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BCAA 4:1:1
4:1:1 BCAA supplement with ESTERDRIVE in tablet form that
rapidly dissolves and is absorbed at gastrointestinal level.
Recommended for: In cases of dietary shortcomings or when physical activity is intense and
prolonged, Pro Muscle BCAA 4:1:1 can contribute to providing the bricks for building the muscles
and preventing muscle proteolysis for energy-generating purposes.
Packaging: jar of 250 tablets.
Typical nutrition information
The BCAA (branched-chain amino acids) comprise: Leucine, Valine, Isoleucine
Mean content
In 5 tabs % NRV*
When we speak about BCAA in a ratio of 2:1:1 or 4:1:1, we mean that the amount of leucine
L-Leucine
3,33 g
contained in the product is greater than the amount of the other two branched-chain amino acids.
L-Isoleucine
0,83 g
Leucine is the amino acid involved in protein synthesis and consequently in recovery, both for
L-Valine
0,83 g
Acetylcarnitine
125 mg
sports practitioners and in the event of dietary shortages. Leucine is important for the construction
Vitamin B6
1,4 mg
100
and maintenance of muscle tissue. It promotes protein synthesis in the muscles and liver; it slows
muscle protein decomposition and promotes regeneration processes. Valine and isoleucine, on
*NRV: Nutrient Reference Value
the other hand, have a strictly energy-generating function. The most common BCAA supplements
are in a ratio of 2:1:1, but numerous studies have shown that sports practitioners experienced the above-mentioned effects more strongly when the
dose of leucine was slightly higher, prompting a greater protein synthesis, less muscle catabolism and a better recovery. Leucine is an amino acid that
is mainly effective in the post-workout phase, unlike valine and isoleucine (with their energy-generating role), and this helps to explain the reasons
behind their presence in different ratios.
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BCAA 4:1:1 is an innovative product because the special ESTERDRIVE formula ensures that rapidly dissolves and is absorbed at gastrointestinal level.
BCAA are metabolized in the mitochondria; valine is converted into a molecule of succinyl-CoA, a Krebs cycle intermediate; isoleucine generates one
molecule of succinyl-CoA and one of acetyl-CoA; and the complete catabolism of leucine produces three molecules of acetyl-CoA, and this process
continues in the Krebs cycle until oxidation is complete. The principal point where BCAA catabolism is regulated is on a level with the branched-chain
ketoacid dehydrogenase (BCKDH) poly-enzyme complex. This mechanism enables BCAA catabolism to be activated, providing the diet is rich in these
amino acids. BCKDH is also activated by low levels of ATP and pH, by glycogen depletion, and by physical exercise. It is worth noting that, in addition
to promoting protein catabolism, sports training also causes an increase in the density and dimension of the mitochondria in the muscle fiber cells - an
adaptation mechanism that already per se gives rise to a greater capacity to oxidize the branched-chain amino acids.
A plentiful supply of amino acids generally seems to activate protein synthesis, while a shortage of essential amino acids has a limiting effect. An
abundance of BCAA (and leucine in particular) in the muscle fibers has a further, powerful anabolic effect. To see how BCAA take effect in regulating
the processes of protein synthesis and degradation, we need to be aware that insulin, IGF-1 and GH influence these same processes too.
The effect may be due to the vasodilation induced by the production of nitric oxide, stimulated by the guanylyl cyclase on the capillary endothelium - an
important component in the mechanisms by means of which GH, IGF-1, insulin and amino acids promote an increase in muscle proteins (anabolism).
Concerning insulin, it seems that its contribution at the time of the ingestion of branched-chain amino acids induces a further positive effect on protein
anabolism, because it appears to change the muscle’s metabolic status from catabolic to anabolic. It has been suggested that this effect is mediated
by the amino acids’ entry inside the cells being facilitated.
Leucine is much more powerful than isoleucine, which in turn is more effective than valine, in directly stimulating protein synthesis and inhibiting cell
proteolysis (catabolism). The physiological mechanism by means of which leucine regulates protein synthesis in the body is an important issue. The
changes in muscle tissue induced by physical exercise are supported by the expression of various genes. The expression of these genes is regulated
on various levels, ranging from DNA transcription to transduction. The signal triggered by leucine seems to increase the availability of a factor
indispensable to the initiation of transduction.
More light has recently been shed on how the degradation of muscle proteins is controlled. It seems that glucocorticoids, and a shortage of amino acids
(including the BCAA, and leucine in particular) stimulate muscle proteolysis, whereas IGF-1 and insulin inhibit it.
Use: 5 tablets a day to be swallowed with water or another fluid at mealtimes. Alternatively, during periods of particularly intensive training, swallow
5 tablets after the workout. Do not chew the product.
Ingredients: L-leucine, L-isoleucine, L-valine, Bulking agent: microcrystalline cellulose, acetylcarnitine, Anticaking agents: magnesium stearate,
silicon dioxide; vitamin B6 (pyridoxine hydrochloride).
Precautions: Do not exceed the recommended dose. Seek a doctor’s advice in the event of prolonged use. The product is contraindicated in cases of
renal or liver disease, pregnancy and in children under 12 years of age. Keep out of reach of children under three years old. Supplements should not
serve as a substitute for a varied diet and balanced diet. It is important to adopt a varied and balanced diet, and a healthy lifestyle.
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