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The major serotonergic systems in the brain arise in the raphe nuclei of the brain stem. Serotonin is synthesized in a group of brain stem nuclei called the raphe nuclei. These neurons project throughout the neuraxis, ranging from the forebrain to the spinal cord. The serotonergic projections are the most massive and diffuse of the monoaminergic systems, with single serotonergic neurons innervating hundreds of target neurons. (Adapted, with permission, from Heimer 1995.) A. A sagittal view of the brain illustrates the raphe nuclei. In the brain these nuclei form a fairly continuous collection of cell groups close to the midline of the brain stem and extending its and length. In thePrinciples drawing here they Science, are shown in Editon more distinct rostral and caudal groups. The rostral raphe nuclei Source: Disorders along of Mood Anxiety, of Neural Fifth project to a large number of forebrain structures. Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available B. This coronal view the brain illustrates some of the May major14, structures at: of http://mhmedical.com/ Accessed: 2017 innervated by serotonergic neurons of the raphe nuclei. Copyright © 2017 McGraw-Hill Education. All rights reserved