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Pharmacology • Science that studies interactions of drugs with organism on different levels (subcellular, cellular, organ, systemic) Studies: - relationship between chemical structure and biologic activity - site of effect localisation - mechanism of action - fate of drug in organism - evaluation of relationship between dose and biologic effect Clinical pharmacology • • - is the science of drugs and clinical use of drugs branches: pharmacodynamics pharmacokinetics rational prescribing adverse drug effects drug interactions toxicology drug development Pharmacogenetics • study of genetic variation which cause different response to drugs • is taking into consideration one or only a few genes • e.g. of genetic variation: “slow and fast acetylators“ (variation in the Nacetyltransferase gene) Pharmacovigilance • science of collecting, monitoring and evaluating information of the adverse effects of medications, biological products, herbalism and other medicines • from Greek pharmacon = drug Latin vigilare = to keep alert Pharmacoeconomics • study that evaluates the cost and effects of a drug or drug therapy • examples of pharmacoeconomic evaluation types: - cost – benefit analysis - cost – minimization analysis