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Title Basic Pharmacology Code PY134 (formerly CF104) Level 4 Credit rating 10 credits Pre-requisites Essential Cell Biology and Biochemistry Type Standard core choice module delivered over 13 weeks Aims To provide a basic understanding of pharmacological principles and their application to the clinical situation. Learning outcomes At the end of this module, students should be able to: • • • • Content appreciate the cellular changes which can be induced by drugs. demonstrate a knowledge, in quantitative terms of the relationship between a drug and its response. appreciate how drugs are absorbed, metabolised, distributed and excreted. understand the mechanism of action of drugs used to treat a variety of clinical conditions. Introduction to the interrelationships between physiology, pharmacology and pathology. An overview of the different sources of drugs, methods of establishing pharmacological and toxicological profiles and the concepts of pre-clinical and clinical trials. (5 hours) Principles of drug actions and effects: the mechanisms of drug action, the dose-response relationship; competitive and non-competitive antagonism. The concepts of dependence, addiction, tolerance and withdrawal effects; basic human pharmacokinetics and drug metabolism. (5 hours) Drugs acting directly on DNA and protein synthesis: therapeutic uses and adverse effects of those anticancer drugs acting by prevention of DNA replication. The use of drugs which influence protein synthesis, for example steroids. (2 hours) Therapeutic uses of drugs which alter enzyme activity: consideration of the mechanisms of action and therapeutic uses of drugs which alter enzyme activity such as angiotensin-converting enzyme inhibitors, monoamine oxidase inhibitors and dihydrofolate reductase inhibitors. (3 hours) The interaction of drugs with ion channels: the mechanism of action and therapeutic uses of drugs which act directly on ion channels, for example local anaesthetics, anti-arrhythmic agents, calcium channel blockers and diuretics (3 hours) Drugs acting via receptors and second messengers: an overview of the potential therapeutic uses and adverse effects of drugs which either stimulate or antagonise receptors for endogenous transmitters such as acetylcholine. noradrenaline, histamine and serotonin. (6 hours) 1 Drugs acting on the brain: consolidation of the foregoing lectures by illustrating the mechanisms of action of common drugs of abuse. Drug dependence and substance abuse. (2 hours) Teaching and learning strategies 100 hours in total, normally comprising 26 hours contact time, 44 hours guided study and 30 hours independent study assessment time. Learning support Current editions of: Brody, T M et al, Human Pharmacology: Molecular to Clinical, Mosby Gard, P R, Human Pharmacology, Taylor and Francis Foster, R W, Basic Pharmacology, Butterworth-Heinemann Neal, M J, Medical Pharmacology at a Glance, Blackwell Assessment One MCQ phase test (40%) and an end of module MCQ exam (60%). The pass mark for each component is 50%. Brief description of module The module builds on the students' knowledge of cellular and molecular biology to explain the mechanisms by which drugs may alter cellular activity and function and can thus be used to correct, or relieve the symptoms of, disease processes. Examples of common medicines and diseases are used to illustrate mechanism of drug action and adverse drug effects. Area Examination Board Pharmacology and Therapeutics Module authors Dr Chatterjee, Drs P R Gard, Dr A Jackson Semester offered 2 Date of first approval May 2002 Date of last revision Sept 2007 (3a: ex ex updated Jan 08) Date of approval of this version Nov 2008 (MPharm removed as compulsory) Version number 3b Replacement for previous Module BY222, PY125 Code changed from CF104 September 2006 Course(s) for which module is acceptable and status in course Compulsory for Biomedical Sciences, Pharmaceutical and Chemical Sciences Optional for Biological Sciences School home School of Pharmacy and Biomolecular Sciences External examiner Professor J Neill 2