Download Annexure `CD – 01` FORMAT FOR COURSE CURRICULUM L T P/S

Annexure ‘CD – 01’
FORMAT FOR COURSE CURRICULUM
Course Title: ADVANCES IN PHARMACOLOGY RESEARCH
Credit Units: 04
Course Level:
Ph. D.
Course Code:
L
T
P/S
SW/F
W
3
1
-
-
TOTAL
CREDIT
UNITS
4
Course Objectives: Study of Pharmacological principles and tools for successful completion of research projects/proposals.
Pre-requisites: In-depth knowledge of Pharmacology
Student learning objectives:
1. Understanding the basic concepts of research proposal
2. Study of advancement in tools and techniques related to Pharmacology
3. Students will get in-depth knowledge of Novel Target Sites and duggable targets as well as target organ toxicity
Course Contents/Syllabus:
Weightage (%)
Module I
Pharmacology Research Proposal
10
Introduction, Sources and types of funding, Types of proposals, Necessary ingredients in an application, Fatal flaws and
common problems, Budgets, Resources, Collaborators, Reviewing and Acceptance proposal, Responsible conduct,
confidentiality and conflicts of interest. Role of search engines and literature for successful research proposal
Module II
Advanced drug discovery tools and techniques
Computer added drug design (CADD), Electrophoresis and blotting techniques, DNA sequencing techniques, Flow
Cytometry, Genomics, High throughput screening (HTS), Immunohistochemistry, Liquid chromatography mass
30
spectrometry (LC-MS), Microarray, Microscopy, Patch clamp Technique,
Proteomics, Radio ligand binding)
Polymerase chain reaction (PCR),
Module III
Systems & Computational Pharmacology
20
Systems-level understanding of human disease. Computational pharmacology: analysis of large genomic and proteomic
data sets; to design novel molecular tools to probe and perturb cellular function, quantitative image analysis and develop
predictive models of complex cellular processes.
Module IV
Novel Target Sites
20
Physiological functions, pharmacological implications, and therapeutic potential of the following target sites: Rho
kinase (ROCK), Phosphoinositide 3-kinase (PI3K), Akt (Protein kinase B), Caspases, Poly (ADP-ribose) polymerase
(PARP), Peroxisome proliferator activator receptors (PPAR), AMP activated protein kinases, Protein kinases,
Phosphodiesterases
Module V
Principles of Toxicology and Target Organ Toxicity
Principles of Toxicology: Introduction and applications in preclinical research; Target Organ Toxicity: Specific
structural changes in target organs including the liver, lung and kidney, and the endocrine, nervous, reproductive and
immune systems with emphasis to understand the mechanism(s) for the adverse responses of specific agents at a given
target site
Pedagogy for Course Delivery: PowerPoint and whiteboard based class learning
20
Assessment/ Examination Scheme:
Theory L/T (%)
Lab/Practical/Studio (%)
Total
100
0
100
Theory Assessment (L&T):
Continuous Assessment/Internal Assessment
Components (Drop
down)
Weightage (%)
End Term
Examination
Seminar/Presentations
Viva
Attendance
20
05
05
Text Reading and References:
BOOKS RECOMMENDED
1. Annual Review of Pharmacology and Toxicology
2. Annual Review of Medicine
3. Trends in Pharmacological Sciences
4. Advances in Pharmacology
5. Trends in Biotechnology
6. Advances in Drug Therapy
7. Drug Discovery Today
Additional Reading:
Any other Study Material: Research Journals and related information on internet
70