Download Life cycle of the Semliki forest virus

Life cycle of the Semliki forest virus
Cell receptors for picornaviruses
Coxakie Polio
Adeno
Rhino
EMCV Coxakie Rhino
Echo
HAV
FMDV,
Echo
Binding of Human rhinovirus to Icam1 receptor
Poliovirus entry into cells
Uncoating strategies of enveloped viruses
*
*Footnote: remember receptors and fusion proteins Completion of viral
life cycle includes
genome replication,
translation of viral
mRNAs, virion
assembly, and exit
as exemplified here
for poliovirus
Most nonenveloped viruses rely on
cell lysis for their exit
Enveloped viruses exit cells by budding
peacefully
Assembly and egress of a herpesvirus Many viruses are capable of direct
cell-to-cell movement
Portals of virus entry
Birth of Venus (fragment)
Alessandro di Mariano Filipepi
(Sandro Boticelli) (1444-1510)
Local and systemic spread of infection
Spread of infection in nerves
Host defense at the cell level
Programmed Cell Death or Apoptosis
At the organismal level,
there is Innate Immune Response activated by
cytokines such as interferon
and
Adaptive
Immune Response
General patterns of infection
Virus is released to infect other hosts
symptoms
Iceberg concept of infection
Cell Response
Lysis of Cell
Cell Transformation
Host Response
Death of Organism
Classic and Severe Disease
Cytopathic Effects
Cell Dysfunction
Viral Replication w/o Cytopathology
or Incomplete Viral Maturation
Exposure w/o
Attachement and/or Entry
Moderate Severity
Mild Illness
Infection w/o Clinical
Illness (Asympto-
matic Infection)
Exposure w/o
Infection