Download Immunological Memory And Role Of T Lymphocytes During Viral

Department of Microbiology and Immunology
Seminar for Students…December 2015
Day / Date / Time:
Tuesday
th
15 December 2015
12pm - 1pm
Immunological Memory And Role Of
T Lymphocytes During Viral Infection
Dr. Laura Rivino
Emerging Infectious Diseases
Duke-NUS Medical School
Venue:
National University of
Singapore (NUS),
Department of
Microbiology and
Immunology,
Seminar Room @
5 Science Drive 2,
Blk MD4, Level 2,
Singapore 117545
Convener:
A/Prof Kevin Tan
Abstract
T lymphocytes are part of the adaptive immune response, a sophisticated
defense system present only at higher levels of evolution. The hallmark of
adaptive immune responses is the capacity to “remember” the first
encounter with a pathogen and to respond more rapidly and effectively
following re-infection with the same pathogen. This process named
“immunological memory” is at the basis of vaccination, a practice that has
successfully eradicated deadly viruses such as variola virus (small pox) and
which to date represents the most effective means of controlling human
infectious disease. T cells play a key role in the protective immunity towards
viruses. The anti-viral T cell response that is generated during infection is
shaped by the nature of the virus infection (acute versus chronic infection),
with important implications for disease outcome. In this talk I will illustrate
how T cell responses are generated during viral infection and how memory
T cells are maintained to provide life-long immunity to the virus. The
different methodologies that are currently available for the characterization
of T cell responses will also be described. A better understanding of human
T cell responses during infection is needed for the design of optimal
vaccines.
ALL ARE WELCOME
Selected Publications for Reference
Visit our website @
www.med.nus.edu.sg/mbio
for more upcoming seminars
1. Wherry, E.J., and R. Ahmed. 2004. Memory CD8 T-cell differentiation
during viral infection. J Virol 78:5535-5545.
2. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of
memory T lymphocytes with distinct homing potentials and effector
functions. Nature. 1999 Oct 14;401(6754):708-12.
3. Farber DL, Yudanin NA, Restifo NP. Human memory T cells:
generation, compartmentalization and homeostasis. Nat Rev Immunol.
2014 Jan;14(1):24-35. doi: 10.1038/nri3567.
4. Rivino L. 2015. T cell immunity to dengue virus and implications for
vaccine design. Expert Rev Vaccines. 2015 Nov 27:1-11
5. Rivino L, Kumaran EA, Jovanovic V, Nadua K, Teo EW, Pang SW, Teo
GH, Gan VC, Lye DC, Leo YS, Hanson BJ, Smith KG, Bertoletti A,
Kemeny DM, MacAry PA. Differential targeting of viral components by
CD4+ versus CD8+ T lymphocytes in dengue virus infection. J Virol.
2013 Mar;87(5):2693-706.