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NLM Informatics Training Conference - 2016 ABSTRACT INSTRUCTIONS Instructions for Plenary/Focus Session/Poster Abstracts Due: March 7, 2016 – 5:00 p.m. EST 1. Submissions for each presentation should consist of a title, an author list, and an abstract (together on one page). Example is attached. 2. The title should not exceed 75 characters. 3. The first author will be the presenter at the meeting. He/she must be a trainee currently supported by the NLM, CDC or VA. Up to four additional authors may be listed. Authors should be listed by first name, middle initial (optional), last name, and University or Institution—with authors separated by commas and no period after the middle initial. Do not include academic degrees in the author lists. (In special cases, trainees who were formerly, but are not currently, supported by NLM may present at the meeting. In such cases, contact Dr. Florance for clearance before submitting). 4. The abstract should not exceed 200 words. 4a. Below the abstract, indicate whether the work to be presented is proposed for Plenary, Focus or Poster session. 4b. Below the abstract, indicate which of the four training tracks is appropriate: Health care informatics; Bioinformatics/computational biology; Clinical research translational informatics; Public health informatics 5. Each submission {Together: title, author list, abstract} should be attached as a separate Microsoft Word document. Example is included below. 6. Submit by e-mail to Christine Ireland ([email protected]) by March 7, 2016, 5:00 p.m. EST. All submissions should come from the program director or his/her administrative designee (preferably all in the same e-mail), and not directly from the trainees. Additional Poster Instructions Poster dimensions should be 3’ (h) x 5’ (w). Poster presenters should arrive at the meeting at least half an hour early and check in at the front desk where they will be assigned a number for their poster, with the coordinating number on their nametag. Power Point Presentations for Plenary or Focus Sessions In order to ensure that all presentations are loaded onto the conference room laptops prior to the meeting, please have all trainees submit their final presentations electronically (in Power Point format) to Christine Ireland at [email protected] by COB June 16, 2016. Backup files should also be brought to the meeting on USB format. (EXAMPLE ABSTRACT) Computational Modeling of Genome-Wide Targeting of Somatic Hypermutation Authors: Jamie L Duke, Man Liu, David G Schatz, Steven H Kleinstein, Yale University Abstract: Activation Induced Cytidine Deaminase (AID) is required for somatic hypermutation (SHM) of the B cell receptor during normal immune responses. Mistargeting of AID can lead to mutation of non-immunoglobulin genes and has been proposed as a contributing factor of tumorigenesis. Through large-scale sequencing, we have shown AID targets a large fraction of expressed genes in normal B cells and results further suggests the B cell genome is protected by two distinct processes: targeting of AID to particular genes and gene-specific targeting of highfidelity repair to AID-induced lesions1. From these experiments, we compiled a dataset of 26 Mb of sequence from 180 genes in wild-type and various knockout mouse models. Each gene exhibits a unique mutation pattern and genomic context offering and unprecedented opportunity to address several questions concerning AID targeting and mechanism of action. Our analysis includes a comparison of targeting mechanisms for SHM in non-immunoglobulin genes versus immunoglobulin genes, and an examination of the potential functional consequences of aberrant SHM. Additionally, models have been developed to quantitatively distinguish between genes which are strongly and weakly targeted by AID and SHM with current results suggesting the mechanism of AID targeting is at least partially shared between immunoglobulin and non-immunoglobulin genes. Research Stage: Completed Proposed for: Plenary or Focus Session; Poster Research Theme: Bioinformatics/computational biology E-mail of First Author: _________________________