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Laboratory Profile Principal Investigator: Daniel Kaganovich Molecular Mechanism of Neurodegenrative Disease and Protein Aggregation Location: Silberman Wing 3, 5th. floor Room 3-536 Communication: E.Mail: [email protected] Phone: 054-246-2875 Web: www.kaganovichlab.com Brief Description of Research: For a cell to be alive, it must coordinate the function of thousands of proteins and macromolecules over space and time. This coordinated function of proteins relies on efficient management of protein folding throughout the cell. Our lab uses high-resolution 3D time-lapse imaging to study the way in which cells orchestrate the function of a vast and dynamic protein folding quality control system, which includes chaperones that enhance protein folding and regulate protein aggregation. From basic findings in simple cellular models, we develop animal models of neural function and neurodegenerative disease. Our goal is to understand some of the ways in which neurons manage protein folding differently form other cells, and how this contributes to the pathology of diseases such as ALS, Alzheimer’s, Parkinson’s, and Hundington’s Diseases. (for more details, please see website). Techniques used include: high-resolution 3D live-cell confocal imaging; live cell imaging in living organisms; high-throughput image-based genetic screening of yeast genome libraries; super-resolution microscopy imaging in live cells; TIRF microscopy; molecular biology and biochemistry; yeast genetics; mammalian cell culture; computational approaches to understanding protein misfolding and aggregation. Proposed Research Projects: Topic 1: Discovery of novel regulators of protein aggregation using yeast image-based genetics screening and live-cell imaging. Topic 2: Visualizing neural activity in live C. elegans worms and neurodegenerative disease models.