Download Chapter 1 – Testbank Multiple Choice Questions

Full file at http://testbankcart.eu/Test-Bank-for-Clinical-Laboratory-Blood-Banking-and-TransfusionMedicine-Practices-by-Johns
Chapter 1 – Testbank Multiple-Choice Questions
1. Which scientist proved that infections were caused by microorganisms?
a. Edward Jenner
b. Robert Koch
c. Louis Pasteur
d. Emil von Behring
Answer: b
2. All of the following statements about the innate immune system are true except
a. Acts within minutes or hours of exposure to an infectious organism
b. Includes anatomic and cellular defenses
c. Includes humoral and microbiological defenses
d. Is adaptive
Answer: d
3. The cells of the adaptive immune system arise in the
a. Bone
b. Bone marrow
c. Muscle
d. Pancreatic tissue
Answer: b
4. The term immunogen refers to a substance capable of eliciting the formation of a(n)
a. Antigen
b. Antibody
c. Cytokine
d. Protein
Answer: b
5. Immunoglobulins are roughly _____ -shaped molecules.
a. V
b. W
c. X
d. Y
Answer: d
©2014 by Pearson Education, Inc.
Johns| Gockel-Blessing |Zundel | Denesiuk, Test Bank for Blood Banking
and Transfusion Medicine 1/e
Full file at http://testbankcart.eu/Test-Bank-for-Clinical-Laboratory-Blood-Banking-and-TransfusionMedicine-Practices-by-Johns
6. Which is the principal isotype found in mucosal secretions?
a. IgA
b. IgD
c. IgE
d. IgM
Answer: a
7. Which is the principle isotype found in blood and extracellular fluid?
a. IgD
b. IgE
c. IgG
d. IgM
Answer: c
8. Which of the following statements is true about affinity?
a. Is the sum of all attractive forces between antigens and antibodies
b. Refers to the binding of one or more antigen-binding sites on an antibody to more
than one antigenic determinant on a single carrier
c. Refers to the initial force of attraction between one binding site on an antibody
molecule and a single epitope of the corresponding antigen
d. Results in increased stability of a reaction
Answer: c
9. All of the following statements about agglutination are true except
a. Is defined as the aggregation of particulate matter caused by combination with a
specific antibody
b. Is the visible endpoint of antigen–antibody reactions for blood bank testing
c. Is an irreversible reaction between antigen and antibody
d. Is thought to be a two-step process
Answer: c
10. Most blood group antibodies react optimally at
a. Either cold or hot temperatures
b. Either cold or warm temperatures
c. Cold temperatures only
d. Hot temperatures only
Answer: b
©2014 by Pearson Education, Inc.
Johns| Gockel-Blessing |Zundel | Denesiuk, Test Bank for Blood Banking
and Transfusion Medicine 1/e
Full file at http://testbankcart.eu/Test-Bank-for-Clinical-Laboratory-Blood-Banking-and-TransfusionMedicine-Practices-by-Johns
11. Adequate time is needed for antigen–antibody reactions to reach equilibrium. The amount
of time needed for equilibrium to be reached
a. Is about 30 minutes
b. Is about 60 minutes
c. Is about 90 minutes
d. Varies with each procedure
Answer: d
12. Optimal pH has not been determined for immunohematologic testing, but it is generally
believed that testing should be performed within what pH range?
a. 4.2–5.8
b. 5.8–7.5
c. 6.8–7.2
d. 7.0–8.8
Answer: c
13. All of the following statements are true about the second step of the agglutination process
except
a. Is dependent upon many factors, including the ionic strength of the test system, pH,
and temperature
b. Occurs when antigen and antibody come together to form an immune complex
c. Occurs when antibody cross-links form between red blood cells, creating a lattice
d. Occurs when an antibody is be able to bind to an epitope on each of two different red
blood cells
Answer: b
14. What is the best description of cytokines?
a. Glycoproteins bound to red blood cell membranes
b. Proteins released by cells that affect the behavior of other cells
c. Small proteins that attract and cause the migration of cells
d. Substances that evoke an immune response
Answer: b
15. According to the clonal selection theory, lymphocytes are
a. Activated if an antigen binds to its receptors
b. Activated if an immunglobulin binds to its receptors
©2014 by Pearson Education, Inc.
Johns| Gockel-Blessing |Zundel | Denesiuk, Test Bank for Blood Banking
and Transfusion Medicine 1/e
Full file at http://testbankcart.eu/Test-Bank-for-Clinical-Laboratory-Blood-Banking-and-TransfusionMedicine-Practices-by-Johns
c. Eliminated if they are bound to antibody
d. Eliminated if they react to self antigens
Answer: a
16. When a naive B cell leaves the bone marrow, it has membrane-bound ________
antibody.
a. IgA and IgE
b. IgA and IgM
c. IgD and IgE
d. IgD and IgM
Answer: d
17. Which class of antibodies is generally less efficient at activating complement but may
cause extravascular hemolysis or destruction of the red blood cells outside the
circulation?
a. IgD
b. IgE
c. IgG
d. IgM
Answer: c
18. Approximately how many serum proteins are found in the complement system?
a. 10
b. 20
c. 30
d. 40
Answer: c
19. Which of the following statements is true about the lectin pathway?
a. Involves a recognition unit and an activation phase
b. Is activated in an antibody-independent fashion
c. Is usually triggered by an immunoglobulin–antigen complex
d. Primarily responds to charged and neutral sugars
Answer: b
20. All of the following are true about the classical pathway except
a. Begins with formation of C1 from C1q, C1r, and C1s molecules
©2014 by Pearson Education, Inc.
Johns| Gockel-Blessing |Zundel | Denesiuk, Test Bank for Blood Banking
and Transfusion Medicine 1/e
Full file at http://testbankcart.eu/Test-Bank-for-Clinical-Laboratory-Blood-Banking-and-TransfusionMedicine-Practices-by-Johns
b. Consists of C5b and C6–C9
c. Is regulated by two mechanisms in the fluid phase
d. Is regulated on cell surfaces with complement control proteins
Answer: b
©2014 by Pearson Education, Inc.
Johns| Gockel-Blessing |Zundel | Denesiuk, Test Bank for Blood Banking
and Transfusion Medicine 1/e