Download 第五屆生物物理新知研討會

第八屆生物物理新知研討會
The 8th Symposium on Recent Advances in Biophysics
P51
Construction and classification of Protein SS bond database
Allen Chuang1, Chun-Yin Chen1 & Jenn-Kang Hwang2*
1
Department of Life Sciences, National Tsing Hua University, HsinChu, Taiwan
2
Department of Biological Science & Technology,Institute of Bioinformatics, National Chiao Tung
University, HsinChu, Taiwan
We found a surprisingly close relationship between disulfide patterns and structures that disulfide patterns can
unambiguously map onto three-dimensional structural folds. In this communication, we classify disulfide
proteins according to their disulfide patterns and found that, in the case of three or more disulfide bonds, each
class comprises of only proteins of similar three-dimensional structures, regardless of their sequence
similarities. Our findings shed new light on the relationship bewteen the protein conformations and their
disulfide patterns, and suggest an alternate way of finding structure homologues in homology modeling. It
would be helpful for structure prediction.