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Vectorial discharge of a secretory polypeptide across the ER membrane mediated by a cleavable N-terminal insertion signal. The cotranslational passage
of a polypeptide, such as a secretory or lysosomal protein, into the ER lumen is represented in a simplified form that does not include any molecular
components of the translocation machinery. The translocation is initiated by an N-terminal signal that is cleaved during the course of polypeptide chain
elongation and is completed after polypeptide termination. The signal that has emerged from the ribosome leads to the association of the nascent chain
and the ribosome with the membrane. The signal has been drawn as remaining in the membrane after it is cleaved. Its fate, however, has not yet been
determined.
Source: The Biogenesis of Membranes and Organelles, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular
Bases of Inherited Disease; 2014 Available at: http://mhmedical.com/ Accessed: August 03, 2017
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