Download Bioinformatics (Attwood et al.,)

Bioinformatics :
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Definitions of Bioinformatics
• The study of the information content and information
flow in biological systems and processes (Michael Lieman).
• is the field of science in which biology, computer science,
and information technology merge to form a single
discipline (www.ncbi.nlm.nih.gov)
• Bioinformatics may be broadly defined as the interface
between Life Sciences and Computational Sciences
(www.bic.nus.edu.sg)
• Is an interdicsiplinary research area at the interface
between computer science and biological science (Jin
Xiong, 2006)
• Bioinformatics involves the technology that uses
computers for storage, retrievel, manipulation, and
distribution of information related to biological
macromolecules such as DNA, RNA, and proteins.
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Life Sciences
Bioinformatics
Information Technology
Computer Science
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BIOFORMATICS VS
COMPUTATIONAL BIOLOGY
Bioinformatics is limited to sequence,
structural and functional analysis of genes
and genomes and their corresponding
products
and
is
often
considered
computational molecular biology.
Computational Biology encompasses all
biological areas that involve computation.
For example, mathematical modeling of
ecosystem,
population
dynamics,
applications of the game theory in behaviour
studies.
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GOAL OF BIOINFORMATICS
1. Is to better understand a living cell and how it function
at the molecular level.
2. By analyzing raw molecular sequence and structural
data, bioinformatics research can generate new insight
and provide a global perspective of the cell (The flow
of genetic information is dictated by the central dogma
of biology DNA , RNA and protein
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Bioinformatics -TimeLine
• Single Structure :
–
–
–
Modeling &geometry
Simulation
Docking
• Sequence, sequence-structure relationship:
–
–
–
Aligment
Structre prediction
Fold recognition
1980
1985
1990
• Genomic :
–
–
–
Dealing with many sequence
Gene finding & genome annotation
Databases
• Intregrative Analysis :
–
–
–
Expression & proteomic data
Data mining
Simulation again…. (whole cells)
1995
2000
2005
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Why Do We Need Bioinformatics
• Data flow in biology :
– Human genome project : DNA sequence
– Microarray : RNA expression and levels
– Proteomics : protein expression and
concentration in cells
– Structural proteomic or genomic : protein
structur (and function)
– Functional genomics protein function
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Human Genome Project
Pertumbuhan
database mencapai
2-3 Terabyte DNA
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Study of Bioinformatics
1.
2.
3.
4.
5.
6.
7.
8.
Informations networks
Protein information resources
Genome information resources
DNA sequence analysis
Pairwise alignment techniques
Multiple sequence alignment
Secondary database searching
Building a sequence search protocol
Analysis packages
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Post-Genome Wish List
1. Drug Design
2. Designer Protein and Biomaterials
3. Genetic Engineering and gene
therapy
4. Vaccine design
5. Personalized medicine
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Gene Bank – National Center Biotechnology
Information
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STUDI KASUS FLU BURUNG (VIRUS H5N1)
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URUTAN DNA DARI VIRUS H5N1
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STRUKTUR 3D DARI VIRUS H5N1
(domain neuraminidase)
Struktur 3D untuk
mempelajari &
desain obat (new
drug desain) H5N1
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DATABASE FLU BURUNG (VIRUS H5N1)
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SEARCH FLU BURUNG (VIRUS H5N1) INDONESIA
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HASIL DATABASE FLU BURUNG (VIRUS H5N1)
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STUDI FILOGENETIKA VIRUS H5N1
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Materi ebook dan praktikum dapat di
download di
http://www.sith.itb.ac.id/mgbm/adi.htm
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