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Download 第五屆生物物理新知研討會
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Transcript
第八屆生物物理新知研討會 The 8th Symposium on Recent Advances in Biophysics P51 Construction and classification of Protein SS bond database Allen Chuang1, Chun-Yin Chen1 & Jenn-Kang Hwang2* 1 Department of Life Sciences, National Tsing Hua University, HsinChu, Taiwan 2 Department of Biological Science & Technology,Institute of Bioinformatics, National Chiao Tung University, HsinChu, Taiwan We found a surprisingly close relationship between disulfide patterns and structures that disulfide patterns can unambiguously map onto three-dimensional structural folds. In this communication, we classify disulfide proteins according to their disulfide patterns and found that, in the case of three or more disulfide bonds, each class comprises of only proteins of similar three-dimensional structures, regardless of their sequence similarities. Our findings shed new light on the relationship bewteen the protein conformations and their disulfide patterns, and suggest an alternate way of finding structure homologues in homology modeling. It would be helpful for structure prediction.
