2)

Antigen presenting cells play a role in both
humoral and cell mediated immune
responses
 Name
three type af antigen presenting cells
 Which class of MHC molecules are expressed
on the membrane of antigen presenting cells?
 Which lymphocytes interact eith antigen
presenting cells?
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