Download B. Are the main cells involved in acute inflammation

Final Examination of Medical Immunology (B)
(For 7-year course medical students
2003-10-30)
Choose the single best answer.
1Antibody can bind to
A antigenic determinents
C the whole antigen molecule
B BCR
D TCR
2Factors influence immunogenicity include
A foreignness
B molecular size
C chemical composition
D all above
3 Haptens are the molecules that
A possess antigenicity
C possess immunogenicity
B are large protein
D can induce the production of antibody
4 The first immunoglobulin class produced in a primary response to an antigen is
A IgA
B IgG
C IgM
D IgE
5 The most abundant immunoglobulin class in serum is
A IgA
B IgG
C IgM
D IgE
6 The Ig which serves an important effector function at mucous membrane surface is
A IgA
B IgG
C IgM
D IgE
7 The domains which immunoglobulin bind to epitope are
A constant region
B variable region
C framework region
D hinge region
8 The monomer of IgM is composed of
A two γheavy chains,and two κor two λlight chains.
B two μheavy chains,and two κor two λlight chains.
A two εheavy chains,and two κor two λlight chains.
A two δheavy chains,and two κor two λlight chains.
9 Papain can digest the entire IgG into
A two Fab fragment and one Fc fragment.
A one Fab fragment and one Fc fragment.
A two F(ab’)2 fragment and one Fc fragment.
A one F(ab’) 2 fragment and pFc’.
10 C1q-binding site of IgM is located in
A CH1
B CH2
C CH3
D CH4
11The most efficient Ig involved in the classical pathway of complement activation is
A IgA
B IgG
C IgM
D IgE
12 In the classical pathway of complement activation, C3 convertase is
A C4b2a
B C3bBb
C C4b2a3b
D C3bBb3b
13 The fragment that does not belong to the anaphylatoxin is
A C3a
B C3b
C C4a
C5a
14 The fragment involves in the opsonization is
A C3a
B C3b
C C4a
C5a
15 The regions that encode Class I MHC molecules are
A locus A
B locus B
C locus C
D all above
16 In Class I MHC molecules,peptide-binding site consist of
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A α1 and α2 domains
B α1 and α3 domains
C α1 and β1 domains
17 Biological role of the MHC proteins do not consist of
A A fundamental role in regulating immune responses.
B Ag presentation
C Self-MHC restriction.
D Control of B cell development
18 The component which is capable of lysing microorganisms is
A C1-9
B C5-9
C C3-5
D C8-9
19 In the classical pathway of complement activtion,the active sequence is
A C123456789
B C124536789
C C142356789
D C124356789
20Which property does not belong to cytokines
A Pleiotropy
B Redundancy
C Synergy
D Specificity
21 The formation of C3bBb can be inhibited by
A DAF
B factor I
C factor H
D all above
22 MBL activates the complement system via its ability to
A directly cleave C4
Cdirectly cleave C2
B directly cleave C3
D bind to C1q
1. All of the following are true about neutrophils
D β2m
EXCEPT…
A. Have receptors for complement components and chemoattractive
factors
B. Are the main cells involved in acute inflammation
C. Their granules involved in microbia killing
D. Are cells of the adaptive immune system
2. All of the following are true about macrophages EXCEPT…
A. Settle mainly in the tissue.
B. Can phagocyte microbes and dead body cells.
C. Express CD14
D. Only involve in innate immunity
3.Opsonins include
A. the complement component C3b and antibody
B. MHC moleculars
C. Antigen
D. Cytokines
4.Nature killer cells
A. can kill virus infected cells by specific receptors recognization.
B. Secrete gamma interferon ( IFN ).
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C. Can not be activated by IL-2.
D. Do not express KAR and KIR.
5. All of the following are secondary lymphoid organs except…
A. Spleen.
B. Bone marrow.
C. Lymph nodes.
D. Mucosa associated lymphoid tissue .
6.All of the following are true about thymus
Except…
A. is the organ where T cell precursors mature.
B. Provid positive selection and negative selection for T cells.
C. Absent in new born mouse will cause T cell mediate immunity
disorder.
D. Absent in new born mouse will not affect B cell mediate immunity .
7.T cells do not…
A. express CD3
B. produce cytokines to help other cell types.
C. Mediate their functions by cell to cell contact.
D. Recognize protein antigens without APC cells’ associated.
8.Th2 cells do not…
A. express CD4.
B. Produce IL-4,IL-10 et al.
C. Involve in inflammatory .
D. Help B cells activation.
9.Tc cells do not…
A.
B.
C.
D.
express CD8.
Mediate killing of virus infected cells .
release lytic granules
recognise antigens with MHC class II molecles.
10. All of the following are true about cell mediated immunity
Except…
A. Mediate by activated T cells and macrophages.
B. Can be transferred by T cells.
C. some times can cause delayed-type hypersensitivity.
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D.have no relationship with other cells.
11. T cell receptor (TCR) do not…
A. provide T cell specificty.
B. secrete.
C. only recognize the MHC-antigen peptides complex.
D.usualy express / dimers.
12. All of the following are professional APC
A. Mast cells.
B. Macrophages.
Except…
C. B cells.
D. Dendritic cells.
13. The endogenous pathway of antigen presentation involves…
A. presentation of antigen on MHC class II molecules.
B. presentation of antigen to cytolytic T cells.
C. presentation of antigen to Th2 cells.
D. presentation of antigen to B cells.
14. All of the following are true about hypersensitivity
A. is an unsual immune response.
B. is caused by antigen.
Except…
C. is primary immune response.
D. can be classfide to four types.
15. The procedure that detects the production of antibody blocking the
actions of a microorganism is:
A. Agglutination
B. Enzyme-linked immunosorbent assay
C. Neutralization
D. Single radial immunodiffusion
16. In enzyme-linked immunosorbent assay:
A. Antibody or antigen is bound to an enzyme, which catalyzes a
reaction.
B. Substrates for reaction is converted to a colored end-product.
C. Antigen or antibody can be detected quantitatively with extremely
sensitive.
D. All the above.
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17. All of the following involved in Immediate hypersensitivity except…
A. mast cells
B. IgE
C. histamine
D. platelets
18. Hemolytic disease of the newborn due to RhD incompatibility
depends upon the…
A. transplacental passage of IgG anti-RhD antibodies.
B. transplacental passage of IgM anti-RhD antibodies
C. production of cytoxic antibodies by the baby.
D. The first pregnancy of the mother.
19. All of the following are true about immune-complex mediated
type III hypersensitivity Except…
A. immune-complex can form to serum produces.
B. Tissue damage can be caused by complement activation.
C. Include the arthus reaction.
D. Requires cytotoxic T cells.
20. All of the following are true about delayed-type hypersensitivity
Except…
A. is mediated by T lymphocytes.
B. include contact sensitivity.
C. include the tuberculin reaction.
D. include Farmer’s lung.
21. Live vaccines are dangers to the following people except…
A. a pregnant woman.
B. Tenngers.
C. An immunologically incompetent host.
D. Patients receiving immunosuppressive drugs.
22. which of the following cell types is not involve in antibody
production…
A. Cytotoxic T cells.
B. B cells.
C. Th2 cells.
D. Macrophages.
23. On the B cell surface, receptors for antigen are associated with…
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A. B5 molecules
B. Ig and Ig.
C. MHC class I molecules.
D. MHC class II molecules.
24. All of the following are true about memory humoral immune response
Except…
A. usually produce more IgG class antibody.
B. The lag period is much shorter than the primary immune response.
C. The affinity of antibodies is maturated.
D. Produce IgM antibodies without class switching.
25. stimulation of antigen-specific T cells by appropriately presented
antigen alone results in…
A. anergy.
B. Activation resulting in cell proliferation.
C. Production of varies cytokines.
D. Release of perforin and granzymes.
26. A B cell can express on its cell surface…
A. membrane IgM and IgD at the same time.
B. CD2 molecules.
C. CD3 molecules.
D. IgG that can bind several different unrelated antigens.
27. T lymphocytes can be activated by…
A. specific antigen.
B. Mitogen.
C. Cytokines.
D. All of the above.
28. To identify antigens on live cells can use…
A. ELISA.
B. FACS
C. RIA
D. All of the above.
29. Both immune complex disease and delayed type hypersensitivity
involve…
A. IgG or IgM antibodies.
B. Complement.
C. Phagocytic cells.
D. B cells.
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30. B cell activation can be modulated by the following molecules
except…
A. CD19.
B. CD21.
C. CD32.
D. CD28.
Answer sheet for multiple choice question
1. A B C D
ABCD
ABCD
ABC D
ABCD
ABCD
ABCD
ABCD
ABC D
ABCD
ABCD
ABC D
ABCD
ABCD
ABC D
ABCD
ABCD
ABCD
ABCD
ABCD
ABC D
ABCD
ABC D
ABCD
ABCD
ABCD
ABC D
ABC D
ABCD
ABCD
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