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Transcript
I’m Millie, one of the BBC school reporters, and I’ve been fascinated to learn that our cells can
stay active, even when we’re dead. But, why and how? Read on to find out…
Recent scientific studies have shown that when you die there are actually cells inside you that are still alive! The
discovery that many genes are still working up to 48 hours after death has implications for organ transplants,
forensics and our very definition of death. Why and how?
Anna Williams, in New Scientist, writes: When a doctor declares a
person dead, some of their body may still be alive and kicking – at
least for a day or two. New evidence in animals suggests that
many genes go on working for up to 48 hours after the lights have
gone out.
This hustle and bustle has been seen in mice and zebrafish, but
there are hints that genes are also active for some time in
deceased humans. This discovery could have implications for the
safety of organ transplants as well as help pathologists pinpoint a
time of death more precisely, perhaps to within minutes of the
event.
Hundreds of genes with different functions “woke up” immediately after death. These included fetal development
genes that usually turn off after birth, as well as genes that have previously been associated with cancer.
Their activity peaked about 24 hours after death [and] a similar process might occur in humans.
While the precise steps are not yet defined, scientists do not believe the process is random. Different cell types
have different life spans, generation times and resilience to extreme stress. Some stem cells remain alive and
attempt to repair themselves after death, even including embryonic stem cells.
The research also raises important questions about our definition of
death – normally accepted as the cessation of a heartbeat, brain activity
and breathing. If genes can be active up to 48 hours after death, is the
person technically still alive at that point? “Clearly, studying death will
provide new information on the biology of life,” Dr Peter Noble of the
University of Washington and Alabama State University and author of
the study told the MailOnline.
But the study does not mean life could be brought back after death: 'Our research does not provide evidence
that organisms can be brought back to life,' says Noble. 'However, discovering the 'how and why' gene
transcripts increase in abundance in organismal death might provide valuable insights into cancer.’