Download Table S1.

Supplementary Table 1.- Abbreviation, full name and function of all genes investigated
Gene
Bmal1
Clock
Per 1
Per 2
Rev-erb 1α
Srebp1
Srebp 2
Lxr
Pparα
Pparγ
D6Fad
D5Fad
Elovl2
Elovl5a
Fas
Hmgcr
Mev
Dhcr7
Ipi
Abca1
Cyp71α
Cpt1
Full Name
Gene Function
Brain and muscle aryl hydrocarbon Forms part of the positive arm the circadian
receptor nuclear translocator (ARNT)-like
molecular clock. BMAL forms hetrodimer with
CLOCK and initiates the transcription of Per and Cry
genes.
Circadian Locomotor Output Cycles Kaput In conjunction with BMAL forms the positive arm of
the circadian clock and regulates negative elements
Cry and Per.
Period1
In conjunction with Cry genes forms negative
components of the circadian clock.
Period2
In conjunction with Cry genes forms negative
components of the circadian clock.
Nuclear receptor subfamily 1, group D, NR1D1 is regulated in a circadian manner by BMAL
member 1
and via E-box elements regulates a number of clock
controlled genes.
Sterol Regulatory Element-Binding Protein Indirectly involved in cholesterol synthesis. In
1
mammals involved in sensing cholesterol availability
in the ER
Sterol Regulatory Element-Binding Protein Indirectly involved in cholesterol synthesis by
2
regulating Hmgcr.
Liver x receptor
Regulates cholesterol and fatty acids by activating
Cyp7a , the rate limiting enzyme in the conversion of
cholesterol to bile acid.
Peroxisome proliferator-activated receptor Role in promoting hepatic fatty acid oxidation and
alpha
ketogenesis in response to fasting.
Peroxisome proliferator-activated receptor Activates transcriptional programs for lipid storage
gamma
and lipogenesis.
D6 – Fatty acid desaturase
Required for the synthesis of highly unsaturated fatty
acids.
D5 – Fatty acid desaturase
Required for the synthesis of highly unsaturated fatty
acids.
Elongation of very long chain fatty acids Participates in the biosynthesis of long chain poly
protein 2
unsaturated fatty acids. Elongation of C22.
Elongation of very long chain fatty acids Participates in the biosynthesis of long chain poly
protein 5
unsaturated fatty acids. Primarily the elongation of
C18 and C20.
Fatty acid synthase
Corresponding protein catalyzes fatty acid synthesis
3-hydroxy-3-methyl-glutaryl-CoA
Resulting HMGCoA reductase enzyme is the rate
reductase
limiting enzyme in cholesterol synthesis.
Mevalonate kinase
Catabolizes mevalonate to mevalonate-5P
D-7 dehydrocholesterol reductase
Catalyzes the conversion of 7-dehydrocholesterol to
cholesterol.
Isopentenyl diphosphate isomerase
Isomerase that catalyzes the conversion of the
relatively un-reactive isopentenyl pyrophosphate to
the more reactive electrophile dimethylallyl
pyrophosphate
ATP-binding cassette, subfamily A, member Key gatekeeper influencing intracellular cholesterol
1
transport
Cholesterol 7a-hydroxylase 1 alpha
Rate limiting enzyme in bile acid synthesis
Carnitine palmitoyltransferase I
Mitochondrial enzyme that mediates the transport of
long-chain fatty acids across the membrane by
binding them with carnitine
Aco
ApoA1
Acyl-CoA oxidase
Apolipoprotein A1
ApoB
ApoCII
Apolipoprotein B
Apolipoprotein CII
Ldlr
Low-density lipoprotein receptor
El
Lpla
Lplb
Lplc
Endothelial lipase
Lipoprotein lipase a
Lipoprotein lipase b
Lipoprotein lipase c
Oxidoreductase that participates in β-oxidation
Major apolipoprotein of high-density lipoproteins that
mediates cholesterol removal through the action of
Abca1
Primary apolipoprotein of chylomicrons and LDL
Component of very low density lipoproteins and
chylomicrons
Its activation leads to an increase in cellular
cholesterol uptake
Enzyme that catabolizes HDL-cholesterol
Hydrolizes triglicerides in lipoproteins such as those
found in chylomicrons and very low-density
lipoproteins