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The cardiac cycle Candidates should know and understand: Pressure and volume changes and associated valve movements during the cardiac cycle. Cardiac output as the product of heart rate and stroke volume. Blood Flow Artery Ventricle Vein Atrium Blood Flow Vein Atrium Walls of atrium contract (systole) Ventricle Artery Walls of ventricles contract (systole), and atria relax (diastole) How is heart beat controlled? • Automatic (Myogenic) • Heart has its own inbuilt pacemaker – sino-atrial node (SAN) • Group of cells in wall of right atrium that produce their own nerve impulses at regular intervals • Cause atria, then ventricles to contract as the impulses spread out – domino effect • Blood at a low pressure in the veins flows into the atria. This increases the pressure inside the empty atria as they fill. Some of the blood trickles through the open atrioventricular valves into the relaxed ventricles below. • When the atria are full, they go into atrial systole (contraction), and blood is pushed through the valves into the ventricles. The pressure in the atria is increased due to the contractions and the pressure is increasing in the ventricles as they fill with blood. • When the atria contract, blood cannot flow back into the veins because the pressure of the blood pushes on the valves in the veins to shut them. • After a short delay the ventricles contract from the base upwards. The pressure inside the ventricles increases due to the ventricular systole. As the pressure increases to a higher level than the pressure in the atria, blood pushes against the atrioventricular valves, shutting them (the first heart sound) and preventing backflow. • The semilunar valves open under the pressure and blood leaves the heart through the artery. • The ventricles relax - ventricular diastole - and the semilunar valves snap shut behind the blood (the second heart sound). Which side of the heart is the graph showing? How can you tell? What would the difference be if it was the other side? How long is one heart beat? Cardiac Output • Definition: the volume of blood pumped by one ventricle in one minute. • Units: dm3min-1 • Depends on: Heart rate and stroke volume (volume of blood pumped per beat) Cardiac output = heart rate x stroke volume