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Last data updates: 06 January 2011 Ma, Q.P., Zhou, Y., Yu, Y.X. and Han, J.S. (1992), Electroacupuncture accelerated the expression of c-fos protooncogene in serotonergic neurons of nucleus raphe dorsalis. International Journal of Neuroscience, 67 (1-4), 111-117. Document type: Note Language: English Cited references: 20 Time cited: 7 Times self cited: 0 Abstract: It has been proposed that the FOS protein encoded by c-fos protooncogene functions as a nuclear ''third messenger'' molecule that couples short-term extracellular signals to long-term alterations in cell function, by regulating the expression of specific target genes. In the present study, immunocytochemical double staining technique was used to investigate the effects of electroacupuncture on the expression of c-fos oncogene in the serotonergic neurons in the nucleus raphe dorsalis (NRD) that has been known to play an important role in the endogenous analgesic system of the brain. The number of FOS positive serotonergic cells in the NRD increased significantly after the electroacupuncture stimulation. These results indicate that electroacupuncture can activate central serotonergic neurons at gene expression level. Author Keywords: Electroacupuncture; Serotonin; C-Fos Protooncogene; Nucleus Raphe Dorsalis Keywords Plus: Nerve Growth-Factor; Analgesia; Accumbens; Proteins; Pathway; Complex; Loop Addresses: 1. Beijing Med Univ, Dept Physiol, Beijing 100083, Peoples R China 1. 2. 3. Song, C., Halbreich, U., Han, C., Leonard, B.E. and Luo, H. (2009), Imbalance between Proand Anti-inflammatory Cytokines, and between Th1 and Th2 Cytokines in Depressed Patients: The Effect of Electroacupuncture or Fluoxetine Treatment. Pharmacopsychiatry, 42 (5), 182-188. Santos, J.G., Kawano, F., Nishida, M.M., Yamamura, Y., Mello, L.E. and Tabosa, A. (2008), Antidepressive-like effects of electroacupuncture in rats. Physiology & Behavior, 93 (1-2), 155-159. Pohl, A. and Nordin, C. (2002), Clinical and biochemical observations during treatment of depression with electroacupuncture: a pilot study. Human Psychopharmacology-Clinical and 4. Experimental, 17 (7), 345-348. Kwon, Y.B., Kang, M.S., Son, S.S., Kim, J.T., Lee, Y.H., Han, H.J. and Lee, J.H. (2000), Different frequencies of electroacupuncture modified the cellular activity of serotonergic 5. neurons in brainstem. American Journal of Chinese Medicine, 28 (3-4), 435-441. Russell, A.L. and McCarty, M.F. (2000), DL-phenylalanine markedly potentiates opiate analgesia - an example of nutrient/pharmaceutical up-regulation of the endogenous analgesia 6. system. Medical Hypotheses, 55 (4), 283-288. Grahn, R.E., Will, M.J., Hammack, S.E., Maswood, S., McQueen, M.B., Watkins, L.R. and Maier, S.F. (1999), Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in 7. rats exposed to an uncontrollable stressor. Brain Research, 826 (1), 35-43. Sher, L. (1996), Effects of the weather conditions on mood and behaviour: The role of acupuncture points. Medical Hypotheses, 46 (1), 19-20.