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Course Syllabus/Spring 2013 120:360 Biochemistry INSTRUCTORS: OFFICE/OFFICE HOURS: COURSE LOCATION(S): Gerald Frenkel EMAIL: [email protected] 321 Boyden/ by appointment COURSE WEBSITE: Blackboard MEETING TIME(S):MTH 8:30-9:50 Boyden 100 COURSE DESCRIPTION: The objective of this course is to gain a deeper understanding of cell function through the study of the structure, function, and metabolism of its component molecules. PREREQUISITES: Foundations of Molecular and Cellular Biology, Organic chemistry I & II REQUIRED TEXT: Voet, Voet & Pratt, Fundamentals of Biochemistry (Wiley) LEARNING OBJECTIVES/GOALS: Upon successful completion of this course, participants will have a deeper understanding of cell function by having gained knowledge and insight into 1. the structures of its component molecules such as proteins, carbohydrates and lipids 2. the various functions of these molecules as enzymes, in membranes and in lipoproteins. 3. the metabolism of these molecules 4. the energy production and utilization mechanisms of the cell Page 1 Course Syllabus/Spring, 2013 120:360 Biochemistry SCHEDULE AND COURSE OUTLINE: Class number Topic Date Readings in Voet 3rd Edition Preparatory reading 11-19; Ch. 2 Chemistry topics suggested for review (see sheet) 1 1/24 Amino acids Ch. 4 2 1/28 Proteins I 91-93;101-103 3 1/31 Proteins II 125-140 4 2/4 Proteins III 146-150; 156-160; 168172;177-180 5 2/7 Proteins IV 181-197 6 2/11 Lipids 246-254;260-263 7 2/14 Lipoproteins 678-685 2/18 Lecture Exam 1 8 2/21 Carbohydrates 220-231 9 2/25 Enzymes I 322-327; 364-375 Page 2 10 2/28 Enzymes II 375-383 11 3/4 Enzymes III 386-390; 328-330 12 3/7 Enzymes IV 347-357 13 3/11 14 3/14 Glycolysis & fermentation I 486-504; 510-514 15 3/25 Glycolysis & fermentation II 504-510 3/28 Lecture Exam 2 16 4/4 Pyruvate dehydrogenase 570-576; 585 17 4/8 Citric acid cycle 567-570; 576-584 18 4/11 Fatty acid catabolism 685-690; 698-700 19 4/15 Amino acid catabolism 738-747 20 4/18 Oxidation/reduction reactions Electron transport 469-474; 600-618 21 4/22 Electron transport, oxidative phosphorylation 22 4/25 Carbohydrate biosynthesis 552-559 Glycogen 532-536; 540-542; 545 – 552 23 Introduction to metabolism & bioenergetics 4/29 Fatty acid biosynthesis 24 5/2 Lecture Exam 3 5/6 Nucleotide biosynthesis DATE OF FINAL EXAM: 5/15/13 Page 3 451-470 618-631 701-707; 520-521 40-42; 818-838 GRADING POLICY: Your grade for this course will be determined based on the categories listed in the table below. 2 highest lecture exams Final exam TOTAL 35 points each 30 points 100 ATTENDANCE, MAKE-UP, AND LATENESS POLICY: A make-up examination will be available for students who must miss a regularly scheduled exam for an officially approved reason such as a religious holiday, illness or family emergency (see university guidelines). If you would like to request a makeup for any exam, please notify me as soon as possible so that there is sufficient time for me to approve the request. Do not assume you will be able to receive a makeup exam unless it is confirmed by me. Please note: There will be no makeup exams, special assignments etc. to improve your grade. Academic Dishonesty: The course has a zero tolerance policy for academic dishonesty, including plagiarism and cheating. Instances of dishonesty will be punished by a zero on the assignment and consultation with the Academic Integrity Officers to determine if further action is required. If you have any questions about what constitutes plagiarism or cheating, please ask your instructors or refer to the academic integrity websites for Rutgers and NJIT: http://academicintegrity.rutgers.edu/academic-integrity-at-rutgers http://studentconduct.rutgers.edu/ http://www.njit.edu/academics/integrity.php Page 4