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A. M. Pryshlyak, M. S. Hnatyuk, I. O. Stakhurska INFORMATION ANALYSIS OF RESTRUCTURAL HEART VENTRICLES PECULIARITIES INFLUENCED BY CADMIUM CHLORIDE SHEE «I. Ya. Horbachevsky Ternopil State Medical University», Department of Topographic Anatomy and Operative Surgery. Key words: ventricular myocardium, morphometry, toxic injury, adaptation. The environmental pollution with chemicals and their metabolites has negative effect on functions of heart and blood vessels. The problem of cardiotoxicity is complicated and is not enough elaborated. Structural changes of heart muscle in cadmium salts effect on the organism, that have the ability to be caught in the environment because of human activity, are not enough discovered. The object of the work is information analysis of restructural heart ventricles peculiarities influenced by cadmium chloride. Materials and methods. The hearts of 36 white male rats, which were divided into 2 groups (1-st – 12 intact animals, 2-d – 24 rats injected with cadmium chloride) by complex of morphological methods (histology, histochemistry, morphometry) have been examined. Toxic myocardial injury by chemical element has been modeled by subcutaneous injection in a dose of 6 mg/kg during 4 weeks. the diameter of cardiomyocytes and the diameter of their nuclei, the nuclear-cytoplasmic index, the length of cardiomyocytes, the total number of cardiomyocytes, the relative volume of cardiomyocytes, the relative volume of the capillaries, the relative volume of the connective tissue, stromal and kardiomiothytarical interralations, capillary and kardiomiothytarical interralations, relative volume of cardiomyocytes focal damages of left and right ventricles have been identified histostereometricaly. To evaluate cardiomyocites space changes of the affected heart parts and interrelations between them information analysis has been used to define entropy, relative entropy and redundancy. Euthanasia of experimental animals was carried out by bloodletting under the tiopenthaloval anesthesia. The parts of the left and right ventricles of the heart, were cut out and fixed in 10.0% neutral formalin solution. after the appropriate conducting through the increasing concentration of ethyl alcohol the parts were placed into paraffin. Microtome cuts were stained with hematoxylin eosin by van Gisone, Heidenhain, Mallory, Vaihert. Quantitative values were treated statistically. It was discovered by histostereometrical methods that infusion of cadmium chloride resulted in the injury of cardiomyocytes and their hypertrophy. The diameter of left ventricular cardiomyocytes under the influence of cadmium chloride increased on 43.2%, their nuclei - 30.9%, right ventricle - 30.2% and 20.0%. the nuclear and cytoplasmic relations in cardiomyocytes of both ventricles were significantly changed under those conditions. The relative volume of the stroma in the left ventricle in simulated pathological conditions increased in 2.1 times, and the relative amount of capillaries decreased – in 19, 6%, and the right - in 1.6 times and 16.3%. Prolonged exposure of cadmium chloride on white rats organism resulted in the damage of a large number of cardiomyocytes. Thus, the relative amount of damaged cardiomyocytes in the left ventricle in simulated pathological conditions increased in 21.8 times, and in the right ventricle - in 16.3 times. Histologically in the investigated chambers of the heart plethora mainly in veins and remote parts of the microcirculatory channel was observed. Their extension, plethora, stasis, perivasal edema and centres of diapetesical hemorrhages in postcapillaries and venules were observed In that case. There were detected hidropical degeneration, necrobiosis centers and focuses of cellular infiltration of the stroma in the heart muscle cells. Described above structural changes were dominated in the left ventricle. According to the data of information analysis of restructural heart ventricles cardiomyocytes was determined that in conditions of simulated pathology the increase of entropy and relative entropy in left (11.4%, 10.5%) and in right (8.6% at 6.3%) ventricles was observed. The decrease of redundancy in 2.7 times of the left ventricle and in 1.8 times of the right ventricle was observed too. The marked increase of entropy and relative entropy indicate instability and disorganization of the researched structural and functional systems (left and right ventricles). The revealed significant decrease of redundancy in both ventricles of the heart, indicates that the effect of cadmium chloride on the organism of experimental animals not only damages cardiomyocytes, stroma and blood vessels of the left and right ventricles of the heart, but significantly reduces their adaptation reserves. Conclusion. The poisoning of experimental animals with cadmium chloride leads to severe restructuring of left and right ventricles, accompanied by significant changes of carriers of biological information. At the same time entropy, relative entropy have increased in the studied chambers of the heart and redundancy was decreased, which indicated on disorganization, instability and reduced reserves of damaged structures adaptation. Structural changes were dominated in the left ventricle.